Giant retroperitoneal liposarcoma: A case report and literature review

Herzberg, Jonas; Niehaus, Klaus; Holl‐Ulrich, Konstanze; Honarpisheh, Human; Guraya, Salman Yousuf; Strate, Tim

doi:10.1016/j.jtumed.2019.08.005

Cited by 19 publications

(22 citation statements)

References 32 publications

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“…Upon suspicion, patients subsequently undergo CT scans of the abdomen and pelvis to determine the extent of tumour invasion. MDT consultations play a pivotal role in the management of liposarcomas [8]. Surgical excision remains the most effective treatment modality for retroperitoneal sarcomas, with diffuse involvement of the adjacent organs in the abdominal cavity necessitating en bloc resection of the tumour [8].…”

Section: Discussionmentioning

confidence: 99%

“…MDT consultations play a pivotal role in the management of liposarcomas [8]. Surgical excision remains the most effective treatment modality for retroperitoneal sarcomas, with diffuse involvement of the adjacent organs in the abdominal cavity necessitating en bloc resection of the tumour [8]. En bloc resection is therefore preferred and imperative in cases where large proportions of the tumours encase the abdominal cavity, infiltrating multiple organs.…”

Section: Discussionmentioning

confidence: 99%

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En Bloc Resection of a Giant Retroperitoneal Liposarcoma: A Surgical Challenge

Almas¹,

Ullah²,

Ehtesham³

et al. 2020

Cureus

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Liposarcomas are exceedingly rare entities that evoke malignant transformation of connective tissue and fat cells. These tumours occur throughout the soft tissues of the body, afflicting a myriad of regions. In the adult population, liposarcomas represent the most prevalent subtype of sarcomas, and often arise de novo. Retroperitoneal liposarcomas (RLS) are a ubiquitous subset of sarcomas that, due to their deep location in the hollow abdomen, can grow to astronomical proportions before manifesting any noticeable symptoms; a prompt diagnosis of RLS is therefore often rendered dilatory. We hereby delineate the case of a 43-year-old woman who presented with vague left hemiabdominal distention and discomfort. A subsequent computed tomography scan divulged a giant retroperitoneal growth impaling on and thus displacing the pancreas. A compartmental, en bloc resection was performed, with subsequent histopathology of the excised specimen revealing a well-differentiated liposarcoma. The surgical intervention was curative and led to an uneventful recovery. This paper highlights the pertinence of surgical management as an appropriate treatment modality for a complete resection of RLS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

En Bloc Resection of a Giant Retroperitoneal Liposarcoma: A Surgical Challenge

Almas¹,

Ullah²,

Ehtesham³

et al. 2020

Cureus

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“…13 When the gastrointestinal tract is compressed, patients may feel fullness, anorexia, nausea, vomiting, diarrhea, abdominal pain, bloating, and pain related to constipation or defecation pain. 13,14 In addition, pressure on the kidney may cause hydronephrosis, and pressure on the bladder may cause frequent urination and urgency. 15 Pressure into the chest from a large tumor may lead to breathing difficulties.…”

Section: Discussionmentioning

confidence: 99%

“…12 When diagnosed, PRPLS is often in the late stage, and the corresponding symptoms appear only when the adjacent organs are compressed or when tumors gradually increase in size. 13 When the gastrointestinal tract is compressed, patients may feel fullness, anorexia, nausea, vomiting, diarrhea, abdominal pain, bloating, and pain related to constipation or defecation pain. 13,14 In addition, pressure on the kidney may cause hydronephrosis, and pressure on the bladder may cause frequent urination and urgency.…”

Section: Discussionmentioning

confidence: 99%

Primary retroperitoneal liposarcoma: a rare case report

et al. 2021

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Primary retroperitoneal liposarcoma (PRPLS) is a rare malignant tumor with a low incidence. A 34-year-old female patient presented to our department with abdominal pain, nausea, and vomiting for 2 days. Abdominal computed tomography (CT) indicated a huge mass between the liver and kidney, with a clear boundary and measuring approximately 202 mm × 155 mm ×106 mm. The mass was considered a retroperitoneal lipoma or liposarcoma. The entire tumor was completely resected without auxiliary injury, and histopathology of the resected specimen indicated liposarcoma. The patient recovered well and was discharged from our department on the 6th postoperative day. No signs of relapse were seen during 1-year of follow-up. PRPLS is rare and without obvious symptoms in the early stage. CT plays a vital role in the diagnosis of PRPLS, and surgical resection is considered the most suitable treatment. Radiotherapy and chemotherapy might also be treatment options to improve the overall survival of PRPLS patients.

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“…Combining the excellent results of CT scan characterization of the tumors with these errors of the biopsies we can understand why some authors say that biopsy prior to surgical excision is not entirely necessary [ 17 , 18 , 19 ]. But what can you do when the patient denies biopsy?…”

Section: ⧉ Discussionmentioning

confidence: 99%

T4 retroperitoneal liposarcoma. Challenges of big size sarcomas surgical treatment

Nistor-Ciurba

Lisencu

Tat³

et al. 2021

Rom J Morphol Embryol

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Our article presents some of the challenges of the surgical treatment of T4 (>15 cm) retroperitoneal liposarcomas (up to 65/56/30 cm, 25.5 kg) series of cases treated by the Department of Surgical Oncology, Prof. Dr. Ion Chiricuţă Oncology Institute, Cluj-Napoca (IOCN), Romania, with illustrations, insisting on important blood vessels and nerves dissection and preservation and discussions of strategies with references to important articles from the last 10 years specialty literature. Challenges do not come only from intraoperative difficulties but also from establishing the right attitude from the extent of resection and oncological safety point of view, the role of the pathologist being very important because histological subtype and completeness of the resections are the most important prognostic factors for such tumors. Despite all today available aids in decision making, like nomograms or high-resolution imagery, sometimes this decision is to be taken intraoperative based on surgeon's expertise and skills. That is why is strongly advised that such cases to be treated in high-volume specialized tertiary centers of surgical oncology.

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Giant retroperitoneal liposarcoma: A case report and literature review

Cited by 19 publications

References 32 publications

En Bloc Resection of a Giant Retroperitoneal Liposarcoma: A Surgical Challenge

En Bloc Resection of a Giant Retroperitoneal Liposarcoma: A Surgical Challenge

Primary retroperitoneal liposarcoma: a rare case report

T4 retroperitoneal liposarcoma. Challenges of big size sarcomas surgical treatment

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