2006
DOI: 10.1093/carcin/bgi377
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Global alterations in mRNA polysomal recruitment in a cell model of colorectal cancer progression to metastasis

Abstract: Tumour onset and progression are due to the accumulation of genomic lesions, which alter gene expression and ultimately proteome activities. These lesions are thought to affect primarily the transcriptional control of gene expression. In the present study, we aimed at evaluating the genome-wide occurrence of alterations in the translational control exploiting an isogenic, phenotypically validated cellular model of colorectal cancer (CRC) transition from invasive carcinoma to metastasis. In this model, microarr… Show more

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Cited by 107 publications
(121 citation statements)
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“…3). Indeed, enhanced growth of the SW620 clone compared with the SW480 clone in both culture and agar was previously shown (29,30). These data suggest that O-GlcNAcylation enhances anchorage-independent growth, an assumption supported by a previous report showing that colony formation by lung and colon cancer cells was reduced by OGT silencing and increased by OGA inhibition (10).…”
Section: Discussionsupporting
confidence: 76%
“…3). Indeed, enhanced growth of the SW620 clone compared with the SW480 clone in both culture and agar was previously shown (29,30). These data suggest that O-GlcNAcylation enhances anchorage-independent growth, an assumption supported by a previous report showing that colony formation by lung and colon cancer cells was reduced by OGT silencing and increased by OGA inhibition (10).…”
Section: Discussionsupporting
confidence: 76%
“…A recent comparison of a colon cancer cell line (SW480) and its metastatic variant (SW620) analyzing total and polysomal RNA changes also came to the conclusion that translational alterations were more extensive that transcriptional alterations in mediating metastatic changes in this system (Provenzani et al, 2006). The mRNAs showing changes in polysome distribution in this analysis possessed longer 5…”
Section: Inherited Cancer Predisposition Syndromes Implicating Mtorc1mentioning
confidence: 75%
“…6 An unexpected complexity in the modulation of the fate of mRNAs along with a widespread alteration of that process in cancer cells was found in recent studies. [7][8][9] The synthesis of the p53 protein itself has been shown to be modulated by miR-125b 10 or by RPL26 and nucleolin, that produce opposite effects on the rate of p53 mRNA translation. 11 Moreover, p53 target genes, including CDKN1A (p21), BBC3 (PUMA) and BAX, can be regulated post-transcriptionally by miRNAs or RBPs, some of which can be direct p53 target genes.…”
mentioning
confidence: 99%