Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

Zhang, Haihua; Su, Yongmei; Wang, Jiantao; Gao, Ying; Yang, Fenghuan; Li, Guangyu; Shi, Qiumei

doi:10.1016/j.lfs.2019.05.033

Cited by 38 publications

(34 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Yellow node represents circRNA, purple node represents miRNA. Edge denotes the relationship between circRNA and miRNA source genes of these circRNAs (AKT3, TGFBR1, SMAD2, SOS2, RB1, EZH1, and FGFR2) were reported to participate in the growth process of hair follicles [36][37][38][39][40][41][42][43]. Comparison between our results and those of previous studies suggests that the selected circRNAs might play an important role in the signaling pathways during different stages of SF development in AFWS.…”

Section: Discussionsupporting

confidence: 60%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

et al. 2020

View full text Add to dashboard Cite

Background: Aohan fine wool sheep (AFWS) is a historically bred fine wool sheep, cultivated in China. The wool has excellent quality and good textile performance. Investigating the molecular mechanisms that regulate wool growth is important to improve wool quality and yield. Circular RNAs (circRNAs) are widely expressed non-coding RNAs that can act as competitive endogenous RNAs (ceRNAs) to bind to miRNAs. Although circRNAs have been studied in many fields, research on their activity in sheep wool follicles is limited. To understand the regulation of circRNAs in the growth of fine wool in sheep, we used RNA-Seq to identify circRNAs in sheep shoulder skin samples at three developmental stages: embryonic day 90 (E90d), embryonic day 120 (E120d), and at birth (Birth). Results: We identified 8753 circRNAs and found that 918 were differentially-expressed. We then analyzed the classification and characteristic of the circRNAs in sheep shoulder skin. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified the source genes of circRNAs, which were mainly enriched in cellular component organization, regulation of primary metabolic processes, tight junctions, and the cGMP-PKG and AMPK signaling pathways. In addition, we predicted interactions between 17 circRNAs and eight miRNAs, using miRanda software. Based on the significant pathways, we speculate that circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, and circ_0007826 might play an important role in regulating wool follicle growth in AFWS. Seven circRNAs were randomly selected to validate the RNA-Seq results, using qRT-PCR. Conclusion: Our results provide more information about circRNAs regulation of wool follicle development in AFWS, and establish a solid foundation for future research.

show abstract

Section: Discussionsupporting

confidence: 60%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In our study, seven circRNAs (circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, and circ_0007826) were identified based on the significant KEGG pathways. The source genes of these circRNAs (AKT3, TGFBR1, SMAD2, SOS2, RB1, EZH1, and FGFR2) were reported to participate in the growth process of hair follicles [36][37][38][39][40][41][42][43]. Comparison between our results and those of previous studies suggests that the selected circRNAs might play an important role in the signaling pathways during different stages of SF development in AFWS.…”

Section: Validation Of Circrnas Expression By Qrt-pcrsupporting

confidence: 57%

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Zhao

Liu

Han

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Aohan fine wool sheep (AFWS) is a historically bred fine wool sheep, cultivated in China. The wool has excellent quality and good textile performance. Investigating the molecular mechanisms that regulate wool growth is important to improve wool quality and yield. Circular RNAs (circRNAs) are non-coding RNAs that are widely expressed, and can act as a competitive endogenous RNAs (ceRNAs) to bind to miRNAs. Although circRNAs have been studied in many fields, research on their activity in sheep wool follicles is limited. To understand the regulation of circRNAs in the growth of fine wool in sheep, we used RNA-seq to identify circRNAs in sheep shoulder skin samples at three developmental stages: embryonic day 90 (E90d), embryonic day 120 (E120d), and at birth (Birth). Results: We identified 8,753 circRNAs and found that 918 were differentially-expressed. We then analyzed the classification and characteristic of the circRNAs in sheep shoulder skin. Using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG), we identified the source genes of circRNAs, which were mainly enriched in cellular component organization, regulation of primary metabolic processes, tight junctions, and the cGMP-PKG and AMPK signaling pathways. In addition, we predict interactions between 17 circRNAs and eight miRNAs, using miRanda software. Based on the significant pathways, we speculate that circ_0005720, circ_0001754, circ_0008036, circ_0004032, circ_0005174, circ_0005519, circ_0007826 might play an important role in regulating wool follicle growth in AFWS. Seven circRNAs were randomly selected, and have validated the results of the RNA-seq by qRT-PCR. Conclusion: Our results provide more information about circRNAs in regulating wool follicle development in AFWS, and establish a solid foundation for future research.

show abstract

“…Coumaric and sinapic acids are both hydroxycinnamic acids, and coumaric acid was identified in all three ethyl acetate extracts of F. berteroana, C. inophyllum and B. pilosa ( Table 1 ), further pointing towards a potential Wnt/β-catenin target stimulation of hair growth of our extracts and fractions. Several other natural compounds have shown hair growth activity such as a tannin, corilagin [ 48 , 61 ], chalcones with 3-deoxysappanchalcone [ 67 ], terpenes, such as costunolide [ 68 ], or ginsenoside Rb1 [ 69 , 70 ]. A derivative of benzodiazepine named tianeptine was also found to have an effect on hair growth [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Hughes

Greff

et al. 2020

Molecules

View full text Add to dashboard Cite

Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts significantly increased proliferation of dermal papilla cells. Furthermore, LC-MS/MS analysis revealed a diversity of molecules, flavonoids, iridoids and organic acids, some known for hair-inducing properties. Finally, specific extracts and fractions of all three plants either upregulated CCND1, LEF1 and PPARD involved in stimulating hair follicle proliferation and/or lowered the gene expression levels of hair growth inhibiting factors, DKK1 and TGFB1. Our findings suggest that extracts from B. pilosa, C. inophyllum and F. berteroana are interesting candidates to stimulate hair growth.

show abstract

Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

Cited by 38 publications

References 47 publications

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Identification and characterization of circRNAs in the skin during wool follicle development in Aohan fine wool sheep

Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells

Contact Info

Product

Resources

About