Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

Zhang, Haihua; Shi, Qiumei; Nan, Weixiao; Wang, Yaqi; Wang, Shiyong; Yang, Fenghuan; Li, Guangyu

doi:10.1002/biof.1562

Cited by 12 publications

(13 citation statements)

References 28 publications

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“…In many mammals, hair follicles undergo a variety of morphological changes at different times, with certain regularities that exhibit periodicity (anagen, catagen, telogen). Hair growth has been studied in many animal models, including mice ( Hansen et al, 1984 ; Slominski et al, 1994 ; Kwack et al, 2019 ), American mink ( Zhang et al, 2019a ), rabbit ( Zhao et al, 2019 ), yak ( Song et al, 2019 ), and goat ( Meyer et al, 1997 ). Following development from stem cells, hair follicles undergo rapid and cyclical growth, and are surrounded by dermal fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Zhao

Li²,

Liu

et al. 2020

Front. Genet.

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Long non-coding RNAs (lncRNA) and microRNAs (miRNA) are new found classes of non-coding RNAs (ncRNAs) that are not translated into proteins but regulate various cellular and biological processes. In this study, we conducted a transcriptomic analysis of ncRNA and mRNA expression in Aohan fine wool sheep (AFWS) at different growth stages (embryonic day 90, embryonic day 120, and the day of birth), and explored their relationship with wool follicle growth. In total, 461 lncRNAs, 106 miRNAs, and 1,009 mRNAs were found to be differentially expressed during the three stages of wool follicle development. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to clarify the roles of the differentially expressed lncRNA, miRNA, and mRNA in the different stages of wool follicle development. Quantitative real-time PCR (qRT-PCR) was used to validate the results of RNA-seq analysis. lncRNA (MSTRG.223165) was found to act as a competing endogenous RNA (ceRNA) and may participate in wool follicle development by acting as an miR-21 sponge. Network prediction implicated the MSTRG.223165-miR-21- SOX6 axis in the wool follicle development. The targeting relationships of miR-21 with SOX6 and MSTRG.223165 were validated in dual-luciferase assays. This is the first report indicating the association of the lncRNA–miRNA–mRNA network with wool follicle development in AFWS. This study provides new insights into the regulation of the wool follicle growth and represents a solid foundation for wool sheep breeding programs.

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Section: Discussionmentioning

confidence: 99%

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Zhao

Li²,

Liu

et al. 2020

Front. Genet.

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“…These ginkolides, at a concentration of 50 µM, also elevated the expression of β-catenin and downregulated the expression of DKK1 in DP cells. However, the hair growth promoting potential of these compounds in vivo is yet to be reported [ 71 ]. Morroniside, an iridoid glycoside extracted from Cornus officinalis , possesses diverse biological activities.…”

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

141

105

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Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

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“…Up-regulation of GSK/β-catenin signaling in Prdx2 -/knockout DMSCs. GSK3β/β-catenin is involved in various aspects of cell growth and differentiations through regulating the cell cycle related protein expressions (19)(20)(21)(22). Our findings suggest that PRDX2 gene knockout could dramatically inhibit the cell growth by affect the cell cycle related proteins expressions (Figure 3), we hypotheses that PRDX2 knockout may also affect the GSK/β-catenin signaling pathway.…”

Section: Deletion Of Prdx2 Increases G 0 /G 1 Cell-cycle Arrest Ofmentioning

confidence: 66%

Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G₀/G₁ Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling

Han

Jin

et al. 2019

In Vivo

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Background/Aim: Dermal mesenchymal stem cells (DMSCs) are pluripotent stem cells found in the skin which maintain the thickness of the dermal layer and participate in skin wound healing. Materials and Methods: The MTT assay was performed to detect cell proliferation and cell-cycle progression and cell-surface markers were assessed by flow cytometry. The levels of proteins in related signaling pathways were detected by western blotting assay and the translocation of β-catenin into the nucleus were detected by immunofluorescence. Red oil O staining was performed to examine the differentiational ability of DMSCs. Results: Knockout of PRDX2 inhibited DMSC cell growth, and cell-cycle arrest at G 0 /G 1 phase; p16, p21 and cyclin D1 expression levels in Prdx2 knockout DMSCs were significantly increased. Furthermore, AKT phosphorylation were significantly increased in Prdx2 knockout DMSCs, GSK3β activity were inhibited, result in β-Catenin accumulated in the nucleus. Conclusion: In conclusion, these results demonstrated that PRDX2 plays a pivotal role in regulating the proliferation of DMSCs, and this is closely related to the AKT/glycogen synthase kinase 3 beta/β-catenin signaling pathway. Skin has a strong capacity for repair and regeneration due to the fact that it contains various stem cells, such as epidermal stem cells, skin-derived precursors and dermal mesenchymal stem cells (DMSCs) (1, 2). DMSCs play two major roles, one is as a direct source of fibroblasts, and the other is to secrete a variety of cytokines which promote fibroblasts to produce collagen and elastin (3). Therefore, the function of DMSCs plays decisive role in skin development and wound repair (4). Peroxiredoxin 2 (PRDX2) is wildly distributed in various tissues and cells, and functions as a scavenger of reactive oxygen species (ROS) (5, 6). Our previous study showed that 133 This article is freely accessible online.

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Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

Cited by 12 publications

References 28 publications

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G₀/G₁ Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling

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Ginkgolide B and bilobalide promote the growth and increase β‐catenin expression in hair follicle dermal papilla cells of American minks

Cited by 12 publications

References 28 publications

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Transcriptomic Analysis Reveals the Involvement of lncRNA–miRNA–mRNA Networks in Hair Follicle Induction in Aohan Fine Wool Sheep Skin

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G0/G1 Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling

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Deletion of Peroxiredoxin II Inhibits the Growth of Mouse Primary Mesenchymal Stem Cells Through Induction of the G₀/G₁ Cell-cycle Arrest and Activation of AKT/GSK3β/β-Catenin Signaling