Gingival crevicular fluid interleukin‐8 and lipoxin A<sub>4</sub> levels of smokers and nonsmokers with different periodontal status: a cross‐sectional study

Lütfioğlu, Müge; Aydoğdu, Ahmet; Sakallıoğlu, Elif Eser; Alaçam, Hasan; Pamuk, Ferda

doi:10.1111/jre.12324

Cited by 21 publications

(31 citation statements)

References 61 publications

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“…Consistent with the findings of earlier studies regarding LXA4 using GCF samples (Lütfioğlu, Aydoğdu, Sakallioğlu, Alaçam, & Pamuk, ; Tarannum & Faizuddin, ), the data presented herein confirm that the decrease in salivary levels of LXA4 can be an indicator of susceptibility to periodontitis. Although the precise underlying mechanisms for this observation are not fully elucidated, there is substantial evidence that LXA4 is a pro‐resolving and anti‐inflammatory mediator (Serhan et al, ; Spite & Serhan, ; Tarannum & Faizuddin, ) that acts inducing neutrophil apoptosis (Van Dyke & Serhan, ) as well as reducing polymorphonuclear neutrophils (PMN) transmigration, adhesion receptor expression, pro‐inflammatory cytokine generation, excessive PMN infiltration into inflamed tissues and natural killer cell cytotoxicity (Spite & Serhan, ).…”

Section: Discussionsupporting

confidence: 92%

“…Some researchers have established that both physiologic conditions such as ageing (Arnardottir, Dalli, Colas, Shinohara, & Serhan, ) and environmental stressors such as smoking habit (Lütfioğlu et al, ; Van der Does et al, ), might lead to important changes in the levels of SPMs which could have a significant effect on data interpretation. Based on the current data analyses, not only the gender, but also smoking habit, and the age of the study participants met the criteria to be considered confounders for the association between salivary levels of SPMs and disease status ( p < 0.20).…”

Section: Discussionmentioning

confidence: 99%

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Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Tobón‐Arroyave

Isaza-Guzmán

Gómez-Ortega

et al. 2019

J Clinic Periodontology

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Aim This cross‐sectional case–control study aimed to determine if salivary levels of lipoxin A4 (LXA4), protectin D1 (PD1), resolvin E1 (RvE1) and maresin 1 (MaR1) might constitute a reflection of periodontal health/disease status. Materials and methods One hundred and two periodontitis patients and 61 healthy controls were recruited. Periodontal clinical status was determined by criteria based on full‐mouth clinico‐radiographical data. Salivary concentration of the analytes was calculated by enzyme‐linked immunosorbent assay. The association between the biomarkers with disease status was assessed individually and adjusted for confounding using multivariate binary logistic regression models. Results Significantly decreased LXA4 and increased PD1/MaR1 salivary levels were detected in periodontitis patients in comparison with healthy controls. However, no significant differences were observed for RvE1 levels between clinical groups. Clinical parameters such as probing depth, clinical attachment loss and extent were negatively correlated with LXA4, positively correlated with PD1/MaR1 and not correlated with RvE1 salivary levels. Logistic regression analyses revealed a strong/independent association of LXA4, PD1 and MaR1 salivary levels regarding disease status. Interaction effects between demographic predictor variables and salivary concentration of LXA4, PD1 and MaR1 were also identified. Conclusion The results of this study demonstrated a strong/independent association between reduced LXA4 and increased PD1/MaR1 salivary levels with periodontitis suggesting an imbalance in the specialized pro‐resolving lipid mediators (SPMs) in periodontal disease.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Tobón‐Arroyave

Isaza-Guzmán

Gómez-Ortega

et al. 2019

J Clinic Periodontology

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“…, Lutfioglu et al. ) supporting differences in colonization and local and systemic reactivity of smokers compared to non‐smokers. As importantly, the subset of periodontitis patients that were determined to present distinct profiles, including non‐standard and unlinked responses, will be of particular interest relative to the details of their disease and treatment response experiences.…”

