2020
DOI: 10.1097/fjc.0000000000000775
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Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein–Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis

Abstract: Oxidative low-density lipoprotein (ox-LDL) induces endothelium senescence and promotes atherosclerosis. Ginsenoside Rb1 (gRb1) has been proved to protect human umbilical vein cells (HUVECs), but its effect on ox-LDL–induced endothelium senescence and the underlying mechanism remains unknown. This study is to explore the involvement of the SIRT1/Beclin-1/autophagy axis in the effect of gRb1 on protecting endothelium against ox-LDL–induced senescence. Hyperlipidemia of Sprague Dawley rats was induced by high-fat… Show more

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Cited by 30 publications
(21 citation statements)
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“…OxLDL is a commonly used inducer of endothelial cell senescence. In this regard, ginsenoside Rb1 exerts protection against endothelial cell senescence through the SIRT1/Beclin-1/autophagy axis ( 67 ). In addition, GW9508, an agonist of GPR120, has been shown to improve oxLDL-induced cell cycle arrest.…”
Section: Oxldl and Endothelial Cell Dysfunctionmentioning
confidence: 99%
“…OxLDL is a commonly used inducer of endothelial cell senescence. In this regard, ginsenoside Rb1 exerts protection against endothelial cell senescence through the SIRT1/Beclin-1/autophagy axis ( 67 ). In addition, GW9508, an agonist of GPR120, has been shown to improve oxLDL-induced cell cycle arrest.…”
Section: Oxldl and Endothelial Cell Dysfunctionmentioning
confidence: 99%
“…Ginsenosides are the main active ingredients of Panax ginseng , a famous medicine known as the “King of Herbs” in Asian countries, and are mainly responsible for therapeutic and pharmacologic properties against cardiovascular and neurological disorders. It reported that multiple ginsenosides were found to activate SIRT1, including ginsenosides Rc, Rb2, F1, and Rg1, against oxidative damage, senescence, , cancer, inflammation, and metabolic diseases . Among the ginsenosides, ginsenoside Rc was reported to target mitochondrial functions, including free-radical scavenging, ATP content enhancement, and oxygen consumption recovery. , However, to our knowledge, how ginsenoside Rc interacts with SIRT1 to regulate glucose oxidation and mitochondrial biosynthesis in cardiomyocytes and neurons under physiological or I/R-injured conditions has not been clearly investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Macrophages form cholesterol-rich foam cells by phagocytosing oxidized LDLs, which is the main factor for atherosclerotic lesions. In vitro, Rb 1 can alleviate ox-LDL-induced vascular endothelium senescence via the SIRT1/Beclin-1/autophagy axis [ 71 ]. Macrophages can differentiate into two antagonistic subtypes: M1 and M2, of which pro-inflammatory M1 macrophages can lead to a more vulnerable plaque, whereas anti-inflammatory M2 macrophages have protective effects.…”
Section: Cardiovascular Systemmentioning
confidence: 99%