Ginger Is a Potential Therapeutic for Chronic Toxoplasmosis

El-Kady, Asmaa M; Al-Megrin, Wafa Abdullah I.; Abdel-Rahman, Iman A. M.; Sayed, Eman M; AlShehri, Eman; Wakid, Majed H.; Baakdah, Fadi; Mohamed, Khalil; Elshazly, Hayam; Alobaid, Hussah M.; Qahl, Safa H.; Elshabrawy, Hatem A.; Younis, Salwa S

doi:10.3390/pathogens11070798

Cited by 6 publications

(4 citation statements)

References 74 publications

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“…However, PYR+SDZ combination-treated mice showed strong P53 expression, and El Sharazly et al have denied the correlation between PYR+SDZ efficacy and its induced apoptosis as the mean number of TUNEL-positive cells in brain sections was low [ 52 ]. ZnO- and Mg-doped ZnO NP-treated mice showed mild P53 expression that indicated the protective effects of ZnO and Mg-doped ZnO NPs against apoptosis in the cerebral tissue [ 62 ]. The anti-apoptotic action of ZnO NPs has been mentioned in earlier research that linked its protective and anti-apoptotic effect to its antioxidant activity that minimizes the stress on living cells [ 27 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Sarhan,

Felemban,

Alelwani

et al. 2024

Pharmaceuticals

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Toxoplasma gondii causes a global parasitic disease. Therapeutic options for eradicating toxoplasmosis are limited. In this study, ZnO and Mg-doped ZnO NPs were prepared, and their structural and morphological chrematistics were investigated. The XRD pattern revealed that Mg-doped ZnO NPs have weak crystallinity and a small crystallite size. FTIR and XPS analyses confirmed the integration of Mg ions into the ZnO framework, producing the high-purity Mg-doped ZnO nanocomposite. TEM micrographs determined the particle size of un-doped ZnO in the range of 29 nm, reduced to 23 nm with Mg2+ replacements. ZnO and Mg-doped ZnO NPs significantly decreased the number of brain cysts (p < 0.05) by 29.30% and 35.08%, respectively, compared to the infected untreated group. The administration of ZnO and Mg-doped ZnO NPs revealed a marked histopathological improvement in the brain, liver, and spleen. Furthermore, ZnO and Mg-doped ZnO NPs reduced P53 expression in the cerebral tissue while inducing CD31 expression, which indicated a protective effect against the infection-induced apoptosis and the restoration of balance between free radicals and antioxidant defense activity. In conclusion, the study proved these nanoparticles have antiparasitic, antiapoptotic, and angiogenetic effects. Being nontoxic compounds, these nanoparticles could be promising adjuvants in treating chronic toxoplasmosis.

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Section: Discussionmentioning

confidence: 99%

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Sarhan,

Felemban,

Alelwani

et al. 2024

Pharmaceuticals

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“…T. gondii is a protozoan parasite that infects warm-blooded animals, including cats and humans ( EI-Kady et al, 2022 ). In immunocompetent individuals, T. gondii infection is often asymptomatic or an influenza-like illness ( Zhou et al, 2011 ), but it can be life-threatening in immunocompromised patients ( e.g ., patients with cancer or those who have undergone solid-organ transplantation) ( Dard et al, 2018 ; Pinto et al, 2020 ; Thirugnanam, Rout & Gnanasekar, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii infection in women with a gynecological tumor living in eastern China

