Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11

Lang, Zhichao; Yu, Suhui; Hu, Yunzhang; Tao, Qiqi; Zhang, Jingnan; Wang, Haoyue; Zheng, Lei; Yu, Zhixian; Zheng, Jianjian

doi:10.1016/j.phymed.2023.154950

Cited by 21 publications

(5 citation statements)

References 32 publications

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“…Similarly, many bioactive chemicals ameliorate LF via suppressing HSC activation. 19,26,31–33 Phenomena above suggest that restraining HSC activation is a feasible strategy for combating LF. Based on previously published literatures, the concentration of EGT applied in cultured cells is around 10 μM, 34 while the dosage of EGT used in mice via gavage is around 15 mg kg −1 .…”

Section: Discussionmentioning

confidence: 99%

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Shu,

Lei,

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Shu,

Lei,

et al. 2023

Food Funct.

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“…Conversely, increasing the expression of HIF-1α and SLC7A11 suppressed ferroptosis in HSCs and attenuates the antifibrotic effects of sorafenib (Yuan et al, 2022a). Lang et al, (2023) found that GRh 2 upregulates IRF1 expression, leading to the inhibition of SLC7A11, thus resulting in ferroptosis and inactivation of HSCs. GRh2 improves liver fibrosis by enhancing HSC ferroptosis and suppressing hepatic inflammation.…”

Section: Regulation Of Ferroptosis Based On Lipid Peroxidation Interv...mentioning

confidence: 96%

Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

Tang,

Luo,

Zhu

et al. 2023

Front. Mol. Biosci.

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Fibrosis is a common pathological process that must take place for multiple chronic liver diseases to develop into cirrhosis and liver cancer. Liver fibrosis (LF) is regulated by various cytokines and signaling pathways in its occurrence and development. Ferroptosis is an important mode of cell death caused by iron-dependent oxidative damage and is regulated by iron metabolism and lipid peroxidation signaling pathways. In recent years, numerous studies have shown that ferroptosis is closely related to LF. As the main material secreted by the extracellular matrix, hepatic stellate cells (HSCs) are a general concern in the development of LF. Therefore, targeting HSC ferroptosis against LF is crucial. This review describes the current status of treating LF by inducing HSC ferroptosis that would aid studies in better understanding the current knowledge on ferroptosis in HSCs and the future research direction in this field.

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“…Ginsenoside Rh2 (G-Rh2), a kind of NAC extracted from ginseng, inhibited HSCs activation through the AKT-mTOR pathway [ 191 ]. A further study confirmed that G-Rh2 could also inhibit HSCs activation by enhancing ferroptosis through upregulating interferon regulatory factor 1 to inhibit SLC7A11 [ 192 ]. Wild bitter melon (WM), a wild variety of bitter melon, is rich in ethyl acetate, which has strong antioxidant activity [ 193 ].…”

Section: Nac Treat Liver Disease By Targeting Ferroptosismentioning

confidence: 99%

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Wu,

Zhu,

Liu

et al. 2024

Antioxidants

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Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation of ferrous ions (Fe2+) and lipid peroxides. As the metabolic hub of the body, the liver is crucial for iron storage and lipid metabolism. The liver seems to be closely related to ferroptosis through iron and lipid metabolism. Liver disease greatly threatens host health, and exploring effective interventions is essential. Mounting studies have demonstrated that ferroptosis is one of the possible pathogenic mechanisms involved in liver disease. Targeting ferroptosis may provide a promising opportunity for treating liver disease. However, drugs targeting ferroptosis are extremely limited. Therefore, it is an urgent need to develop new and safe ferroptosis regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, have recently shown great therapeutic potential in liver disease via modulating ferroptosis-related genes or pathways. Here, we outline the molecular mechanism of ferroptosis and systematically summarize the regulatory function of NAC on ferroptosis in liver disease. Finally, we discuss the application prospects and potential problems concerning NAC as ferroptosis regulators for managing liver disease.

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Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11

Cited by 21 publications

References 32 publications

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

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Ginsenoside Rh2 promotes hepatic stellate cell ferroptosis and inactivation via regulation of IRF1-inhibited SLC7A11

Cited by 21 publications

References 32 publications

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl4-induced liver fibrosis in mice

Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis

Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

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Product

Resources

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Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice

Ergothioneine suppresses hepatic stellate cell activation via promoting Foxa3-dependent potentiation of the Hint1/Smad7 cascade and improves CCl₄-induced liver fibrosis in mice