Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos

He, Long; Lee, Jun–Won; Jang, Jae Hyuk; Lee, Sung-Hoon; Nan, Mei Hua; Oh, Byung‐Chul; Lee, Sang Gu; Kim, Hong Hee; Soung, Nak-Kyun; Ahn, Jong Seog; Kim, Bo Yeon

doi:10.1016/j.bone.2012.03.022

Cited by 47 publications

(46 citation statements)

References 32 publications

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“…10,15,[26][27][28] Our results support previous studies that have demonstrated the preventive effects of PNS on trabecular bone deterioration.…”

Section: Fan Et Alsupporting

confidence: 95%

“…16,31 A previous cross-sectional study euthanized groups of animals at various time points after they had been ovariectomized or given a drug intervention. [10][11][12]26,27 The use of a simple two-point Dixon option presented here may represent a low-cost noninvasive method for quantifying fat fraction in bone marrow. In this study, we tried to investigate the effects of PNS on marrow adipogenesis using a longitudinal study design, which can provide earlier detection of marrow fat content changes compared with a crosssectional study.…”

Section: Fan Et Almentioning

confidence: 99%

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Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

et al. 2015

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“…10,15,[26][27][28] Our results support previous studies that have demonstrated the preventive effects of PNS on trabecular bone deterioration.…”

Section: Fan Et Alsupporting

confidence: 95%

Section: Fan Et Almentioning

confidence: 99%

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

et al. 2015

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“…Several health benefits of Rh2 have been reported due to its anti-inflammatory, antiGinsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells osteoclastogenic, anti-hyperglycemic and anticancer effects (10)(11)(12)(13)(14). The anticancer effect of Rh2 has been particularly observed in NSCLCs.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

An¹,

An²,

Kwon

et al. 2012

Oncology Reports

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Abstract. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer insensitive to chemotherapy. Efforts are, therefore, directed toward understanding the molecular mechanisms of chemotherapy insensitivity and the development of new anticancer drugs. Ginsenoside Rh2, one of the components in ginseng saponin, has been shown to have anti-proliferative effect on human NSCLC cells and is being studied as a therapeutic drug for NSCLC. microRNAs (miRNAs) are small, non-coding RNA molecules that play a key role in cancer progression and prevention. However, the miRNA portrait of ginsenoside Rh2-treated NSCLC cells has not yet been studied. In this study, we identified a unique set of changes in the miRNA expression profile in response to Rh2 treatment in the human NSCLC cell line A549. Using miRNA microarray analysis, we identified 44 and 24 miRNAs displaying changes in expression greater than 2-fold in Rh2-treated A549 cells. In addition, using an miRNA target prediction program, we discovered that these miRNAs are predicted to have several target genes related to angiogenesis, apoptosis, chromatic modification, cell proliferation and differentiation. Thus, these results may assist in the better understanding of the anticancer mechanism of Rh2 in NSCLC.

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“…TNF also activates the transcription of nuclear factor kappa B (NF-κB), which inhibits apoptosis via suppression of caspase-8 activation [23]. Interestingly, NF-κB is down-regulated and caspase-8 is activated following treatment with ginsenoside Rh2, which suggests the induction of apoptosis [17,25].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-α signaling pathway

Huang

Peng

Wang

et al. 2016

ABBS

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Ginsenoside Rh2, a triterpene saponin extracted from Panax ginseng, exhibits pharmacological activity against multiple cancers. However, the anticancer mechanism of ginsenoside Rh2 is unclear. In this study, we found that ginsenoside Rh2 effectively inhibits growth and induces apoptosis of HL-60 cells. Using microarray technology, we found that tumor necrosis factor-α (TNF-α) is clearly up-regulated. Furthermore, anti-TNF-α antibody relieved the Rh2-induced HL-60 cell apoptosis via suppression of caspase-8, caspase-9, and caspase-3 activation. In addition, TNF-α up-regulation was also observed in other Rh2-treated cancer cell lines. These results demonstrate that TNF-α plays a key role in ginsenoside Rh2-induced cell apoptosis.

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Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos

Cited by 47 publications

References 32 publications

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-α signaling pathway

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Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos

Cited by 47 publications

References 32 publications

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

Panax notoginseng saponins mitigate ovariectomy-induced bone loss and inhibit marrow adiposity in rats

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-&alpha; signaling pathway

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Ginsenoside Rh2 inhibits proliferation and induces apoptosis in human leukemia cells via TNF-α signaling pathway