Glioblastoma multiforme after microsurgery for acoustic neuroma without radiotherapy: Limitations of the Cahan criteria

Hoa, Michael; Rhiew, Richard; Kupsky, William J.; Guthikonda, Murali; Monsell, Edwin M.

doi:10.1016/j.otohns.2008.03.025

Cited by 13 publications

(3 citation statements)

References 4 publications

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“…In a recent review the risk of developing an SRS-induced neoplasm is approximately 0.04 % at 15 years [18]. We might argue that the apparent association of radiosurgery with GBM formation may simply reflect the statistical intersection of the frequent use of this therapeutic modality with the not so uncommon development of a GBM, as Hoa et al [9] also reported the association of a cerebellar GBM 2 years after microsurgery for vestibular schwannoma in the same side, without radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma after AVM radiosurgery. Case report and review of the literature

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Glioblastoma after AVM radiosurgery. Case report and review of the literature

et al. 2015

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“…8,27,28 Meeting these criteria, however, does not determine causality and does not exclude the possibility of coincidental secondary lesions. 29 There are multiple reports of post-radiation UHGPS, both intracranially and otherwise, following conventional radiotherapy, but no reports in the literature following SRS. 6,30 In the present case, isodose curve analysis showed the UHGPS to be enveloped by the radiation field, and a period of 7.5 years had elapsed from the initial radiation treatment to the tissue diagnosis of pleomorphic sarcoma, satisfying two of Cahan's criteria.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Sarcoma in a Large Vestibular Schwannoma Following Stereotactic Radiosurgery: Case Report

Schmitt¹,

Carlson²,

Giannini³

et al. 2011

Neurosurgery

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This is the first report of undifferentiated high-grade pleomorphic sarcoma (formerly called malignant fibrous histiocytoma) following SRS. This case demonstrates the difficulty of establishing malignant degeneration of a neoplasm following SRS without pretreatment tissue diagnosis. Patients with presumed benign tumors should be counseled about the rare risk of malignant transformation prior to undertaking SRS.

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“…The reports of secondary malignancy after SRS may represent the numerator but the denominator is still unknown. Hoa et al [36] described a 58-year-old female who developed a glioblastoma multiforme in the area of a previous vestibular schwannoma that was resected 2 years prior to presentation. She had not received any treatment for her vestibular schwannoma other than microsurgery.…”

Section: Discussionmentioning

confidence: 99%

The Risk of Malignancy Anywhere in the Body after Linear Accelerator (LINAC) Stereotactic Radiosurgery

Rahman¹,

Neal²,

Baruch³

et al. 2014

Stereotact Funct Neurosurg

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Background: Despite the conformity of stereotactic radiosurgery (SRS) treatment, there are concerns about the risk of malignancy. Objective: We compared the number of cancer cases observed after treatment in a group of SRS patients to the number of cancer cases that would be expected in an age- and gender-matched group. Methods: We collected data from the University of Florida SRS database for patients treated for meningiomas, intracranial schwannomas, arteriovenous malformations (AVMs), trigeminal neuralgia, pituitary adenomas, cavernous angiomas, and metastases. We used the Florida Cancer Data System (FCDS) to determine the actual cancer rates for SRS-treated patients, and we compared these to the cancer rates in similar groups of non-SRS-treated patients based on rates available from the SEER (surveillance epidemiology and end results) database. Results: A total of 2,369 patients were analyzed. Of these, 862 were patients with metastases who were analyzed only to ensure the sensitivity of using the FCDS to determine malignancy rates. The results for patients with more than 5 years of follow-up are reported. Without the metastases patients, a total of 627 patients had more than 5 years of follow-up data. Follow-up in patient-years was 1,711 for the meningioma patients, 1,851 for the schwannoma patients, 1,407 for the AVM patients and 338 for patients with a diagnosis of ‘other'. The observed cancer rate in the meningioma patients was 3.96% compared to the expected rate of 10% (binomial 95% confidence interval, CI = 1.85-7.94). The observed cancer rate in the schwannoma patients was 4.93% compared to the expected rate of 12.5% (95% CI = 2.61-8.89). The observed cancer rate in the AVM patients was 3.64% compared to the expected rate of 4.43% (95% CI = 1.49-8.10). The observed cancer rate in patients treated for other diagnoses (e.g. pituitary adenoma or trigeminal neuralgia) was 0% compared to the expected rate of 6.36% (95% CI = 0-11.7). Conclusions: In a large population of SRS-treated patients, there was no increased risk of malignancy compared to the general population.

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Glioblastoma multiforme after microsurgery for acoustic neuroma without radiotherapy: Limitations of the Cahan criteria

Cited by 13 publications

References 4 publications

Glioblastoma after AVM radiosurgery. Case report and review of the literature

Glioblastoma after AVM radiosurgery. Case report and review of the literature

Radiation-Induced Sarcoma in a Large Vestibular Schwannoma Following Stereotactic Radiosurgery: Case Report

The Risk of Malignancy Anywhere in the Body after Linear Accelerator (LINAC) Stereotactic Radiosurgery

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