Ginsenoside extract from ginseng extends lifespan and health span in<i>Caenorhabditis elegans</i>

Wang, Hui; Zhang, Shuai; Zhai, Lu; Sun, Liwei; Zhao, Daqing; Wang, Zeyu; Li, Xiangyan

doi:10.1039/d1fo00576f

Cited by 40 publications

(26 citation statements)

References 46 publications

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“…Rg1 and Re exhibited similar anti-aging effects as TGGR in Drosophila . Consistent with other studies, Rg1 and Re are the major components of Panax ginseng, which prolongs the lifespan of C. elegans ( Wang et al, 2021 ), and Rg1 prevents cognitive impairment and hippocampal senescence in a rat model of aging ( Zhou et al, 2020 ). In future studies, specific anti-aging effects of single saponins should be clarified, and synergistic studies of each saponin based on clear molecular mechanisms should be examined.…”

Section: Discussionsupporting

confidence: 89%

“…Therefore, ginsenosides have the potential to be used as an alternative natural medicine for anti-aging and life-prolonging effects. A recent study reported that total ginsenoside extract can prolong the lifespan and healthy lifespan of Caenorhabditis elegans ( C. elegans ) by activating anti-oxidation signaling pathways ( Wang et al, 2021 ). However, the use of ginsenoside extract for delaying human aging, its anti-aging activities, optimal dosage and means of administration in different species need further investigation, and its multi-target mechanism of action needs to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao

Liu

Zhang

et al. 2022

Front. Aging Neurosci.

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In an increasingly aged global population, achieving healthy life expectancy through natural and safe drug interventions is highly desirable. Here we show that total ginsenosides (TGGR), the main active components in the traditional Chinese medicine, ginseng, promote longevity across species. In Drosophila, an intriguing effect of TGGR on lifespan was the relatively narrow treatment window to elicit long-term benefits. TGGR administration during early adulthood, and especially during midlife, was sufficient to extend lifespan in both sexes. TGGR did not increase lifespan by reducing food intake or reproductive capacity; rather, TGGR increased the fertility of male Drosophila. TGGR augmented healthspan readouts associated with youth and with healthy aging, such as motility, intestinal barrier integrity, and biorhythm homeostasis. TGGR treatment also improved some types of stress resistance in both sexes, including increased tolerance to starvation and oxidation, and shifting “aged” gene expression patterns toward “healthy” patterns seen in the young. Gene expression, pharmacological and genetic epistatic analyses demonstrated that TGGR effects require normal expression of genes involved in insulin, TOR and MAPK signaling. The positive effects of TGGR on both healthspan and lifespan, coupled with its mechanism of action via evolutionarily conserved signaling pathways, demonstrate it to be a promising anti-aging drug.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Zhao

Liu

Zhang

et al. 2022

Front. Aging Neurosci.

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“…Ginseng extract can resist the negative effects of heat stress [16]. Studies on C. elegans have shown the promising efficacy of certain saponins in reversing age-related declines via antioxidant regulation and longevity signaling pathways [17]. Sun Ginseng can effectively inhibit the proliferation and differentiation of adipocytes and can reduce the fat accumulation in C. elegans, which also suggests that the active substance in ginseng that plays the function of reducing the fat accumulation may be ginsenosides [18].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway

Lin

et al. 2021

IJMS

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Panax ginseng is a valuable traditional Chinese medicine in Northeast China. Ginsenoside, the active component of ginseng, has not been investigated much for its effects on aging and its underlying mechanism(s) of action. Here, we investigated the effects of total ginsenoside (TG), a mixture of the primary active ginsenosides from Panax ginseng, on the lifespan of Caenorhabditis elegans (C. elegans). We found that TG extended the lifespan of C. elegans and reduced lipofuscin accumulation. Moreover, TG increased the survival of C. elegans in response to heat and oxidative stress via the reduction of ROS. Next, we used RNA-seq to fully define the antiaging mechanism(s) of TG. The KEGG pathway analysis showed that TG can prolong the lifespan and is involved in the longevity regulating pathway. qPCR showed that TG upregulated the expression of nrh-80, daf-12, daf-16, hsf-1 and their downstream genes. TG also reduced the fat accumulation and promoted lipid metabolism. Moreover, TG failed to extend the lifespan of daf-16 and hsf-1 mutants, highlighting their role in the antiaging effects of TG in C. elegans. The four main constitution of TG were then confirmed by HPLC and included ginsenoside Re, Rg1, Rg2 and Rd. Of the ginsenosides, only ginsenoside Rd prolonged the lifespan of C. elegans to levels comparable to TG. These findings provided mechanistic insight into the antiaging effects of ginsenoside in C. elegans.

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“…The activation of the Nrf2 signaling pathway plays an important role in the antioxidant process ( 29 ). The antioxidant activity is closely related with the traditional use of Baizhu for improving longevity ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

Sesquiterpene Lactams and Lactones With Antioxidant Potentials From Atractylodes macrocephala Discovered by Molecular Networking Strategy

Wang

Zhao

et al. 2022

Front. Nutr.

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Atractylodes macrocephala rhizome (called Bái-zhú in China) has a long history as a functional food and herbal medicine in East Asia, especially China. Sesquiterpenoids are one of the main active compounds of Atractylodes macrocephala rhizome. This study aimed to explore the unknown sesquiterpenoids of A. macrocephala rhizome using a molecular networking strategy. Two new nitrogen-containing sesquiterpenoids, atractylenolactam A (1) and atractylenolactam B (2), and 2 new sesquiterpene lactones, 8-methoxy-atractylenolide V (6) and 15-acetoxyl atractylenolide III (7), along with 12 known analogs (3-5 and 8-16) were discovered and isolated. All the structures were assigned based on detailed spectroscopic analyses. The absolute configurations of 1, 2, 6, and 7 were established by time-dependent density functional theory ECD (TDDFT-ECD) calculations. All these compounds had different degrees of concentration-dependent activating effects on nuclear-factor-E2-related factor-2 (Nrf2).

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Ginsenoside extract from ginseng extends lifespan and health span inCaenorhabditis elegans

Abstract: Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans through activating NRF2/SKN-1, SIRT1/SIR 2.1, and FOXO/DAF-16 signaling pathways.

Cited by 40 publications

References 46 publications

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Studies on the Regulation and Molecular Mechanism of Panax Ginseng Saponins on Senescence and Related Behaviors of Drosophila melanogaster

Ginsenoside Prolongs the Lifespan of C. elegans via Lipid Metabolism and Activating the Stress Response Signaling Pathway

Sesquiterpene Lactams and Lactones With Antioxidant Potentials From Atractylodes macrocephala Discovered by Molecular Networking Strategy

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