Glanders in donkeys (Equus asinus) in the state of Pernambuco, Brazil: a case report

Mota, Rinaldo Aparecido; Oliveira, Andréa Alice da Fonseca; Pinheiro, José Wilton; Silva, Leonildo Bento Galiza da; Brito, Marilene de Farias; Rabelo, Silvana Suely Assis

doi:10.1590/s1517-83822010000100021

Cited by 28 publications

(16 citation statements)

References 5 publications

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“…rity threat (7,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). The genetic relatedness between the organisms indicates that B. mallei evolved from B. pseudomallei through a process of genomic reduction (24)(25)(26)(27).…”

mentioning

confidence: 99%

Antibodies against In Vivo -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei

et al. 2017

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Burkholderia mallei, a facultative intracellular bacterium and tier 1 biothreat, causes the fatal zoonotic disease glanders. The organism possesses multiple genes encoding autotransporter proteins, which represent important virulence factors and targets for developing countermeasures in pathogenic Gram-negative bacteria. In the present study, we investigated one of these autotransporters, BatA, and demonstrate that it displays lipolytic activity, aids in intracellular survival, is expressed in vivo, elicits production of antibodies during infection, and contributes to pathogenicity in a mouse aerosol challenge model. A mutation in the batA gene of wild-type strain ATCC 23344 was found to be particularly attenuating, as BALB/c mice infected with the equivalent of 80 median lethal doses cleared the organism. This finding prompted us to test the hypothesis that vaccination with the batA mutant strain elicits protective immunity against subsequent infection with wild-type bacteria. We discovered that not only does vaccination provide high levels of protection against lethal aerosol challenge with B. mallei ATCC 23344, it also protects against infection with multiple isolates of the closely related organism and causative agent of melioidosis, Burkholderia pseudomallei. Passive-transfer experiments also revealed that the protective immunity afforded by vaccination with the batA mutant strain is predominantly mediated by IgG antibodies binding to antigens expressed exclusively in vivo. Collectively, our data demonstrate that BatA is a target for developing medical countermeasures and that vaccination with a mutant lacking expression of the protein provides a platform to gain insights regarding mechanisms of protective immunity against B. mallei and B. pseudomallei, including antigen discovery.

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mentioning

confidence: 99%

Antibodies against In Vivo -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei

et al. 2017

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“…Os equinos de qualquer idade são susceptíveis ao mormo, porém a doença acomete principalmente os animais idosos, debilitados, submetidos a trabalho excessivo e com condições sanitárias inadequadas, já o homem é hospedeiro acidental, sendo geralmente uma doença ocupacional (SCHELL et al, 2007). A disseminação ocorre principalmente por meio da contaminação de forragem, cochos e bebedouros por secreção oral e nasal de animais infectados (MOTA et al, 2010). Até o presente momento, não existe nenhuma vacina animal ou humano eficiente contra a infecção da Burkholderia mallei (CHAVES, 2009).…”

Section: O Que Pode Ser Feito Para Como Prevenção?unclassified

Enfermidades De Caráter Zoonótico Em Equinos De Carroça: Visão Dos Proprietários Da Periferia De Pelotas

Souza¹,

Nogueira²,

Bruhn³

et al. 2019

Exp. Ext.

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Nº 3 EXPRESSA EXTENSÃO | SET-DEZ, 2019RESUMO O objetivo do presente estudo foi estimar o conhecimento dos proprietários em situação de vulnerabilidade social em relação às enfermidades de carácter zoonótico de equinos utilizados em carroças, atendidos no ambulatório do Hospital de Clínicas Veterinária da UFPel. Foram entrevistados quinze proprietários pertencentes às famílias moradoras do loteamento Ceval do município de Pelotas, RS cadastradas no projeto de extensão "Ação Interdisciplinar de atenção a carroceiros e charreteiros na periferia de Pelotas". Para coleta de dados foram aplicadas a estes proprietários, por meio de entrevista, vinte e uma questões referentes às seguintes zoonoses: leptospirose, raiva, tétano e mormo. Através da análise descritiva dos dados observou-se que os entrevistados demonstraram maior nível de conhecimento quando questionados sobre leptospirose e tétano, enfermidades circulantes nestes ambientes devido à higiene precária das instalações e utensílios utilizados no manejo dos animais, enquanto o mormo e a raiva apresentaram os menores índices de conhecimento por parte dos entrevistados. Sendo assim, os conhecimentos sobre doenças de caráter zoonótico demonstrados por estes proprietários podem ser um reflexo das ações educativas juntamente com o atendimento clínico realizado no ambulatório do HCV-UFPel.Palavras-chave: Cavalo de tração. Saúde pública. Epidemiologia social.

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“…Acute glanders is most frequently observed in donkeys and mules (Mason, 1918; Udall, 1939; Hayes, 1968; Mota et al., 2010) and is fatal within few days to weeks (Minett, 1959). However, the susceptibility of mules to glanders has been suggested to be somewhat less compared to horses and donkeys (Davies, 1955) and disease may run subacute (Gulati and Gautam, 1962) and chronic course (Saxer, 1946).…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…Histologic lesions in equids may include lesions of granulomatosis or pyogranulomatosis in the lungs with inflammatory elements including macrophages, epithelioid cells and small foci of haemorrhage, oedema and aggregation of interlobular and intra‐alveolar fibrin. Vasculitis and thrombosis of the nasal blood vessels with neutrophilic granulocyte infiltration were observed (Miller et al., 1948; Popov et al., 1991; Mota et al., 2010). Bazargani et al.…”

Section: Pathogenesismentioning

confidence: 99%

Glanders in Animals: A Review on Epidemiology, Clinical Presentation, Diagnosis and Countermeasures

Khan

Wieler

Melzer

et al. 2012

Transboundary and Emerging Diseases

141

144

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Glanders in donkeys (Equus asinus) in the state of Pernambuco, Brazil: a case report

Cited by 28 publications

References 5 publications

Antibodies against In Vivo -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei

Antibodies against In Vivo -Expressed Antigens Are Sufficient To Protect against Lethal Aerosol Infection with Burkholderia mallei and Burkholderia pseudomallei

Enfermidades De Caráter Zoonótico Em Equinos De Carroça: Visão Dos Proprietários Da Periferia De Pelotas

Glanders in Animals: A Review on Epidemiology, Clinical Presentation, Diagnosis and Countermeasures

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