Ginsenoside Rg1 improved learning and memory ability and reduces neuronal apoptosis in epileptic rats through ERK/CREB/BDNF signal pathway

Zhang, Jiawei; Zhu, Chengliang; Yun, Jimmy; Shen, Wangzhen; Su, Yan

doi:10.1016/j.bbrc.2023.07.004

Cited by 9 publications

(2 citation statements)

References 17 publications

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“…37 These compounds have various pharmacological properties, such as promoting learning and memory, 38 reducing in ammation and oxidative stress, 39,40 lowering Aβ levels, inhibiting tau protein hyperphosphorylation, 41,42 and decreasing apoptosis in neuronal cells. 43,44 Screening based on Ellman's method and HPLC-QTOF MS technique revealed that Zhimai steroidal saponins exhibit moderate or weak AChE inhibitory activity, 45 indicating their potential as an anti-AD drug. On the other hand, Diosgenin exerts its therapeutic effect on AD by modulating NOX 4/NOX 4-mediated oxidative stress and in ammatory responses.…”

Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking

Luo,

Pan,

Chen

et al. 2024

Preprint

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Alzheimer's disease (AD) is a neurodegenerative disease, and there have been no systematic studies of Polygonatum against Alzheimer's disease. This study aimed to identify the primary active components and potential mechanisms of action of Polygonatum in the treatment of AD through network pharmacology and molecular docking. Polygonatum's active ingredients and corresponding targets were identified using the Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). Disease targets of Alzheimer's disease (AD) were retrieved from the therapeutic target database (TTD), Online Mendelian Inheritance in Man(OMIM), GeneCards, and Disgenet databases. We constructed protein interaction PPI networks and performed Gene Ontology (GO) functional enrichment analysis as well as Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on common targets. As a result, a total of 10 active ingredients and 108 common targets were screened from Polygonatum. After analysis, 29 genes were identified as core genes. According to GO analysis, the core targets were found to be mainly involved in signal transduction, positive regulation of gene expression, and so on. The KEGG analysis revealed that the signaling pathways comprised pathways in cancer, pathways of neurodegeneration - multiple diseases, and PI3K-Akt signaling pathway. The molecular docking results indicated that ten of active ingredients from Polygonatum exhibited strong binding affinity with the six core targets that were screened before. This study confirms that the treatment of Alzheimer's disease with Polygonatum involves multi-targets and multi-pathway interactions, which provides a new perspective on the treatment of Alzheimer's disease and offers a theoretical basis for further research on the pathogenesis and treatment of AD.

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Section: Discussionmentioning

confidence: 99%

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking

Luo,

Pan,

Chen

et al. 2024

Preprint

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“…In addition, saponins in ginseng have antioxidant effects and anti-cancer effects and ameliorate intestinal mucosal damage by enhancing HUR and c-Myc levels [21,22]. Others have shown that saponins in ginseng, such as the ginsenoside Rg1, might have the effect of reducing neuronal apoptosis via ERK/CREB/BDNF signaling to improve learning and memory in epileptic rats [23]. However, there is currently limited literature on the study of ginseng flavor.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Identification of Bitter Compounds in Ginseng (Panax ginseng C. A. Mey.) Based on Preparative High Performance Liquid Chromatography, UPLC-Q-TOF/MS and Electronic Tongue

Chen,

Liao,

Wang

et al. 2024

Separations

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As a traditional Chinese medicinal herb, ginseng (Panax ginseng C. A. Mey.) is commonly used to treat common diseases, for example, esophageal cancer and myasthenia gravis. Furthermore, ginseng is also processed into a functional food additive that is utilized to improve the freshness of chicken soup and make health wine. Unfortunately, ginseng (Panax ginseng C. A. Mey.) has already shown a noticeable bitterness during its application process. In this research, the bitter substances in ginseng (Panax ginseng C. A. Mey.) after two common preparation processes (water extraction and ethanol extraction) were separated, purified and identified by preparative high performance liquid chromatography (prep-HPLC), high performance liquid chromatography with diode array detector (HPLC-DAD), ultra-performance liquid chromatography coupled with high-resolution quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) and an electronic tongue. The results indicated that compared with the other four bitter compounds, the ginsenoside Rb1 had the highest bitterness value, followed by 20(S)-ginsenoside Rg2, ginsenoside Rg1, ginsenoside Rf and ginsenoside Rb3. Upon the evaluation of results to reduce the bitterness of ginseng extract, we found that the composite embedding system of chitosan adsorption in the ginseng carrageenan gel microsphere (K/MC/MCG) could effectively reduce the bitterness.

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Traditional Herbal Medicine for Dementia Therapy

Sosa,

Hassan

2024

Nutritional Neurosciences

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Ginsenoside Rg1 improved learning and memory ability and reduces neuronal apoptosis in epileptic rats through ERK/CREB/BDNF signal pathway

Cited by 9 publications

References 17 publications

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking

Isolation and Identification of Bitter Compounds in Ginseng (Panax ginseng C. A. Mey.) Based on Preparative High Performance Liquid Chromatography, UPLC-Q-TOF/MS and Electronic Tongue

Traditional Herbal Medicine for Dementia Therapy

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