Global COVID-19 pandemic demands joint interventions for the suppression of future waves

Li, Ruiyun; Чэн, Бин; Zhang, Tao; Ren, Zhehao; Song, Yimeng; Ying, Xiao; Hou, Lin; Cai, Jun; Xu, Bo; Li, Miao; Chan, Karen Kie Yan; Tu, Ying; Yang, Mu; Yang, Jing; Shen, Chong; Wang, Che; Xu, Lei; Liu, Qiyong; Bao, Shuming; Zhang, Jianqin; Bi, Yang; Bai, Yuqi; Deng, Ke; Zhang, Wusheng; Huang, Wenyu; Whittington, Jason D.; Stenseth, Nils Christian; Guan, Dabo; Gong, Peng; Xu, Bing

doi:10.1073/pnas.2012002117

Cited by 36 publications

(27 citation statements)

References 36 publications

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“…Ideally, we would hope to see a gradual decline in both the silent index and the number of new cases in the future. To achieve this goal, we need more intelligent social governance, collaboration on global efforts for prompt and intensive intervention 47 , more effective medical protection measures, more motivated and educated population practicing evidence-based selfprotection actions, especially in low-and middle-income countries 48 .…”

Section: Discussionmentioning

confidence: 99%

Silent world under COVID-19 — a comprehensive impact analysis based on human mobility

Wang

Tong

Fan

et al. 2021

Preprint

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Since spring 2020, the human world seems to be exceptionally silent due to mobility reduction caused by COVID-19 pandemic. To better measure real-time decline of human mobility and changes of socio-economic activities in a timely manner, we constructed a silent index (SI) based on Google’s mobility data. We systematically investigated the relations between SI, new COVID-19 cases, government policy, and the level of economic development. Results showed a drastic impact of the COVID-19 pandemic on increasing SI. The impact of COVID-19 on human mobility varied significantly by country and places. Bi-directional causality between SI and the new COVID-19 cases was detected, with a lagging period of one to two weeks. The travel restriction and social policies could immediately affect SI in one week; however, could not effectively sustain in the long run. Underdeveloped countries are more affected by the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

Silent world under COVID-19 — a comprehensive impact analysis based on human mobility

Wang

Tong

Fan

et al. 2021

Preprint

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“…With limited available vaccines, much of the effort made has been to suppress rapid diffusion of the disease by implementing non-pharmaceutical interventions such as restricting human movements [ 3 ]. Other non-pharmaceutical interventions include wearing face masks, proper hand hygiene, or changing climate or weather conditions [ 4 , 5 ]. Among these, controlling inter- and intra-country mobility is a top-down action that can be more correctly and uniformly implemented than enforcement of mask wearing and similar measures, and is much more controllable than altering local climate or weather.…”

Section: Introductionmentioning

confidence: 99%

“…There have been much early studies focusing on the effect of travel restrictions or airport screening with other interventions via mathematical models [ 7 , 8 , 20 ]. However, few model findings have suggested a proper quarantine period [ 4 ]. Determining the approximate period during which imported cases can spark local outbreaks is critical, to better control travelers’ mobility and impede local transmission in a timely manner.…”

Section: Introductionmentioning

confidence: 99%

Reduction of Human Mobility Matters during Early COVID-19 Outbreaks: Evidence from India, Japan and China

