Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats

Green-Sadan, T.; Kuttner, Y.; Lublin-Tennenbaum, Tammy; Kinor, Noa; Boguslavsky, Yonit; Margel, Shlomo; Yadid, Gal

doi:10.1016/j.expneurol.2005.01.020

Cited by 60 publications

(60 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar stabilization effect was reported previously by us for thrombin, 9,42 glial cell-derived neurotrophic factors (GDNF), 55 Factor VII, 46 and methotrexate 56 conjugated to the γ-Fe 2 O 3 nanoparticles. For a quantitative determination of the effect of free/ conjugated bFGF on the kinetics of the migration of the NOM cells from the MCs aggregates to the magnetic fibrin hydrogel scaffolds, the total number of cells in the fibrin scaffolds was counted using the ImageJ software.…”

supporting

confidence: 67%

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ziv-Polat¹,

Skaat²,

Shahar³

et al. 2012

IJN

View full text Add to dashboard Cite

Novel tissue-engineered magnetic fibrin hydrogel scaffolds were prepared by the interaction of thrombin-conjugated iron oxide magnetic nanoparticles with fibrinogen. In addition, stabilization of basal fibroblast growth factor (bFGF) was achieved by the covalent and physical conjugation of the growth factor to the magnetic nanoparticles. Adult nasal olfactory mucosa (NOM) cells were seeded in the transparent fibrin scaffolds in the absence or presence of the free or conjugated bFGF-iron oxide nanoparticles. The conjugated bFGF enhanced significantly the growth and differentiation of the NOM cells in the fibrin scaffolds, compared to the same or even five times higher concentration of the free bFGF. In the presence of the bFGFconjugated magnetic nanoparticles, the cultured NOM cells proliferated and formed a threedimensional interconnected network composed mainly of tapered bipolar cells. The magnetic properties of these matrices are due to the integration of the thrombin-and bFGF-conjugated magnetic nanoparticles within the scaffolds. The magnetic properties of these scaffolds may be used in future work for various applications, such as magnetic resonance visualization of the scaffolds after implantation and reloading the scaffolds via magnetic forces with bioactive agents, eg, growth factors bound to the iron oxide magnetic nanoparticles.

show abstract

supporting

confidence: 67%

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Ziv-Polat¹,

Skaat²,

Shahar³

et al. 2012

IJN

View full text Add to dashboard Cite

show abstract

“…This observation may be a result of the fact that the immobilization of BAM10 to the nanoparticles increases its stability during the Aβ 40 fibrillation process, and thus prolongs its activity compared with that of the free antibody. A similar stabilization effect was reported previously by us for thrombin, 60 glial cell-derived neurotrophic factor, 61 basic fibroblast growth factor, 62 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), 63 factor VIIa, 64 and methotrexate 65 conjugated to γ-Fe 2 O 3 nanoparticles. Long-term stability of thrombin, TRAIL, and methotrexate conjugated to the γ-Fe 2 O 3 nanoparticles compared with the free ones was also previously demonstrated.…”

supporting

confidence: 64%

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils

Skaat

Corem-Slakmon

Grinberg

et al. 2013

IJN

View full text Add to dashboard Cite

“…Transplantation of simian virus-40 glial cells, which produces and secretes GDNF, or delivery of GDNFconjugated nanoparticles into dorsal and ventral striatum impairs the acquisition of cocaine self-administration in rats (17,18). The upregulation of the GDNF pathway in the midbrain, is the molecular mechanism by which the putative anti-addiction drug ibogaine mediates its desirable action of reducing ethanol consumption (19).…”

Section: Roles Of Gdnf In Drug Dependencementioning

confidence: 99%

The Roles of Glial Cell Line-Derived Neurotrophic Factor, Tumor Necrosis Factor-α, and an Inducer of These Factors in Drug Dependence

et al. 2007

View full text Add to dashboard Cite

Abstract. There are few efficacious medications for drug dependence at present. Recent evidence has suggested that various cytokines are involved in the effects of abused drugs, suggesting that these factors play a role in drug dependence. In this article, the roles of glial cell line-derived neurotrophic factor (GDNF) and tumor necrosis factor-α (TNF-α) in drug dependence are discussed. GDNF inhibits the cocaine-induced upregulation of tyrosine hydroxylase activity in the ventral tegmental area and blocks behavioral responses to cocaine. TNF-α attenuates rewarding effects and locomotor sensitization induced by methamphetamine (METH) and morphine (MOR). Moreover, we mentioned the potential of Leu-Ile, which induces the expression of GDNF and TNF-α, as a novel therapeutic agent for drug dependence. Leu-Ile inhibits not only the development but also the maintenance of METH-or MOR-induced place preference and locomotor sensitization in mice. The inhibitory effect of Leu-Ile on METH-or MOR-induced place preference is not observed in GDNF heterozygous and TNF-α knockout mice. Leu-Ile inhibits METH-or MOR-induced place preference and sensitization by attenuating the METH-or MOR-induced increase in extracellular dopamine levels in the nucleus accumbens via the induction of GDNF and TNF-α expression. These findings suggest that Leu-Ile could be a novel therapeutic agent for drug dependence.

show abstract

Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats

Cited by 60 publications

References 36 publications

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils

The Roles of Glial Cell Line-Derived Neurotrophic Factor, Tumor Necrosis Factor-α, and an Inducer of These Factors in Drug Dependence

Contact Info

Product

Resources

About

Glial cell line-derived neurotrophic factor-conjugated nanoparticles suppress acquisition of cocaine self-administration in rats

Cited by 60 publications

References 36 publications

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Novel magnetic fibrin hydrogel scaffolds containing thrombin and growth factors conjugated iron oxide nanoparticles for tissue engineering

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-&beta; fibrils

The Roles of Glial Cell Line-Derived Neurotrophic Factor, Tumor Necrosis Factor-α, and an Inducer of These Factors in Drug Dependence

Contact Info

Product

Resources

About

Antibody-conjugated, dual-modal, near-infrared fluorescent iron oxide nanoparticles for antiamyloidgenic activity and specific detection of amyloid-β fibrils