Gigantic undifferentiated pleomorphic sarcoma (UPS) of breast in a woman: A rare case report

Talebiazar, Nasim; Ahmadi, Ramiar; Anari, Sina; Goli, Rasoul; Nikpey, Shayan; Zareh, Vahideh

doi:10.1016/j.ijscr.2023.108605

Cited by 1 publication

(1 citation statement)

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“…UPS is defined by the lack of identifiable line of differentiation despite exhaustive histological and molecular testing, constituting less than 5% of all sarcomas in adults. The incidence of UPS in the breast is extremely rare and not well documented, but several cases have been reported as either primary or secondary to radiotherapy [ 16 17 18 19 20 ]. Herein, we describe a case of UPS associated with silicone breast implants, which would bring the total number of BIA-mesenchymal tumors to 42 and the total number of BIA-sarcomas in the literature to 9.…”

Section: Introductionmentioning

confidence: 99%

Undifferentiated Pleomorphic Sarcoma Mimicking Breast Implant-Associated Anaplastic Large Cell Lymphoma

Chandrasiri,

Taiwo,

Ahmed

et al. 2024

J Breast Cancer

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Breast implant augmentation is a low-risk procedure with few life-threatening complications, most commonly rupture or leakage and contraction of the capsule. Breast implant-associated (BIA) malignancies are rare. Anaplastic large cell lymphoma (ALCL) is the most well-known neoplastic condition associated with breast augmentation. Carcinomas arising in association with implants have been reported but are rarer than ALCL. BIA-mesenchymal tumors are extremely rare and most are locally aggressive fibromatosis. To date, only eight cases of BIA sarcomas have been reported. Herein, we describe a case of silicone BIA-undifferentiated pleomorphic sarcoma (UPS) that was initially mistaken for ALCL because of a significant clinical and radiological overlap in presentation and imaging. Here, we present the morphological and molecular features of this rare neoplasm. We reviewed the existing literature related to BIA sarcomas to highlight the importance of considering this diagnosis in cases of recurrent ALCL-negative BIA effusions.

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