Ginsenoside compound K- a potential drug for rheumatoid arthritis

Tang, Mengshi; Xie, Xiaoqing; Yang, Yong‐Yu; Li, Fen

doi:10.1016/j.phrs.2021.105498

Cited by 32 publications

(11 citation statements)

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“…We performed GO and KEGG enrichment analyses to explore the biological functions of the genes screened by WGCNA and Cox regression. The top terms of GO analysis were all associated with immune regulation and function ( 33 ); the terms of KEGG analysis were associated with immune disease ( 34 , 35 ) and immune regulation.…”

Section: Discussionmentioning

confidence: 99%

HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis

et al. 2022

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Colorectal cancer (CRC) is the most common digestive tumor in the world and has a high mortality rate. The development and treatment of CRC are related to the immune microenvironment, but immune response-related prognostic biomarkers are lacking. In this study, we used The Cancer Genome Atlas (TCGA) to explore the tumor microenvironment (TME) and weighted gene coexpression network analysis (WGCNA) to identify significant prognostic genes. We also identified differentially expressed genes in the TCGA data and explored immune-related genes and transcription factors (TFs). Then, we built a TF regulatory network and performed a comprehensive prognostic analysis of an lncRNA-associated competitive endogenous RNA network (ceRNA network) to build a prognostic model. CCR8 and HAMP were identified both in the WGCNA key module and as immune-related genes. HAMP had good prognostic value for CRC and was highly expressed in CRC tissues and had a negative correlation with CD4+ T cells and M0 macrophages based on immunohistochemistry and immunofluorescence staining of clinical specimens.We found that HAMP had high prognostic and therapeutic target value for CRC and was associated with liver metastasis. These analysis results revealed that HAMP may be a candidate immune-related prognostic biomarker for CRC.

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Section: Discussionmentioning

confidence: 99%

HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis

et al. 2022

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“…77 This could lead to a decrease in tumor necrosis factor-α (TNF-α) and tumor necrosis factor R2 (TNFR2), down-regulating their proliferation and migration and inhibiting hepatocellular carcinoma. 78…”

Section: Glucocorticoid-like Effects Of Ginsenosidesmentioning

confidence: 99%

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Li,

Zhao,

Wang

et al. 2024

Food Funct.

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“…Many factors, including impaired IL-6-related iron use, drug-related hepatotoxicity and hematology, and gastrointestinal problems, are causes of rheumatoid anemia [ 108 , 109 ]. The hemoglobin concentration of erythrocytes and red blood cells in the peripheral blood of AIA rats was reduced compared to that of normal rats [ 110 ]. GLP selectively binds to bone marrow stromal cells, stimulates the secretion of hematopoietic growth factors, and enhances the clonogenic activities of hematopoietic and stromal cells to promote hematopoiesis in mice [ 111 ].…”

Section: Resistance Of Glp On Anemiamentioning

confidence: 99%

Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides

Meng

Yao

Zhang³

et al. 2023

Molecules

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Rheumatoid arthritis (RA) is a chronic and autoimmune disease characterized by inflammation, autoimmune dysfunction, and cartilage and bone destruction. In this review, we summarized the available reports on the protective effects of Ganoderma lucidum polysaccharides (GLP) on RA in terms of anti-inflammatory, immunomodulatory, anti-angiogenic and osteoprotective effects. Firstly, GLP inhibits RA synovial fibroblast (RASF) proliferation and migration, modulates pro- and anti-inflammatory cytokines and reduces synovial inflammation. Secondly, GLP regulates the proliferation and differentiation of antigen-presenting cells such as dendritic cells, inhibits phagocytosis by mononuclear macrophages and nature killer (NK) cells and regulates the ratio of M1, M2 and related inflammatory cytokines. In addition, GLP produced activities in balancing humoral and cellular immunity, such as regulating immunoglobulin production, modulating T and B lymphocyte proliferative responses and cytokine release, exhibiting immunomodulatory effects. Thirdly, GLP inhibits angiogenesis through the direct inhibition of vascular endothelial cell proliferation and induction of cell death and the indirect inhibition of vascular endothelial growth factor (VEGF) production in the cells. Finally, GLP can inhibit the production of matrix metalloproteinases and promote osteoblast formation, exerting protective effects on bone and articular cartilage. It is suggested that GLP may be a promising agent for the treatment of RA.

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Ginsenoside compound K- a potential drug for rheumatoid arthritis

Cited by 32 publications

References 50 publications

HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis

HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis

Ginsenoside – a promising natural active ingredient with steroidal hormone activity

Potential Anti-Rheumatoid Arthritis Activities and Mechanisms of Ganoderma lucidum Polysaccharides

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