Ginsenoside Rd: A promising target for ischemia-reperfusion injury therapy (A mini review)

Feng, Qiupeng; Ling, Lijing; Yuan, Hua; Guo, Zhiqiang; Ma, Jin

doi:10.1016/j.biopha.2023.116111

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2023.116111

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Ginsenoside Rd: A promising target for ischemia-reperfusion injury therapy (A mini review)

Qiupeng Feng,

Lijing Ling,

Hua Yuan

et al.

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2024

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Cited by 3 publications

References 48 publications

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Comprehensive review of perioperative factors influencing ferroptosis

Fan,

Zeng,

Feng

et al. 2024

Biomedicine & Pharmacotherapy

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Comprehensive review of perioperative factors influencing ferroptosis

Fan,

Zeng,

Feng

et al. 2024

Biomedicine & Pharmacotherapy

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A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity

Zare-Zardini,

Hedayati-Goudarzi,

Alizadeh

et al. 2024

BioMed Eng OnLine

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Ginseng Radix et Rhizoma enhanced the effect of metoprolol in chronic heart failure by inhibiting autophagy in male C57BL/6J mice

Zi-chang,

Xiao-ling,

et al. 2024

PLoS ONE

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Background Ginseng Radix et Rhizoma (GS) is frequently used as an adjuvant therapy for patients with heart failure (HF). Metoprolol is widely used in patients with HF. However, there is no report on the combined effects of GS and metoprolol in patients with HF. Objective This study investigated the combined effects of GS and metoprolol in male C57BL/6J mice with HF and the underlying mechanisms. Materials and methods We utilized a mouse myocardial HF model to measure the serum levels of creatine kinase (CK) and creatine kinase-MB form (CK-MB) using an automated biochemical analyzer. Lactate dehydrogenase (LDH) and cardiac troponin (cTnT) levels were determined using enzyme-linked immunosorbent assays. Autophagy of myocardial cells was evaluated using transmission electron microscopy, and changes in signal pathway proteins related to autophagy were analyzed by Western blotting. Results GS combined with metoprolol improved heart function, reduced heart damage, and decreased serum levels of CK, CK-MB, LDH, and cTnT. The combination of GS and metoprolol decreased autophagy in myocardial cells by reducing the levels of autophagy-related proteins (LC3, p62, Beclin1, and Atg5) and increasing the ratios of p-PI3K/PI3K, p-Akt/Akt, and p-mTOR/mTOR. Conclusion GS enhanced the anti-heart failure effect of metoprolol. Its mechanism of action might be related to the inhibition of autophagy mediated by the activation of the PI3K/Akt/mTOR pathway.

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Ginsenoside Rd: A promising target for ischemia-reperfusion injury therapy (A mini review)

Cited by 3 publications

References 48 publications

Comprehensive review of perioperative factors influencing ferroptosis

Comprehensive review of perioperative factors influencing ferroptosis

A review of cardioprotective effect of ginsenosides in chemotherapy-induced cardiotoxicity

Ginseng Radix et Rhizoma enhanced the effect of metoprolol in chronic heart failure by inhibiting autophagy in male C57BL/6J mice

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