Glassy carbon electrode modified with multi-walled carbon nanotubes sensor for the quantification of antihistamine drug pheniramine in solubilized systems

Jain, Rajeev; Sharma, Sanjay K.

doi:10.1016/j.jpha.2011.09.013

Cited by 41 publications

(19 citation statements)

References 30 publications

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“…Figure 4B highlights the half height peak width of the oxidation peaks and indicates that 5mg/mL provides a balance of peak magnitude and peak sharpness. These two phenomena are related, and are attributed to an increased thickness of the fullerene-MWCNT film which impacts its conductivity, stability and results in increased background currents, as per MWCNT modified electrodes reported in literature (Guo et al 2013;Jain and Sharma 2012). Therefore, 5mg/mL appears to be the optimal load of fullerene-MWCNT that can be cast before these negative characteristics are observed.…”

Section: Enhancing Electroanalytical Sensitivitymentioning

confidence: 90%

Ubiquinone modified printed carbon electrodes for cell culture pH monitoring

McBeth

Dughaishi

Paterson

et al. 2018

Biosensors and Bioelectronics

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The measurement of pH is important throughout many biological systems, but there are limited available technologies to enable its periodical monitoring in the complex, small volume, media often used in cell culture experiments across a range of disciplines. Herein, pad printed electrodes are developed and characterised through modification with: a commercially available fullerene multiwall carbon nanotube composite applied in Nafion, casting of hydrophobic ubiquinone as a pH probe to provide the electrochemical signal, and coated in Polyethylene glycol to reduce fouling and potentially enhance biocompatibility, which together are proven to enable the determination of pH in cell culture media containing serum. The ubiquinone oxidation peak position (E) provided an indirect marker of pH across the applicable range of pH 6-9 (R = 0.9985, n = 15) in complete DMEM. The electrochemical behaviour of these sensors was also proven to be robust; retaining their ability to measure pH in cell culture media supplemented with serum up to 20% (v/v) [encompassing the range commonly employed in cell culture], cycled > 100 times in 10% serum containing media and maintain > 60% functionality after 5 day incubation in a 10% serum containing medium. Overall, this proof of concept research highlights the potential applicability of this, or similar, electrochemical approaches to enable to detection or monitoring of pH in complex cell culture media.

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Section: Enhancing Electroanalytical Sensitivitymentioning

confidence: 90%

Ubiquinone modified printed carbon electrodes for cell culture pH monitoring

McBeth

Dughaishi

Paterson

et al. 2018

Biosensors and Bioelectronics

View full text Add to dashboard Cite

show abstract

“…The best result with respect to signal evaluation and peak shape accompanied by sharper response was obtained 22,23 with BR buffer at pH 9. This supporting electrolyte was chosen for the subsequent experiments.…”

Section: Differential Pulse Voltammetric Studiesmentioning

confidence: 99%

Electrochemical Determination of Anesthetic Drug Ropivacaine in Pharmaceutical Formulations by Differential Pulse Cathodic Adsorptive Stripping Voltammetry

2018

Chem Sci Trans

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Electrochemical behaviour of ropivacaine at glassy carbon electrode was studied by cyclic and differential pulse cathodic adsorptive stripping voltammetry (DPCAdSV) under different experimental conditions. The voltammetric peak current and potential for the reduction of ropivacaine were analyzed at different pH, scan rate and concentration. The voltammograms exhibited irreversible reduction of ropivacaine in B.R. buffer of pH 9. The proposed method was successfully applied for the determination of the drug which is commercial liquid. The proposed differential pulse cathodic adsorptive stripping voltammetric method shows limit of detection (LOD) and limit of quantification (LOQ) are 7.79×10 −7 g/mL and 4.26×10 −7 g/mL respectively.

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“…Detection limit was calculated as LOD = 3 S/m and limit of quantification was calculated using equation LOQ= 10 S/m where, s is the standard deviation of intercept of calibration curve and m is the slope of the related calibration curve [24][25][26] . Low values of detection and quantification limits indicated about the good sensitivity of the proposed method.…”

Section: Limit Of Detection (Lod) and Limit Of Quantificationmentioning

confidence: 99%

Electrochemical Behaviour and Adsorptive Stripping Voltammetric Determination of Cyclophosphamide

2018

Chem Sci Trans

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Electrochemical behaviour of anticancer medication cyclophosphamide was studied in BR buffer of pH 3.0 at glassy carbon electrode using cyclic voltammetry. Cyclophosphamide gave one well defined irreversible reduction peak at potential -1.4V v/s Ag/AgCl reference electrode. The reduction was diffusion controlled and all kinetic parameters were calculated and a reduction mechanism was proposed based on the observed experimental data. Furthermore, differential pulse cathodic adsorptive stripping voltammetry (DPCAdSV) was optimized for determination of cyclophosphamide in bulk form and human urine as biological sample. Good linearity range and obtained LOD and LOQ of 1.1×10 -6 M and 3.67×10 -6 M respectively indicated about the good sensitivity of developed method.

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Glassy carbon electrode modified with multi-walled carbon nanotubes sensor for the quantification of antihistamine drug pheniramine in solubilized systems

Cited by 41 publications

References 30 publications

Ubiquinone modified printed carbon electrodes for cell culture pH monitoring

Ubiquinone modified printed carbon electrodes for cell culture pH monitoring

Electrochemical Determination of Anesthetic Drug Ropivacaine in Pharmaceutical Formulations by Differential Pulse Cathodic Adsorptive Stripping Voltammetry

Electrochemical Behaviour and Adsorptive Stripping Voltammetric Determination of Cyclophosphamide

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