Ren

Zhang

et al. 2021

IJERPH

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Mobility restrictions have been a heated topic during the global pandemic of coronavirus disease 2019 (COVID-19). However, multiple recent findings have verified its importance in blocking virus spread. Evidence on the association between mobility, cases imported from abroad and local medical resource supplies is limited. To reveal the association, this study quantified the importance of inter- and intra-country mobility in containing virus spread and avoiding hospitalizations during early stages of COVID-19 outbreaks in India, Japan, and China. We calculated the time-varying reproductive number (Rt) and duration from illness onset to diagnosis confirmation (Doc), to represent conditions of virus spread and hospital bed shortages, respectively. Results showed that inter-country mobility fluctuation could explain 80%, 35%, and 12% of the variance in imported cases and could prevent 20 million, 5 million, and 40 million imported cases in India, Japan and China, respectively. The critical time for screening and monitoring of imported cases is 2 weeks at minimum and 4 weeks at maximum, according to the time when the Pearson’s Rs between Rt and imported cases reaches a peak (>0.8). We also found that if local transmission is initiated, a 1% increase in intra-country mobility would result in 1430 (±501), 109 (±181), and 10 (±1) additional bed shortages, as estimated using the Doc in India, Japan, and China, respectively. Our findings provide vital reference for governments to tailor their pre-vaccination policies regarding mobility, especially during future epidemic waves of COVID-19 or similar severe epidemic outbreaks.

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“…Malaria is still a worldwide life-threatening infection disease especially during the COVID-19 pandemic [1,2]. In 2018, malaria caused estimated 218 million cases and 405 thousand deaths over the world.…”

Section: Introductionmentioning

confidence: 99%

The Dynamic Landscape of Parasitaemia Dependent Intestinal Microbiota Shifting at Species Level and the Correlated Gut Transcriptome During Plasmodium Yoelii Infection

Zong

Cheng

et al. 2020

Preprint

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BackgroundMalaria, caused by Plasmodium infection, is a global life-threatening infection disease especially during the COVID-19 pandemic. However, it is still unclear about the dynamic change and the interactions of the intestinal microbiota and immunity during the whole parasite infection. Here, we investigated the change of intestinal microbiome and transcriptome during the whole Plasmodium infection process in mice to analyze the dynamic landscape of parasitaemia dependent intestinal microbiota shifting and related to host immunity.ResultsThere were significant parasitaemia dependent changes of intestinal microbiota and transcriptome, and the microbiota was significantly correlated to the intestinal immunity. We found that (i) the diversity and composition of the intestinal microbiota represented a significant correlation along with the Plasmodium infection in family, genus and species level; (ii) particularly, Erysipelotrichaceae bacterium canine oral taxon 255, Sutterella*, Ruminococcus 1* and Eubacterium plexicaudatum ASF492 were specific during the parasitaemia rising state, while Eubacterium nodatum group* was specific in the recovering phase at species level; (iii) the up-regulated genes from the intestinal transcriptome were mainly enriched in immune cell differentiation pathways along with the malaria development, particularly, naive CD4+ T cells differentiated into Th1, Th2 and Tfh cells in the early immune response and into Th17 cells in the later response, while B cells were activated during the whole Plasmodium infection process; (iv) the abundance of the parasitaemia phase-specific microbiota represented a high correlation with the phase-specific immune cells development, particularly, Th1 cell with family Bacteroidales BS11 gut group, genera Prevotella 9, Ruminococcaceae UCG 008, Moryella and specie Sutterella* , Th2 cell with specie Sutterella*, Th17 cell with family Peptococcaceae , genus Lachnospiraceae FCS020 group and spices Ruminococcus 1*, Ruminococcus UGG 014* and Eubacterium plexicaudatum ASF492, Tfh and B cell with genera Moryella and species Erysipelotrichaceae bacterium canine oral taxon 255.ConclusionThere were a remarkable dynamic landscape of the parasitaemia dependent shifting of intestinal microbiota and immunity, and a notable correlation between the abundance of intestinal microbiota, especially at species level, and immune cells.

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Global COVID-19 pandemic demands joint interventions for the suppression of future waves

Cited by 36 publications

References 36 publications

Silent world under COVID-19 — a comprehensive impact analysis based on human mobility

Silent world under COVID-19 — a comprehensive impact analysis based on human mobility

Reduction of Human Mobility Matters during Early COVID-19 Outbreaks: Evidence from India, Japan and China

The Dynamic Landscape of Parasitaemia Dependent Intestinal Microbiota Shifting at Species Level and the Correlated Gut Transcriptome During Plasmodium Yoelii Infection

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