Gliclazide‐induced hepatitis

Abstract

A 64-year-old man presented with tiredness, and a diagnosis of type 2 diabetes was made based on two raised random blood glucose values. He was commenced on gliclazide. Three months later, blood investigations revealed elevated liver enzymes (hepatitic pattern). Further investigations revealed no obvious cause for his abnormal liver function tests. Gliclazide was discontinued and a subsequent liver biopsy revealed features consistent with an acute hepatitis. His liver function tests returned to normal three months after discontinuation of gliclazide.

Type 2 Diabetes in Children is Frequently Associated with Elevated Alanine Aminotransferase

“…The current prevalence of NASH in adult T2DM is unclear (23), and the prevalence of any form of NAFLD in children with T2DM is unknown (24). Further increasing the importance of better a understanding NAFLD in this population is the fact that medications currently used in T2DM may possibly be hepatotoxic.…”