Global approaches for global challenges: The possible support of rehabilitation in the management of COVID‐19

Coraci, Daniele; Fusco, Augusto; Frizziero, Antonio; Giovannini, Silvia; Biscotti, Lorenzo; Padua, Luca

doi:10.1002/jmv.25829

Cited by 34 publications

(39 citation statements)

References 10 publications

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“…This leads to a reduction in muscle strength, which causes poor sputum expulsion and significantly increases the risk of deep vein thrombosis. 6 Patients in the ICU can have several complications owing to extended immobilization and many hours in the prone position; 7 , 23 , 24 these include neuromuscular complications, severe muscle weakness and fatigue, joint stiffness, dysphagia, psychological problems, reduced mobility, severely impaired quality of life, frequent falls, and even quadriparesis. 13 , 19 In addition, persistent mental health impairment is commonly described following treatment in the ICU, with pooled estimates showing a high prevalence of depression (29%).…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation of patients post-COVID-19 infection: a literature review

et al. 2020

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Rehabilitation is important for patients with coronavirus disease 2019 (COVID-19) infection. Given the lack of guidelines in English on the rehabilitation of these patients, we conducted a review of the most recent reports. We performed this literature review using the principal research databases and included randomized trials, recommendations, quasi-randomized or prospective controlled clinical trials, reports, guidelines, field updates, and letters to the editor. We identified 107 studies in the database search, among which 85 were excluded after screening the full text or abstract. In total, 22 studies were finally included. The complexity of the clinical setting and the speed of spread of the severe acute respiratory syndrome coronavirus 2, which leads to rapid occupation of beds in the intensive care unit, make it necessary to discharge patients with COVID-19 who have mild symptoms as soon as possible. For these reasons, it is necessary to formulate rehabilitation programs for these patients, to help them restore physical and respiratory function and to reduce anxiety and depression, particularly patients with comorbidities and those who live alone or in rural settings, to restore a good quality of life.

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Section: Discussionmentioning

confidence: 99%

Rehabilitation of patients post-COVID-19 infection: a literature review

et al. 2020

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“…Hence, therapeutics aimed at reducing the severity and duration of symptoms are of critical importance in preventing sustained injury. Many have emphasized the urgent need to gain a clearer understanding of the damage and develop drugs to facilitate the restoration of these organs [ 271 ]. Since the SARS-CoV-2 only emerged little more than a few months ago, little is known at present about whether the virus may elevate the risk of developing disorders in later life, such as cancer, neurodegenerative diseases, cardiovascular disorders, stroke, hypertension, and so on.…”

Section: How Might Ergothioneine Be Beneficial In Alleviating Covimentioning

confidence: 99%

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Cheah

Halliwell

2020

Antioxidants

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Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.

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“…Coraci et al 2 have commented on the significance of the treatment options suggested by us. However, the treatment options have not been incorporated in the final edition of our paper 1 .…”

mentioning

confidence: 96%

Response to Commentary on “The neuroinvasive potential of SARS‐CoV‐2 may play a role in the respiratory failure of COVID‐19 patients”

Bai²,

Hashikawa

2020

Journal of Medical Virology

136

106

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In a recent review, we have suggested a neuroinvasive potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its possible role in the causation of acute respiratory failure of coronavirus disease 2019 (COVID-19) patients (J Med Viol doi: 10.1002/jmv.25728), based upon the clinical and experimental data available on the past SARS-CoV-1 and the recent SARS-CoV-2 pandemic. In this article, we provide new evidence recently reported regarding the neurotropic potential of

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Global approaches for global challenges: The possible support of rehabilitation in the management of COVID‐19

Cited by 34 publications

References 10 publications

Rehabilitation of patients post-COVID-19 infection: a literature review

Rehabilitation of patients post-COVID-19 infection: a literature review

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Response to Commentary on “The neuroinvasive potential of SARS‐CoV‐2 may play a role in the respiratory failure of COVID‐19 patients”

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