Ginsenoside metabolite compound K exerts anti-inflammatory effect via suppressing T cell activation
Abstract:Ginsenoside metabolite compound K (CK) is a metabolite of ginsenoside, and belongs to dammarane-type triterpene saponins according to its structure. It has been reported that CK exerts anti-inflammatory activity. Our previous studies showed that CK alleviated adjuvant-induced arthritis (AA) and collagen-induced arthritis (CIA) via suppressing T cell activation. Our recent study showed that the inhibitory effect of CK on T cell activation was due to suppressing CCL21-CCR7-mediated migration of dendritic cells (… Show more
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