Ginsenoside Rg1 promotes peripheral nerve regeneration in rat model of nerve crush injury

Ginsenoside Rg1 Promotes the Migration of Olfactory Ensheathing Cells <i>via</i> the PI3K/Akt Pathway to Repair Rat Spinal Cord Injury

“…11,12,14,35) We further investigated how ginsenoside Rg1 improved the efficacy of OECs, which were used in the treatment of SCI. An increased frequency of NSE appearance decreased with neuronal injury.…”

“…The wide range of pharmacological actions of ginseng may be a result of the variety of its active ingredients-ginsenosides. 10) Ginsenosides, extracted from ginseng root, have been demonstrated to promote peripheral axonal regeneration, 11) and the neuroprotective effects of ginseng components in injured spinal cord tissues 12) or ischemic brains have been reported. 13) In previous studies, it has been reported that Rg1 protects neurons and promotes cell proliferation and axonal regeneration.…”

“…13) In previous studies, it has been reported that Rg1 protects neurons and promotes cell proliferation and axonal regeneration. 11,14) With a structure similar to glucocorticoids, ginsenoside Rg1 also regulates the phenotypic activity of glial cells. Furthermore, Rg1 offers protection to neuronal cells damaged as a result of SCI.…”

Ginsenoside Re Promotes Nerve Regeneration by Facilitating the Proliferation, Differentiation and Migration of Schwann Cells via the ERK- and JNK-Dependent Pathway in Rat Model of Sciatic Nerve Crush Injury

“…Up to now, more than 30 different ginsenosides have been purified from ginseng (Attele et al 1999). They can be divided into two classes, namely protopanaxatriol (Rg1, Rg2, Re, Rf, and Rh1) and protopanaxadiol (Rb1, Rb2, Rc, Rd, Rg3, Rh2, and Rh3) (Ma et al 2010). Ginsenoside Re (Re, C 53 H 90 O 22 ) is the main ingredient of ginseng berries and roots.…”

“…Through relieving the imbalance between thromboxane A 2 and prostacyclin in renal ischemia-reperfusion injury (RIRI), increasing the activity of antioxidant enzymes in serum and reducing oxygen free radical-mediated lipid peroxidation, Re seems to apply possibilities for reducing the damage of RIRI. It is widely reported that other ginsenosides have neuroprotective effect, such as GRg1 can prevent OGDR-induced PC12 cell apoptosis and partly reveal the mechanisms of the protective effect and also as a neuroprotective agent to promote peripheral nerve regeneration after SNC in rats (Huang et al 2014;Ma et al 2010). Rb1 can modulate local inflammation, as demonstrated by suppression of microglia activation, reduction of pro-inflammatory cytokines, and inhibition of the NF-jB pathway.…”