Glibenclamide modulates glucantime activity and disposition in Leishmania major

Padrón-Nieves, Maritza; Díaz, E; Machuca, Claudia; Romero, Amarilis; Sucre, Alicia Ponte

doi:10.1016/j.exppara.2008.12.008

Cited by 13 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of chemotherapy for treatment of leishmaniasis and other infectious diseases has been addressed in latter years 7,9,14,[21][22][23]26,30,32,34 . Recently, we showed that HBO is toxic for L. amazonensis promastigotes and can reduce macrophage susceptibility to infection and the size of footpad lesion in BALB/c mice 2,3 .…”

Section: Discussionmentioning

confidence: 99%

“…Various compounds have been tested, combined with glucantime, in order to improve chemotherapy 7,9,14,[21][22][23]26,28,30,34 , and the rationale behind combining drugs and therapies allows the reduction of treatment duration, resulting in fewer side effects and fewer delays in the development of resistance 8,34 . This report describes the effect of the combined therapy of HBO and glucantime against intracellular amastigotes in vitro and against infection in mouse model BALB/c.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

Ayres

Fedele

Marcucci

et al. 2011

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

SUMMARYIn this study we investigated the efficacy of hyperbaric oxygen (HBO) therapy, alone or combined with the pentavalent antimonial glucantime on Leishmania amazonensis infection. In parallel, the effect of Brazilian red propolis gel (propain) alone or combined with glucantime on L. amazonensis infection was evaluated. The inhibition of the infection in macrophages treated with glucantime in combination with HBO exposition was greater than that of macrophages treated with glucantime alone or HBO alone. The susceptible mouse strain BALB/c infected in the shaved rump with L. amazonensis treated with glucantime and exposed to HBO showed: time points in the course of the disease in which lesions were smaller than those of mice treated with glucantime alone and revascularization of the skin in the lesion site; interferon-gamma (IFN-γ) levels were not elevated in lymph node cells from these animals. Propain alone was not efficient against lesions, although less exudative lesions were observed in animals treated with propain alone or combined with glucantime. These results reveal the potential value of HBO and red propolis in combination with glucantime for treating cutaneous leishmaniasis and encourage further studies on the effect of more aggressive HBO, propolis and glucantime therapies on different mouse models of leishmaniasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

Ayres

Fedele

Marcucci

et al. 2011

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

show abstract

“…As understanding increases, the opportunity for therapeutic intervention may become apparent. The antidiabetic glyburide [91] clearly has potential in treating melioidosis given the findings from patients who are on the drug, and it has shown (in combination with glucantime) to have some activity against Leishmania major, another intracellular pathogen where IFN-γ production is critical for host defense [91,92].…”

Section: Therapeutics To Rebalance the Cytokine Networkmentioning

confidence: 99%

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

Laws

Taylor

Russell

et al. 2019

Expert Review of Anti-infective Therapy

View full text Add to dashboard Cite

Introduction: Melioidosis is a significant health problem within endemic areas such as Southeast Asia and Northern Australia. The varied presentation of melioidosis and the intrinsic antibiotic resistance of Burkholderia pseudomallei, the causative organism, make melioidosis a difficult infection to manage. Often prolonged courses of antibiotic treatments are required with no guarantee of clinical success. Areas covered: B. pseudomallei is able to enter phagocytic cells, affect immune function, and replicate, via manipulation of the caspase system. An examination of this mechanism, and a look at other factors in the pathogenesis of melioidosis, shows that there are multiple potential points of therapeutic intervention, some of which may be complementary. These include the directed use of antimicrobial compounds, blocking virulence mechanisms, balancing or modulating cytokine responses, and ameliorating sepsis. Expert commentary: There may be therapeutic options derived from drugs in clinical use for unrelated conditions that may have benefit in melioidosis. Key compounds of interest primarily affect the disequilibrium of the cytokine response, and further preclinical work is needed to explore the utility of this approach and encourage the clinical research needed to bring these into beneficial use.

show abstract

“…For cutaneous leishmaniasis, the recommendation is a 10-20 mg Sb/kg of body weight/day dose until the lesions heal. For mucocutaneous leishmaniasis, it is recommended the administration of 20 mg Sb/kg of body weight/day for 30 days [6,7,8]. The use of a natural product, three phenylpropanoid dimers (1-3), has been recently reported as an active substance for the treatment of leishmaniasis [9].…”

Section: Introductionmentioning

confidence: 99%

Use of Pseudoboehmite Nanoparticles for Drug Delivery System of Glucantime®

Munhoz

Martins

Ribeiro

et al. 2016

JNanoR

View full text Add to dashboard Cite

Recently, the incidence of American Cutaneous Leishmaniasis (ACL) has been grown in Latin America, especially in Brazil, where from 1980 to 2005, 605,062 cases were recorded. The drug glucantime®, whose active principle is the meglumine antimoniate (or meglumine antimonate) is used in the treatment of leishmaniasis. Its toxicity is due mainly to the presence of antimony in its structure. Therefore, it is crucial to determine the safe dose levels of this drug in the treatment. Drug delivery systems have been currently the focus of many studies due to its effectiveness in treating diseases proved to be superior compared to conventional methods. Drug delivery systems can avoid overdosing by decreasing the amount of drug intake, which results in a better therapeutic effect in addition to reducing the risks of plasma concentration reaching toxic levels. Synthetic nanomaterials have been receiving great attention due to their potential applications in pharmaceutical technology as well as the possibility of controlling their particle size and composition, which allows a better performance in drug release. Pseudoboehmite is a synthetic aluminum compound precursor of alumina [1] and a polymorph of boehmite, with active groups in its structure [2], making it an excellent adsorbent material. In this work, pseudoboehmite was prepared by using the sol-gel process for being used as an excipient. The incorporation of pseudoboehmite in glucantime® was performed in the processing of tablets. Both pseudoboehmite and the tablets were characterized via X-ray diffraction (XRD), differential thermal analysis (DTA), thermogravimetric analysis (TG), and scanning electron microscopy (SEM) using secondary electron detector and EDS detector. The release profile was obtained by UV/Vis spectroscopy for in vitro simulation. No reaction between the drug and the excipient was observed.

show abstract

Glibenclamide modulates glucantime activity and disposition in Leishmania major

Cited by 13 publications

References 42 publications

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

Potential utility of hyperbaric oxygen therapy and propolis in enhancing the leishmanicidal activity of glucantime

The treatment of melioidosis: is there a role for repurposed drugs? A proposal and review

Use of Pseudoboehmite Nanoparticles for Drug Delivery System of Glucantime®

Contact Info

Product

Resources

About