Global Allergy Forum and 3rd Davos Declaration 2015

Bieber, Thomas; Akdiş, Cezmi A.; Lauener, Roger; Traidl‐Hoffmann, Claudia; Schmid‐Grendelmeier, Peter; Schäppi, Georg; Allam, Jean‐Pierre; Apfelbacher, Christian; Augustin, M.; Beck, Lisa A.; Biedermann, Tilo; Braun-Fahrländer, C; Chew, Fook Tim; Clavel, Thomas; Crameri, Reto; Darsow, Ulf; Deleuran, Mette; Dittlein, Daniela; Duchna, Hans‐Werner; Eichenfeld, Lawrece F; Eyerich, Kilian; Frei, Remo; Gelmetti, Carlo; Gieler, Uwe; Gilles, Stefanie; Glatz, Martin; Grando, Karin; Green, J.; Gutermuth, Jan; Guttman‐Yassky, Emma; Hanifin, Jon M.; Hijnen, DirkJan; Hoetzenecker, Wolfram; Irvine, Alan D.; Kalweit, A.; Katoh, Norito; Knol, Edward F.; Koren, Hillel S.; Möhrenschlager, Matthias; Münch, Daniela; Novak, Natalija; O’Mahony, Liam; Paller, Amy S.; Rhyner, Claudio; Roduit, Caroline; Schiesser, K.; Schröder, Jens‐Michael; Simon, Dagmar; Simon, Hans‐Uwe; Sokołowska, Milena; Spuls, Phyllis I.; Stalder, J.F.; Straub, Diane M.; Szalai, Zsuzsanna; Taı̈eb, Alain; Takaoka, Roberto; Todd, Gail; Todorova, Antonia; Vestergaard, Christian; Werfel, Thomas; Wollenberg, Andreas; Ring, Johannes

doi:10.1111/all.12857

Cited by 52 publications

(15 citation statements)

References 37 publications

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“…Currently, there is no recommendation to use pre- or probiotics for treatment or prevention of asthma. Nevertheless, there is accumulating evidence that antenatal interactions between maternal diet, gut bacteria and bacterial metabolites may lead to immunological imprinting on the developing fetal immune system that could influence the development of allergy and asthma later in life [ 89 ]. Thus, further studies are required to determine if appropriate prebiotic and probiotic use during pregnancy may functionally impact the maternal gut microbiome with subsequent effects on maternal immune function and risk of asthma in the offspring [ 90 ].…”

Section: Introductionmentioning

confidence: 99%

Microbiome and asthma

Sokołowska

Frei

Lunjani

et al. 2018

asthma res and pract

133

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The mucosal immune system is in constant communication with the vast diversity of microbes present on body surfaces. The discovery of novel molecular mechanisms, which mediate host-microbe communication, have highlighted the important roles played by microbes in influencing mucosal immune responses. Dendritic cells, epithelial cells, ILCs, T regulatory cells, effector lymphocytes, NKT cells and B cells can all be influenced by the microbiome. Many of the mechanisms being described are bacterial strain- or metabolite-specific. Microbial dysbiosis in the gut and the lung is increasingly being associated with the incidence and severity of asthma. More accurate endotyping of patients with asthma may be assisted by further analysis of the composition and metabolic activity of an individual’s microbiome. In addition, the efficacy of specific therapeutics may be influenced by the microbiome and novel bacterial-based therapeutics should be considered in future clinical studies.

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Section: Introductionmentioning

confidence: 99%

Microbiome and asthma

Sokołowska

Frei

Lunjani

et al. 2018

asthma res and pract

133

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“…Allergic diseases in industrialized countries, including asthma, have increased in incidence and severity1234. This is partially attributed to the increased concentration of air pollutants and aeroallergens (pollen and fungal spores)15.…”

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confidence: 99%

Estimating the abundance of airborne pollen and fungal spores at variable elevations using an aircraft: how high can they fly?

Damialis

Kaimakamis

Konoglou

et al. 2017

Sci Rep

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Airborne pollen and fungal spores are monitored mainly in highly populated, urban environments, for allergy prevention purposes. However, their sources can frequently be located outside cities’ fringes with more vegetation. So as to shed light to this paradox, we investigated the diversity and abundance of airborne pollen and fungal spores at various environmental regimes. We monitored pollen and spores using an aircraft and a car, at elevations from sea level to 2,000 m above ground, in the region of Thesssaloniki, Greece. We found a total of 24 pollen types and more than 15 spore types. Pollen and spores were detected throughout the elevational transect. Lower elevations exhibited higher pollen concentrations in only half of plant taxa and higher fungal spore concentrations in only Ustilago. Pinaceae and Quercus pollen were the most abundant recorded by airplane (>54% of the total). Poaceae pollen were the most abundant via car measurements (>77% of the total). Cladosporium and Alternaria spores were the most abundant in all cases (aircraft: >69% and >17%, car: >45% and >27%, respectively). We conclude that pollen and fungal spores can be diverse and abundant even outside the main source area, evidently because of long-distance transport incidents.

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“…This shows on the one hand that a high degree of relatedness exists between allergy spectrum diseases. On the other hand, asthma and atopic eczema are each by themselves highly heterogeneous diseases, different clinical phenotypes of which are commonly referred to as “endotypes” . The exact definition of endotypes, and the role of allergic sensitization in defining these endotypes, remains a matter of scientific debate.…”

Section: Atopy: the Role Of Genetic Predispositionmentioning

confidence: 99%

The role of environmental factors in allergy: A critical reappraisal

Gilles

Akdiş

Lauener

et al. 2018

Experimental Dermatology

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Allergies are usually referred to as type I hypersensitivity reactions against innocuous environmental antigens, characterized by a Th2/IgE-dominated inflammation. They can manifest themselves in various organs, such as skin, gastrointestinal and respiratory tract, and comprise diseases as diverse as allergic rhinitis and conjunctivitis, bronchial asthma, oral allergy syndrome, food allergy, urticaria and atopic eczema, but also anaphylactic shock. Within the last decades, there was a significant global increase in allergy prevalence, which has been mostly attributed to changes in environment and lifestyle. But which, among all factors discussed, are the most relevant, and what are the mechanisms by which these factors promote or prevent the development of allergic diseases? To answer this, it is necessary to go back to the two key questions that have occupied allergy researchers for the last decades: Firstly, what makes an allergen an allergen? Secondly, why are more and more individuals affected? Within the last decade, we have made considerable progress in answering these questions. This review gives an overview over scientific progress in the field, summarizes latest findings and points out future prospective and research needs.

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Global Allergy Forum and 3rd Davos Declaration 2015

Cited by 52 publications

References 37 publications

Microbiome and asthma

Microbiome and asthma

Estimating the abundance of airborne pollen and fungal spores at variable elevations using an aircraft: how high can they fly?

The role of environmental factors in allergy: A critical reappraisal

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