Glioma Risks Associate With Genetic Polymorphisms of <i>XRCC1</i> Gene in Chinese Population

Feng, Xingjun; Miao, Guozhuan; Han, Yipeng; Xu, Yong; Wu, Huayun

doi:10.1002/jcb.24753

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…Previous studies have reported that XRCC1 gene polymorphisms contribute to the development of cancers, such as lung, colorectal, breast, and ovarian cancers (Guo et al, 2015;Malisic et al, 2015;Nissar et al, 2015;Wang et al, 2015b). Recently, several epidemiologic studies have assessed the association between XRCC1 gene polymorphisms and susceptibility to glioma, but their findings are inconclusive (Feng et al, 2014;Li et al, 2014;Rodriguez-Hernandez et al, 2014;Wang et al, 2015a). In our study, we examined a Chinese Han population and investigated the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk for susceptibility to gliomas.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population

Fan¹,

Zhou

Yin³

2016

Genet. Mol. Res.

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ABSTRACT. We conducted a study in a Chinese Han population to investigate the role of XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) with a risk of susceptibility to gliomas. Samples from 115 patients with gliomas and 228 control subjects were consecutively collected between March 2012 and December 2014. Genotype analysis of XRCC1 Arg399Gln and Arg194Trp was performed using polymerase chain reaction-restriction fragment length polymorphism assay. All the analyses were performed using the SPSS 17.0 software package. We observed that the XRCC1 Arg399Gln and Arg194Trp genotype frequencies conformed to the Hardy-Weinberg equilibrium. We observed that the Trp/Trp genotype of XRCC1 Arg194Trp was associated with an increased risk of glioma when compared to the wild-type genotype (odds ratio (OR) = 2.14, 95% confidence interval (CI) = 1.14-3.86, P = 0.03). In the dominant model, we found that the Arg/Trp + Trp/Trp genotype of XRCC1 Arg194Trp could significantly elevate the susceptibility of developing glioma (OR = 1.79, 95%CI = 1.07-0.94). However, we observed that the XRCC1 Arg399Gln genetic polymorphism did not influence the risk of glioma. In summary, we suggest that the XRCC1 Arg194Trp genetic polymorphism could be a predictive biomarker for the susceptibility to glioma in a Chinese population.

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Section: Introductionmentioning

confidence: 99%

Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population

Fan¹,

Zhou

Yin³

2016

Genet. Mol. Res.

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“…Gliomas may be caused by both intrinsic and environmental factors. Recently, a vast number of studies have shown that genetic factors such as single nucleotide polymorphisms (SNPs) play an important role in modifying glioma susceptibility (Feng et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

CXCL12 G801A polymorphism and susceptibility to glioma: a case‑control study

Chang

Yang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Previous studies have demonstrated that the CXCL12 G801A polymorphism is closely correlated with tumor susceptibility. In addition, the CXCL12/CXCR4 pathway is closely related to proliferation, metastasis, and invasion of glioma. However, the genetic effects of the CXCL12 G801A polymorphism on glioma risk in Chinese populations remain unknown. In this study, we investigated the potential associations between the CXCL12 G801A polymorphism with glioma susceptibility and its clinicopathological characteristics. Frequencies of CXCL12 G801A polymorphic variants between glioma patients (N = 750) and healthy controls (N = 750) were assessed using restriction length fragment polymorphism analysis. The association among the CXCL12 G801A polymorphism, glioma grade (WHO classification), and histological type was also evaluated. Our results showed that patients with glioma had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.039) as compared with healthy controls. When stratified by the glioma histology, high-grade glioma patients had significantly higher frequency of the CXCL12-3' A/A genotypes (P = 0.019) as compared with low-grade glioma patients. When stratified by the WHO grade, significantly higher frequency of the CXCL12-3' A/A genotype was observed in stage IV glioma patients (P = 0.037). We conclude that the CXCL12 G801A polymorphism is a risk factor that increases susceptibility to gliomas in a subset of the general Han Chinese population.

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“…Over 300 single nucleotide polymorphisms (SNPs) have been identified in XRCC1 (http://www.ncbi.nlm.nih.gov/ projects/SNP), and previous studies have also reported that a number of SNPs in DNA repair genes may modify glioma risk [9][10][11][12][13][14]. The most extensively studied has been rs25487 in codon 399 of exon 10, a non-synonymous G/A polymorphism changing arginine to glutamine.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, some case-control studies and meta-analysis were carried out [10,[12][13][14][15][16][17]. However, the cumulative results are still inconclusive due to different ethnicities, research samples, ages and subtypes of glioma.…”

Section: Introductionmentioning

confidence: 99%

Association between XRCC1 polymorphisms and glioma risk among Chinese population

Jiang¹,

Qu²,

Qu³

et al. 2014

Med Oncol

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The pathogenesis of glioma remains largely unknown now. It has been suggested that the X-ray cross-complementing group 1 (XRCC1) gene may influence the capacity to repair DNA damage leading to an increased gliomas susceptibility. This study aimed to evaluate the relationship between XRCC1 polymorphisms and glioma risk. Genotypes were assessed in 368 Chinese glioma patients and 346 healthy controls. XRCC1 Arg194Trp (rs1799782), Arg280His (rs25489) and Arg399Gln (rs25487) and three additional polymorphisms were directly sequenced. The frequency of Arg280His A allele was significant lower in glioma group than in healthy controls [9.6 vs 16%, OR=0.60 (0.46-0.80), P<0.001]; the frequencies of GA or AA genotypes were different in two groups (16.6 vs 22.8%, 1.3 vs 4.7%). The frequency of Arg399Gln A allele was significant higher in glioma group than in healthy controls [38.7 vs 30.1%, OR=1.29 (1.11-1.49), P=0.001]; the frequencies of GA or AA genotypes were different in two groups (45.4 vs 38.2%, 16 vs 10.9%). This study demonstrates that the rs25489 (Arg280His) and Arg399Gln (rs25487) polymorphisms in XRCC1 gene might influence the risk of developing glioma in Chinese population.

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Glioma Risks Associate With Genetic Polymorphisms of XRCC1 Gene in Chinese Population

Cited by 6 publications

References 32 publications

Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population

Investigation of the role of XRCC1 genetic polymorphisms in the development of gliomas in a Chinese population

CXCL12 G801A polymorphism and susceptibility to glioma: a case‑control study

Association between XRCC1 polymorphisms and glioma risk among Chinese population

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