Giant skull vault defect in a child caused by Langerhans cell histiocytosis: the “calvaria-eating disease”

Foreign Body Reaction Following Use of a Novel Bone Graft Substitute in Pediatric Cranioplasty

“…The etiology of this adverse outcome was likely multifactorial. Past research has suggested that the use of any foreign material in patients with LCH may stimulate cellular proliferation, as histiocytes are already predisposed to activation 10 . Moreover, despite its generally good biocompatibility, it is possible that the specific formulation of certain calcium phosphate cements can generate immune responses in particular individuals.…”