Glassworts as Possible Anticancer Agents Against Human Colorectal Adenocarcinoma Cells with Their Nutritive, Antioxidant and Phytochemical Profiles

Abstract

In this study, the possible uses of glassworts as potential food ingredients and their antiproliferative activity against colorectal adenocarcinoma cells together with their antioxidant and phytochemical profiles were investigated for the first time. MeOH extracts of five different taxa collected from different localities were screened for their antioxidant capacities by DPPH (IC 2.91 - 5.49 mg/ml) and ABTS (24.4 - 38.5 μmol TE/g extract) assays. Salicornia freitagii exhibited the highest DPPH radical scavenging activity. LC/MS/MS analysis displayed that vanillic acid and p-coumaric acid were two main phenolic compounds in the extract. Salicornia freitagii extracts also exhibited high antiproliferative activity against HT-29 (IC 1.67 mg/ml) and Caco-2 (IC 3.03 mg/ml) cells for 72 h. Mineral analysis indicated that all the species with different proportions of elemental components contained high amount of cations. These results indicate that investigated glassworts, with their high phenolic and mineral contents and also notable antioxidant and cytotoxic properties, may be utilized as a promising source of therapeutics.

In vitro Antioxidant and Cytotoxic Activities of Extracts of Endemic Tanacetum erzincanense Together with Phenolic Content by LC‐ESI‐QTOF‐MS

“…Due to the increase in cancer spread and the side effects of available chemotherapeutic drugs has forced scientists on investigations of natural‐based anticancer agents [7] . Many chemotherapeutic agents exhibit antioxidant potential, which are capable of preventing the formation of some human cancer types [8,9] .…”

Phytochemical Analysis and Biological Evaluation of Hypericum linarioides Bosse: in Vitro and in Silico Studies

“…Increase in cancer incidence and lack of anticancer drugs or maybe their some side effects have forced the researchers to investigate the natural‐based anticancer drugs especially in underdeveloped and developing countries as an available resource for health care [15] . Biological activity studies related with the extracts from medicinal plants revealed their good source of anti‐carcinogenic agents [6] . Thus, investigations on plant‐based secondary metabolites as well as crude extracts as an antioxidant and chemoprevention agent are still ongoing process.…”

“…[15] Biological activity studies related with the extracts from medicinal plants revealed their good source of anti-carcinogenic agents. [6] Thus, investigations on plant-based secondary metabolites as well as crude extracts as an antioxidant and chemoprevention agent are still ongoing process.…”

“…Different parts of the plants such as bark, leaves, flower, fruits, and seeds have been utilized as plant‐based natural constituent [4] . The plants possessing ethno pharmaceutical significance have been commonly studied for healing efficacy, such as diabetes, hypertension, cardiovascular, neurodegeneration and cancer, [5] and also they have been studied for their biological activities, like antimicrobial, antioxidant and cytotoxic properties [6] . Therefore, the studies on the isolation of bioactive phytochemical compounds from these medicinal plants have been an intriguing area for many researchers.…”

A Biochemical Approach for Hedysarum candidissimum from Turkey: Screening Phytochemicals, Evaluation of Biological Activites, and Molecular Docking Study

“…[9] Biological activity studies regarding the medicinal plants have revealed that they have a good source of secondary metabolites highly rich in anticarcinogen agents. [9] Thus, the investigations on the plant-based secondary metabolites as well as crude extracts as chemoprevention agent are still an ongoing process.…”