Ginkgo biloba and its potential role in glaucoma

Kang, Jessica; Lin, Shan

doi:10.1097/icu.0000000000000459

Cited by 43 publications

(33 citation statements)

References 53 publications

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“…However, Guo et al (2014) did not show a statistically significant difference in visual field outcomes after Ginkgo biloba supplementation in Chinese patients. These conflicting reports suggest that racial differences may also play an important role ( Kang and Lin, 2018 ). In addition to antioxidant properties, Ginkgo biloba increases blood flow through vasodilation and reduces blood viscosity ( Kang and Lin, 2018 ).…”

Section: Factors Regulating the Redox Statusmentioning

confidence: 99%

“…These conflicting reports suggest that racial differences may also play an important role ( Kang and Lin, 2018 ). In addition to antioxidant properties, Ginkgo biloba increases blood flow through vasodilation and reduces blood viscosity ( Kang and Lin, 2018 ). The safety and efficacy of a combination of antioxidants and anti-inflammatory agents in OAG patients are currently under evaluation in a phase I clinical trial (NCT02984813) (Table 2 ).…”

Section: Factors Regulating the Redox Statusmentioning

confidence: 99%

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The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration

et al. 2018

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Retinal neurons are not able to undergo spontaneous regeneration in response to damage. A variety of stressors, i.e., UV radiation, high temperature, ischemia, allergens, and others, induce reactive oxygen species production, resulting in consecutive alteration of stress-response gene expression and finally can lead to cell apoptosis. Neurons have developed their own endogenous cellular protective systems. Some of them are preventing cell death and others are allowing functional recovery after injury. The high efficiency of these mechanisms is crucial for cell survival. In this review we focus on the contribution of the most recently studied endogenous neuroprotective factors involved in retinal ganglion cell (RGC) survival, among which, neurotrophic factors and their signaling pathways, processes regulating the redox status, and different pathways regulating cell death are the most important. Additionally, we summarize currently ongoing clinical trials for therapies for RGC degeneration and optic neuropathies, including glaucoma. Knowledge of the endogenous cellular protective mechanisms may help in the development of effective therapies and potential novel therapeutic targets in order to achieve progress in the treatment of retinal and optic nerve diseases.

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Section: Factors Regulating the Redox Statusmentioning

confidence: 99%

Section: Factors Regulating the Redox Statusmentioning

confidence: 99%

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration

et al. 2018

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“…Ginkgo biloba extract (GBE) has been tested in the treatment of various medical conditions [ 69 ], including glaucoma [ 70 , 71 ]. GBE exhibits a myriad of pharmacological properties making it relevant to the pathogenesis of glaucoma.…”

Section: Individual Dietary Componentsmentioning

confidence: 99%

The Role of Diet in Glaucoma: A Review of the Current Evidence

Owaifeer

Taisan

2018

Ophthalmol Ther

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Intraocular pressure (IOP) reduction by medications, laser, or surgery remains the mainstay of treatment in glaucoma. However, the role of complementary and alternative medicine (CAM) in glaucoma has received great interest from both patients and ophthalmologists. Previous evidence suggests that diet, a major domain of CAM, can influence an individual’s IOP level. Furthermore, certain dietary components have been linked to the incidence and progression of glaucoma. In this review, we aim to provide a summary of the current evidence regarding the role of obesity, certain dietary components, and dietary supplements in glaucoma.

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“…These beneficial effects can be explained by antioxidant and vascular protector properties, which result in improved ocular blood flow after being administered. Despite extensive information, more studies are needed to provide conclusive evidence [99]. Terpenes and flavonoids are the main compounds responsible for the antioxidant ability of GBEs used against glaucoma [100].…”

Section: Glaucomamentioning

confidence: 99%

Neuroprotective Potential of Ginkgo biloba in Retinal Diseases

et al. 2019

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Like other tissues of the central nervous system, the retina is susceptible to damage by oxidative processes that result in several neurodegenerative disease such as age-related macular degeneration, diabetic retinopathy, glaucoma, ischaemic retinal disease, retinal disease produced by light oxidation, and detached retina, among other diseases. The use of antioxidant substances is a solution to some health problems caused by oxidative stress, because they regulate redox homeostasis and reduce oxidative stress. This is important for neurodegeneration linked to oxidation processes. In line with this, Ginkgo biloba is a medicinal plant with excellent antioxidant properties whose effects have been demonstrated in several degenerative processes, including retinal diseases associated with neurodegeneration. This review describes the current literature on the role of ginkgo in retinal diseases associated with neurodegeneration. The information leads to the conclusion that G. biloba extracts might be a good option to improve certain neurodegenerative retinal diseases, but more research is needed to determine the safety and efficacy of G. biloba in these retinal degenerative processes.

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Ginkgo biloba and its potential role in glaucoma

Cited by 43 publications

References 53 publications

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration

The Role of Diet in Glaucoma: A Review of the Current Evidence

Neuroprotective Potential of Ginkgo biloba in Retinal Diseases

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