Glia maturation factor-&amp;beta;: a potential therapeutic target in neurodegeneration and neuroinflammation

Fan, Junsheng; Fong, Tszhei; Chen, Xinjie; Chen, Chuyun; Luo, Peng; Xie, Haiting

doi:10.2147/ndt.s157099

Cited by 45 publications

(43 citation statements)

References 80 publications

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“…GMF is considered as a cytokine-responsive protein in erythropoietin-induced and granulocyte-colony stimu-lating factor-induced hematopoietic lineage development (37). It consists of two compounds: glia maturation factor-␤ (GMFB) and GMF-␥, while GMFB may play both protective and detrimental roles in the progression of various neuroinflammatory and neurodegenerative diseases (38). In addition, infusion of GMFB into the cavities of injured nervous tissue stimulated dendritic outgrowth and hypertrophy of specific neurons (38,39).…”

Section: Discussionmentioning

confidence: 99%

“…It consists of two compounds: glia maturation factor-␤ (GMFB) and GMF-␥, while GMFB may play both protective and detrimental roles in the progression of various neuroinflammatory and neurodegenerative diseases (38). In addition, infusion of GMFB into the cavities of injured nervous tissue stimulated dendritic outgrowth and hypertrophy of specific neurons (38,39). NENF is known to be expressed abundantly in the developing brain and spinal cord in embryos, and its neurotrophic activity may provide new insights into the development and maintenance of neurons (40).…”

Section: Discussionmentioning

confidence: 99%

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Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors

Humeník

Cizkova

Číkoš

et al. 2019

Molecular & Cellular Proteomics

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• Canine bone marrow-derived mesenchymal stem (BMMSC) express genes for differentiation toward osteo-, chondro-, and tendo-genic directions. • Canine BMMSC express genes associated with angiogenic, neurotrophic, and immunomodulatory properties. • Dynamic of BMMSC conditioned medium (CM) proteome revealed transcription and translation factors, osteogenic, growth, angiogenic, and neurotrophic factors. • BMMSC CM express angiogenic activity in the chorioallantoic membrane (CAM) assay.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors

Humeník

Cizkova

Číkoš

et al. 2019

Molecular & Cellular Proteomics

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“…BM-MSCs release factors involved in growth and differentiation of neural cells, such as glia maturation factor-β (GMFB) and mesencephalic astrocyte-derived neurotrophic factor (MANF) [ 39 , 40 ]. These cells also release proteins that regulate energy metabolism, such as Me1 (malic enzyme), Aldh1a2, and Aldh1a3 (aldehyde dehydrogenase) [ 41 , 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…These cells also seemed to play a role in metabolism control by releasing dozen of factors, some of them found exclusively in their secretome (Aldh1a3, Aldh1a2, Me1). Of great interest, in BM-MSC secretome includes factors that promote growth and differentiation of glia and neurons, such as glia maturation factor-β (GMFB) and mesencephalic astrocyte-derived neurotrophic factor (MANF) [ 39 , 40 ]. The presence of such factors matches the hypothesized crosstalk between osteogenic and neurogenic niches, which relies on partial overlap of the molecular and secretome profiles as well as on the intimate relationship with vessels [ 54 ].…”

Section: Discussionmentioning

confidence: 99%

A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

et al. 2020

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Background The term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of many organs through paracrine and long-distance signaling. Tissue environment, in both physiological and pathological conditions, may affect the intercellular communication of MSCs. Methods We performed a secretome analysis of MSCs isolated from subcutaneous adipose tissue (sWAT) and visceral adipose tissue (vWAT), and from bone marrow (BM), of normal and obese mice. Results The MSCs isolated from tissues of healthy mice share a common core of released factors: components of cytoskeletal and extracellular structures; regulators of basic cellular functions, such as protein synthesis and degradation; modulators of endoplasmic reticulum stress; and counteracting oxidative stress. It can be hypothesized that MSC secretome beneficially affects target cells by the horizontal transfer of many released factors. Each type of MSC may exert specific signaling functions, which could be determined by looking at the many factors that are exclusively released from every MSC type. The vWAT-MSCs release factors that play a role in detoxification activity in response to toxic substances and drugs. The sWAT-MSC secretome contains proteins involved in in chondrogenesis, osteogenesis, and angiogenesis. Analysis of BM-MSC secretome revealed that these cells exert a signaling function by remodeling extracellular matrix structures, such as those containing glycosaminoglycans. Obesity status profoundly modified the secretome content of MSCs, impairing the above-described activity and promoting the release of inflammatory factors. Conclusion We demonstrated that the content of MSC secretomes depends on tissue microenvironment and that pathological condition may profoundly alter its composition.

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“…Ang (angiogenin), Pgf (placenta growth factor), and Angptl4 (angiopoietin-like 4) could be the key players in angiogenesis of the sWAT-MSC secretome, as evidenced in the Reactome analysis [28][29][30]. Fstl3 BM-MSCs release factors involved in growth and differentiation of neural cells, such as glia maturation factor-β (GMFB) and mesencephalic astrocyte-derived neurotrophic factor (MANF) [39,40]. These cells also release proteins that regulate energy metabolism, such as Me1 (malic enzyme), Aldh1a2, and Aldh1a3 (aldehyde dehydrogenase) [41,42].…”

Section: Reactome Analysis In Samples From Hfd-treated Micementioning

confidence: 99%

A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

Ayaz-Güner

Alessio

Acar

et al. 2020

Preprint

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BackgroundThe term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of many organs through paracrine and long-distance signaling.Tissue environment, in both physiological and pathological conditions, may affect the intercellular communication of MSCs. MethodsWe performed a secretome analysis of MSCs isolated from subcutaneous adipose tissue (sWAT) and visceral adipose tissue (vWAT), and from bone marrow (BM), of normal and obese mice.ResultsThe MSCs isolated from tissues of healthy mice share a common core of released factors: components of cytoskeletal and extracellular structures; regulators of basic cellular functions, such as protein synthesis and degradation; modulators of endoplasmic reticulum stress; and counteracting oxidative stress. It can be hypothesized that MSC secretome beneficially affects target cells by the horizontal transfer of many released factors. Each type of MSC may exert specific signaling functions, which could be determined by looking at the many factors that are exclusively released from every MSC type.The vWAT-MSCs release factors that play a role in detoxification activity in response to toxic substances and drugs. The sWAT-MSC secretome contains proteins involved in in chondrogenesis, osteogenesis, and angiogenesis. Analysis of BM-MSC secretome revealed that these cells exert a signaling function by remodeling extracellular matrix structures, such as those containing glycosaminoglycans. Obesity status profoundly modified the secretome content of MSCs, impairing the above-described activity and promoting the release of inflammatory factors.ConclusionWe demonstrated that the content of MSC secretomes depends on tissue microenvironment and that pathological condition may profoundly alter its composition.

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Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation

Cited by 45 publications

References 80 publications

Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors

Canine Bone Marrow-derived Mesenchymal Stem Cells: Genomics, Proteomics and Functional Analyses of Paracrine Factors

A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

A comparative study on normal and obese mice indicates that the secretome of mesenchymal stromal cells is influenced by tissue environment and physiopathological conditions

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