Wang

et al. 2022

PeerJ

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The association between Toxoplasma gondii (T. gondii) infection and malignancy has attracted increased attention in recent years, but little is known of T. gondii infection among women diagnosed with a gynecological tumor (GT) in China. We conducted a case-control study involving 460 women diagnosed with a GT and 460 age-matched healthy controls (HCs) to estimate the infection process of T. gondii and understand the risk factors of T. gondii infection in patients with a GT. Levels of anti-T. gondii IgG and IgM were measured by enzyme-linked immunoassays every 12 months. After a median follow-up time of 4.3 years (range 4 to 5 years), 55/460 (11.96%) patients with a GT and 15/460 (3.26%) HCs were seroprevalence for T. gondii antibodies, respectively (P = 0.001). IgG antibodies against T. gondii were found in 54 GT patients (11.74%) and 15 HCs (3.26%), respectively (P = 0.001). The seroprevalence of T. gondii IgM antibodies was similar in patients with a GT and with HCs (2.83% vs 1.3%, P = 0.105). Multivariate stepwise logistic regression analysis revealed contact with cats (OR, 6.67; 95% CI [2.89–10.75]; P = 0.001), exposure to soil (OR, 2.16; 95% CI [1.14–4.10]; P = 0.019), being a farm-worker (OR, 4.17; 95% CI [1.20–11.49]; P = 0.006) and history of chemotherapy (OR, 3.16; 95% CI [1.56–6.45]; P = 0.001) to be independent risk factors for T. gondii infection. Women with an ovarian cancer or endometrial cancer had higher T. gondii seroprevalence than that of HCs. Moreover, T. gondii infection in patients with a GT mostly acquired within two years of diagnosis, but the infection in healthy controls had no obvious time characteristics. Here, we demonstrated that T. gondii infection is significantly higher in patients with a GT (especially in women with an ovarian tumor) compared to HCs. Thus, infection with this parasite should be avoided in patients with a GT, and the causal relationship between T. gondii and GTs should be studied in detail.

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“…It is widely used in medicinal purposes and dietary condiments due to its therapeutic and nutrition value. 16 Most traditional and complementary systems of medicine, such as Ayurveda, recommend ginger to manage various disease conditions as a result of their anti-inflammatory and antinausea properties. 17 , 18 In recent times, the rhizome, or root, of ginger has been widely studied for exhibiting antimicrobial, antitumor, antidiabetic, and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

“…Nonvolatile pungent compounds include gingerols, shogaols, paradols, and zingerone. 16,20 Ginger extract (GE) has been known to exhibit anti-inflammatory activity by suppressing the biosynthesis of inflammatory mediators, 5-lipoxygenase and cyclooxygenase inhibition, and inhibition of nitric oxide production. These therapeutic activities may be attributed to the presence of different bioactive materials.…”

Section: Introductionmentioning

confidence: 99%

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model

Hassan¹,

Hofni²,

Abourehab³

et al. 2023

IJN

Self Cite

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Introduction Ginger extract (GE) has sparked great interest due to its numerous biological benefits. However, it suffers from limited skin permeability, which challenges its transdermal application. The target of the current work was to develop transethosomes as a potential nanovehicle to achieve enhanced transdermal delivery of GE through the skin. Methods GE–loaded transethosomes were prepared by cold injection using different edge activators. The fabricated nanovesicles were evaluated for particle size, ζ-potential, encapsulation efficiency, and in vitro drug release. The selected formulation was then laden into the hydrogel system and evaluated for ex vivo permeability and in vivo anti-inflammatory activity in a carrageenan-induced rat-paw edema model. Results The selected formulation comprised of sodium deoxycholate exhibited particle size of 188.3±7.66 nm, ζ-potential of −38.6±0.08 mV, and encapsulation efficiency of 91.0%±0.24%. The developed transethosomal hydrogel containing hydroxypropyl methylcellulose was homogeneous, pseudoplastic, and demonstrated sustained drug release. Furthermore, it exhibited improved flux (12.61±0.45 μg.cm 2 /second), apparent skin permeability (2.43±0.008×10 −6 cm/second), and skin deposition compared to free GE hydrogel. In vivo testing and histopathological examination revealed that the GE transethosomal hydrogel exhibited significant inhibition of edema swelling compared to free GE hydrogel and ketoprofen gel. The animals that were treated with ginger transethosome hydrogel showed a significant decrement in reactive oxygen species and prostaglandin E 2 compared to untreated animals. Conclusion Transethosomes might be a promising new vehicle for GE for effective skin permeation and anti-inflammation. To the best of our knowledge, this work is the first utilization of transethosomes laden into hydrogel as a novel transdermal delivery system of GE.

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Ginger Is a Potential Therapeutic for Chronic Toxoplasmosis

Cited by 6 publications

References 74 publications

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Zinc Oxide and Magnesium-Doped Zinc Oxide Nanoparticles Ameliorate Murine Chronic Toxoplasmosis

Seroprevalence of Toxoplasma gondii infection in women with a gynecological tumor living in eastern China

Ginger Extract–Loaded Transethosomes for Effective Transdermal Permeation and Anti-Inflammation in Rat Model

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