Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders: a sulcal pits analysis

Lefrere, Antoine; Auzias, Guillaume; Favre, Pauline; Kaltenmark, Irène; Houenou, Josselin; Piguet, Camille; Polosan, Mircea; Eyler, Lisa T.; Phillips, Mary L.; Versace, Amelia; Wessa, Michelle; McDonald, Colm; Cannon, Dara M.; Brambilla, Paolo; Deruelle, Christine; Belzeaux, Raoul

doi:10.1016/j.jad.2022.12.156

Cited by 6 publications

(4 citation statements)

References 42 publications

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“…In particular, the identification and localization (by providing the stereotactic coordinates) of sulcal pits, that is, the deepest local points of sulcal fundi, is straightforward with our approach as the sulcal pits simply become the highest local points of an examined sulcus. The sulcal pits are important anatomical features closely related to human brain function (Im & Grant, 2019) and valuable markers to distinguish atypical from typical patterns of development by means of sulcal pit‐based analyses, as has been demonstrated in autism spectrum disorder (Brun et al, 2016), dyslexia (Im et al, 2016), attention‐deficit/hyperactivity disorder (Li et al, 2021), and bipolar disorders (Lefrere et al, 2023).…”

Section: Resultsmentioning

confidence: 99%

“…The cerebral sulci and gyri are fundamental in cortical anatomy as well as neuroimage processing and analysis. Sulcal‐related neuroimage processing and analysis are employed, among others, in brain registration (Thompson & Toga, 1996), examination of healthy brain variations (Mangin et al, 2004), investigation of discrepancies between normal and diseased brains (Ashburner et al, 2003), age‐related studies (Kochunov et al, 2005), gyro‐sulcal functional difference studies (Wang et al, 2023), morphometry (Yun et al, 2013), and especially cortical folding analysis that may provide insight into the biological underpinnings of diseases (Lefrere et al, 2023), such as a reduced sulcal depth in depression (Shin et al, 2022) and a decreased number of sulcal pits in attention‐deficit/hyperactivity disorder (Li et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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On presentation of the human cerebral sulci from inside of the cerebrum

Nowinski¹

2023

Journal of Anatomy

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The human cerebral cortex is highly convoluted forming patterns of gyri separated by sulci. The cerebral sulci and gyri are fundamental in cortical anatomy as well as neuroimage processing and analysis. Narrow and deep cerebral sulci are not fully discernible either on the cortical or white matter surface. To cope with this limitation, I propose a new sulci presentation method that employs the inner cortical surface for sulci examination from the inside of the cerebrum. The method has four steps, construct the cortical surface, segment and label the sulci, dissect (open) the cortical surface, and explore the fully exposed sulci from the inside. The inside sulcal maps are created for the left and right lateral, left and right medial, and basal hemispheric surfaces with the sulci parcellated by color and labeled. These three‐dimensional sulcal maps presented here are probably the first of this kind created. The proposed method demonstrates the full course and depths of sulci, including narrow, deep, and/or convoluted sulci, which has an educational value and facilitates their quantification. In particular, it provides a straightforward identification of sulcal pits which are valuable markers in studying neurologic disorders. It enhances the visibility of sulci variations by exposing branches, segments, and inter‐sulcal continuity. The inside view also clearly demonstrates the sulcal wall skewness along with its variability and enables its assessment. Lastly, this method exposes the sulcal 3‐hinges introduced here.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

On presentation of the human cerebral sulci from inside of the cerebrum

Nowinski¹

2023

Journal of Anatomy

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“…This suggests that a critical period around the 23 weeks of gestation could exist, which corresponds to the establishment of the STS. A study based on sulcal pit analyses demonstrated a specific cortical morphology in bipolar patients with a neurodevelopmental phenotype [50] . They exhibited a higher number of sulcal pits compared to bipolar patients without this neurodevelopmental aspect.…”

Section: Discussionmentioning

confidence: 99%

Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations

Lerosier,

Simon,

Takerkart

et al. 2024

AIMSN

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<abstract> <p>Auditory verbal hallucinations (AVHs) are among the most common and disabling symptoms of schizophrenia. They involve the superior temporal sulcus (STS), which is associated with language processing; specific STS patterns may reflect vulnerability to auditory hallucinations in schizophrenia. STS sulcal pits are the deepest points of the folds in this region and were investigated here as an anatomical landmark of AVHs. This study included 53 patients diagnosed with schizophrenia and past or present AVHs, as well as 100 healthy control volunteers. All participants underwent a 3-T magnetic resonance imaging T1 brain scan, and sulcal pit differences were compared between the two groups. Compared with controls, patients with AVHs had a significantly different distributions for the number of sulcal pits in the left STS, indicating a less complex morphological pattern. The association of STS sulcal morphology with AVH suggests an early neurodevelopmental process in the pathophysiology of schizophrenia with AVHs.</p> </abstract>

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“…Further interpretation of these group statistics fall beyond the scope of the current methodological work, but we refer readers interested in such statistical analysis at the scale of sulcal basins to e.g. [16] where the authors reported an experiment on the asymmetry across left and right hemispheres, [80] for a statistical analysis of the relationship between basins frequency and IQ, or [81][82][83] for applications to psychiatric disorders. Note that a strong influence of the sulcal basins matching technique on the resulting statistics as we observed in Fig 8 is expected for all these publications.…”

Section: Plos Onementioning

confidence: 99%

Population-wise labeling of sulcal graphs using multi-graph matching

Yadav,

Dupé,

Takerkart

et al. 2023

PLoS ONE

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Population-wise matching of the cortical folds is necessary to compute statistics, a required step for e.g. identifying biomarkers of neurological or psychiatric disorders. The difficulty arises from the massive inter-individual variations in the morphology and spatial organization of the folds. The task is challenging both methodologically and conceptually. In the widely used registration-based techniques, these variations are considered as noise and the matching of folds is only implicit. Alternative approaches are based on the extraction and explicit identification of the cortical folds. In particular, representing cortical folding patterns as graphs of sulcal basins—termed sulcal graphs—enables to formalize the task as a graph-matching problem. In this paper, we propose to address the problem of sulcal graph matching directly at the population level using multi-graph matching techniques. First, we motivate the relevance of the multi-graph matching framework in this context. We then present a procedure for generating populations of artificial sulcal graphs, which allows us to benchmark several state-of-the-art multi-graph matching methods. Our results on both artificial and real data demonstrate the effectiveness of multi-graph matching techniques in obtaining a population-wise consistent labeling of cortical folds at the sulcal basin level.

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Global and local cortical folding alterations are associated with neurodevelopmental subtype in bipolar disorders: a sulcal pits analysis

Cited by 6 publications

References 42 publications

On presentation of the human cerebral sulci from inside of the cerebrum

On presentation of the human cerebral sulci from inside of the cerebrum

Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations

Population-wise labeling of sulcal graphs using multi-graph matching

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