Section: Discussionmentioning

confidence: 91%

Integrated biomarker profiling of smokers with periodontitis

Nagarajan

Al‐Sabbagh

Dawson

et al. 2017

J Clinic Periodontology

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In the context of precision medicine, understanding patient-specific variation is an important step in developing targeted and patient-tailored treatment regimens for periodontitis. While several studies have successfully demonstrated the usefulness of molecular expression profiling in conjunction with single classifier systems in discerning distinct disease groups, the majority of these studies do not provide sufficient insights into potential variations within the disease groups. Aim The goal of the present study is to discern biological response profiles of periodontitis and non-periodontitis smoking subjects using an informed panel of biomarkers across multiple scales (salivary, oral microbiome, pathogens and other markers). Materials and Methods The investigation uses a novel ensemble classification approach (SVA-SVM) to differentiate disease groups and patient-specific biological variation of systemic inflammatory mediators and IgG antibody to oral commensal and pathogenic bacteria within the groups. Results Sensitivity of SVA-SVM is shown to be considerably higher than several traditional independent classifier systems. Patient-specific networks generated from SVA-SVM are also shown to reveal cross-talk between biomarkers in discerning the disease groups. High-confidence classifiers in these network abstractions comprised of host responses to microbial infection elucidated their critical role in discerning the disease groups. Conclusions Host adaptive immune responses to the oral colonization/infection contribute significantly to creating the profiles specific for periodontitis patients with potential to assist in defining patient-specific risk profiles and tailored interventions.

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“…Some studies show significant changes in values in crevicular fluid when periodontal disease is in an advanced stage and / or aggressive (20) and even in cases of peri-implant pathology as perimplantitis (33), showing a positive correlation between probing depth and the presence of IL-8 (34). …”

Section: Discussionmentioning

confidence: 99%

“…IL-8 plays an important role in the regulation of neutrophil function (19). Lütfioglu et al in 2015 linked the increase in IL-8 in the presence of periodontal disease, this being higher in chronic aggressive periodontitis and gingivitis (20). …”

Section: Introductionmentioning

confidence: 99%

Effectiveness of flossing loops in the control of the gingival health

et al. 2017

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BackgroundOne of the key factor in the good condition of periodontal tissues is their daily hygiene. Oral hygiene techniques such brushing and a good interdental hygiene by correct flossing are very important. The aim of this study is to compare the use of dental floss in a loop vs traditional floss in the control of Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8).Material and MethodsA comparative study of 40 patients in which each patient was his own control, using during 45 days each one of the devices (new loop floss and conventional floss) of interdental hygiene analysed. Data for Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8)were collected and measured in every visit for every type of interdental hygiene device.ResultsOur data indicates that the rate of Turesky´s Plaque Index presented statistically significant differences between groups (loop: 1.66 ± 0.8; traditional: 1.12 ± 0.8; p<0.0001). The rest of the indices studied showed no statistically significant differences.ConclusionsThe creation of new dental floss designs try to make their use easier and more sensitive, and plaque removal more effective. The loop design can facilitate interdental hygiene, reaching similar effectiveness than traditional floss, improving some indicators, such as Turesky´s Plaque Index. Key words:Dental floss, bacterial plaque, loop floss, plaque index, periodontal diseases.

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Gingival crevicular fluid interleukin‐8 and lipoxin A₄ levels of smokers and nonsmokers with different periodontal status: a cross‐sectional study

Abstract: The study findings suggest that the observed increases in gingival crevicular fluid IL-8 levels and decreases in gingival crevicular fluid LxA4 levels reflect changes in immune and inflammatory responses that occur as a result of smoking.

Cited by 21 publications

References 61 publications

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Integrated biomarker profiling of smokers with periodontitis

Effectiveness of flossing loops in the control of the gingival health

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Gingival crevicular fluid interleukin‐8 and lipoxin A4 levels of smokers and nonsmokers with different periodontal status: a cross‐sectional study

Abstract: The study findings suggest that the observed increases in gingival crevicular fluid IL-8 levels and decreases in gingival crevicular fluid LxA4 levels reflect changes in immune and inflammatory responses that occur as a result of smoking.

Cited by 21 publications

References 61 publications

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

Integrated biomarker profiling of smokers with periodontitis

Effectiveness of flossing loops in the control of the gingival health

Contact Info

Product

Resources

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Gingival crevicular fluid interleukin‐8 and lipoxin A₄ levels of smokers and nonsmokers with different periodontal status: a cross‐sectional study