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Liu, Keying; Peng, Li; Wang, Zhong

doi:10.1155/2017/1295089

Cited by 2 publications

(4 citation statements)

References 34 publications

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“…Class 1 and Class 2.1 metabolites are further oxidized or conjugated to hydroxylated PCB 11 sulfate (Class 2.2) and glucuronide metabolites (Class 2.3), respectively. Hydroxylated PCB sulfates have been detected in rats [85][86][87] and polar bears, 30 whereas no hydroxylated PCB 11 glucuronides have been reported to-date. There is also evidence that these metabolites are formed in mice; however, it is unknown if these metabolites were PCB sulfates or glucuronides.…”

Section: Proposed Metabolic Pathways Of Pcb 11 In Hepg2 Cellsmentioning

confidence: 99%

“…[25][26][27] Moreover, 4-OH-PCB 11 is likely a substrate for UDPglucuronosyltransferases (UGTs) and, as with other hydroxylated PCBs, 28,29 likely metabolized to a glucuronide in vivo. As suggested from observations with polar bears, 30 hydroxylated, sulfated and glucuronidated PCB 11 metabolites may be further oxidized to diverse di-and tri-hydroxylated metabolites.…”

Section: Introductionmentioning

confidence: 96%

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3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

Zhang

Flor

Ruíz

et al. 2020

Environ. Sci. Technol.

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3,3'-Dichlorobiphenyl (PCB 11) is a byproduct of industrial processes and detected in environmental samples. PCB 11 and its metabolites are present in human serum, and emerging evidence demonstrates that PCB 11 is a developmental neurotoxicant. However, little is known about the metabolism of PCB 11 in humans. Here we investigated the metabolism of PCB 11 and the associated metabolomics changes in HepG2 cells using untargeted high-resolution mass spectrometry. HepG2 cells were exposed for 24 h to PCB 11 in DMSO or DMSO alone. Cell culture media were analyzed with ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry. Thirty different metabolites were formed by HepG2 cells exposed to 10 μM PCB 11, including monohydroxylated, dihydroxylated, hydroxylatedmethoxylated, and methoxylated-di-hydroxylated metabolites, and the corresponding sulfo and glucuronide conjugates. The methoxylated PCB metabolites were observed for the first time in a human-relevant model. 4-OH-PCB 11 (3,3'-dichlorobiphenyl-4-ol) and the corresponding catechol metabolite, 4,5-di-OH-PCB 11 (3',5-dichloro-3,4-dihydroxybiphenyl), were unambiguously

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Section: Proposed Metabolic Pathways Of Pcb 11 In Hepg2 Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

Zhang

Flor

Ruíz

et al. 2020

Environ. Sci. Technol.

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“…11 As a passive sampling device, silicone wristbands non-selectively sequester bioavailable volatile and semi-volatile organic compounds via diffusion, similar to a phospholipid membrane. 11 The bioavailable fraction is significant for inhalation and dermal exposure routes in humans, [12][13][14][15] and these exposure routes can significantly increase the risk of adverse health outcomes. [13][14] Silicone wristbands have been used to assess exposure for VOCs in asphalt workers, 11 flame retardants for preschool age children, 12 pesticides for farm workers in Africa, and pesticides for people living in both agricultural and urban communities in Peru.…”

Section: Introductionmentioning

confidence: 99%

“…11 The bioavailable fraction is significant for inhalation and dermal exposure routes in humans, [12][13][14][15] and these exposure routes can significantly increase the risk of adverse health outcomes. [13][14] Silicone wristbands have been used to assess exposure for VOCs in asphalt workers, 11 flame retardants for preschool age children, 12 pesticides for farm workers in Africa, and pesticides for people living in both agricultural and urban communities in Peru. Because silicone wristbands provide the capacity to measure personal exposures to pesticides both at home and away, they present an opportunity to examine predictors and correlates of exposure.…”

Section: Introductionmentioning

confidence: 99%

Determinants of pesticide concentrations in silicone wristbands worn by Latina adolescent girls in a California farmworker community: The COSECHA youth participatory action study

Harley

Parra

Camacho

et al. 2019

Science of The Total Environment

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Personal exposure to pesticides has not been well characterized, especially among adolescents. We used silicone wristbands to assess pesticide exposure in 14 to 16 year old Latina girls (N = 97) living in the agricultural Salinas Valley, California, USA and enrolled in the COSECHA (CHAMACOS of Salinas Examining Chemicals in Homes and Agriculture) Study, a youth participatory action study in an agricultural region of California. We determined pesticide concentrations (ng/g/day) in silicone wristbands worn for one week using gas chromatography electron capture detection and employed gas chromatography mass spectrometry to determine the presence or absence of over 1500 chemicals. Predictors of pesticide detections and concentrations were identified using logistic regression, Wilcoxon rank sum tests, and Tobit regression models. The most frequently detected pesticides in wristbands were fipronil sulfide (87%), cypermethrin (56%), dichlorodiphenyldichloroethylene (DDE) (56%), dacthal (53%), and trans-permethrin (52%). Living within 100 m of active agricultural fields, having carpeting in the home, and having an exterminator treat the home in the past six months were associated with higher odds of detecting certain pesticides. Permethrin concentrations were lower for participants who cleaned their homes daily (GM: 1.9 vs. 6.8 ng/g/day, p= 0.01). In multivariable regression models, participants with doormats in the entryway of their home had lower concentrations (p<0.05) of cypermethrin (87%), permethrin (99%), fipronil sulfide (69%) and DDE (75%). The results suggest that both nearby agricultural pesticide use and individual behaviors are associated with pesticide exposures.

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Global Dynamics of Rational Difference Equations xn+1=xn+x

Cited by 2 publications

References 34 publications

3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

3,3′-Dichlorobiphenyl Is Metabolized to a Complex Mixture of Oxidative Metabolites, Including Novel Methoxylated Metabolites, by HepG2 Cells

Determinants of pesticide concentrations in silicone wristbands worn by Latina adolescent girls in a California farmworker community: The COSECHA youth participatory action study

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