Ginseng extract attenuates early MRI changes after status epilepticus and decreases subsequent reduction of hippocampal volume in the rat brain

Quantification and reproducibility assessment of the regional brain T2 relaxation in naïve rats at 7T

“…We believe that the most crucial parameter affecting the precision of T 2 estimation is the TR, as the studies with shortest TR reported the smallest T 2 s (Table ). The only article out of all those selected above used long TR of 6 seconds (like in our study) and showed T 2 values very similar to our findings. A shorter TR value leads to increased T 1 ‐weighting of the acquired data and possible systemic bias, which may cause misestimation of T 2 values.…”

“…Table summarizes some of these numbers. For example, the averaged T 2 value of hippocampus varied from 47.9 msec to 52.28 to about 56 to about 60 . In comparison, we are reporting T 2 values in the same area at 58.27 msec.…”

A Multicenter Preclinical MRI Study: Definition of Rat Brain Relaxometry Reference Maps

“…Altogether, reported values are in good agreement with several recent studies (Del Bigio et al, 2011, Gigliucci et al, 2014, Koundal et al, 2015, Liachenko and Ramu, 2017, Suleymanova et al, 2014. In conclusion, we have demonstrated the feasibility of multicenter preclinical studies, sharing raw data and processing pipelines between distributed centers.…”

“…They show that T1 relaxation time increases with magnetic field while T2 relaxation time decreases (de Graaf et al, 2006, Wright et al, 2008, van de Ven et al, 2007. Some values have been reported in the literature for few brain regions (Barbier et al, 2005, Behroozi et al, 2018, Cremillieux et al, 1998, Del Bigio et al, 2011, Gigliucci et al, 2014, Koundal et al, 2015, Liachenko and Ramu, 2017, Suleymanova et al, 2014, but no consensus has been reached yet about values of reference for specific rat brain regions. To define such reference maps, a large number of brain structures or regions should be considered and a sufficient number of animals should be included to reflect inter-individual variability.…”

In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T

“…These differences between species most likely are caused by species‐dependent differences in neuro‐ and cytoarchitecture. The rodent cortex, just like that of all mammals, can be divided into two major components: gray matter and white matter . Gray matter mainly is composed of cell bodies as well as neuropil and represents the major information‐processing component of the forebrain.…”