Gilman reagent toward the synthesis of natural products

Abstract

Gilman reagent (R2CuLi) is a well-established reagent, having exceptional synthetic profile for the total synthesis of both abundant and scarce medicinally significant natural products.

Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

“…Epoxides are three-membered heterocyclic compounds and experience epoxide ring opening reactions due to ring strain. Therefore, these are the substantial intermediates used in natural products synthesis 110 such as synthesis of (+)-discodermolide subunits. (+)-Discodermolide is a natural marine polyketide 107 and a very efficient anticancer agent.…”