2007
DOI: 10.1021/es071785c
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Global Gene Expression Profiling of Androgen Disruption in Qurt Strain Medaka

Abstract: Androgen disrupting chemicals (ADCs) are endocrine disrupting chemicals (EDCs) that mimic or antagonize the effect of physiological androgens. Microarray-based detection of altered gene expression can be used as a biomarker of EDC exposure. Therefore, the purpose of this study was to identify and compare gene expression profiles of the androgen 11-ketotestosterone (11-KT), the antiandrogen flutamide (FLU), and the antiandrogenic fungicide vinclozolin (VIN), on Qurt medaka (Oryzias latipes). Biologically effect… Show more

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Cited by 24 publications
(20 citation statements)
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“…Certain genes such as esr2a and cyp19a1b were downregulated in medaka, which agrees with the response to flutamide as previously reported (Leon et al, 2008), involving the downregulation of esr2a and aromatase in 7-dph female medaka larvae. The same study also revealed the downregulation of gnrhr2 in male larvae, which was also observed in this study in 7-dpf medaka embryos.…”
Section: Modulation Of Embryonic Gene Expression By Anti-androgenssupporting
confidence: 91%
See 1 more Smart Citation
“…Certain genes such as esr2a and cyp19a1b were downregulated in medaka, which agrees with the response to flutamide as previously reported (Leon et al, 2008), involving the downregulation of esr2a and aromatase in 7-dph female medaka larvae. The same study also revealed the downregulation of gnrhr2 in male larvae, which was also observed in this study in 7-dpf medaka embryos.…”
Section: Modulation Of Embryonic Gene Expression By Anti-androgenssupporting
confidence: 91%
“…Because androgens are necessary for brain development, sexual differentiation and sexual behavior in male fish, the disruption of androgenic signaling in juveniles and adults can cause severe reproductive effects (Jobling et al, 2009;Leon et al, 2008;Oshima et al, 2003). Our results show that androgenic disruption is already evident at the molecular level in pre-hatch medaka embryos.…”
Section: Modulation Of Embryonic Gene Expression By Estrogensmentioning
confidence: 62%
“…For example, microarrays have been used to study effects of chemical stressors on commonly used fish models including fathead minnows (e.g., Larkin et al, 2007;Mager et al, 2008;Villeneuve et al, 2008), zebrafish (e.g., Hoffman et al, 2006Lam et al, 2006;Martyniuk et al, 2007), medaka (Oryzias latipes; e.g., Volz et al, 2006;Leon et al, 2008), rainbow trout (Oncorhychus mykiss; e.g., Hook et al, 2006), mummichog (Fundulus heteroclitus; e.g., Fisher and Oleksiak, 2007;Roling et al, 2007), and sheepshead minnow (Cyprinodon variegatus;Larkin et al, 2002;Knoebl et al, 2006). Other fish species examined in ecotoxicogenomic studies include common carp (Cyprinus carpio; e.g., Moens et al, 2006), goldfish (Carassius auratus; e.g., Martyniuk et al, 2006), the coral reef fish Pomacentrus moluccensis (Kassahn et al, 2007), largemouth bass (Micropterus salmoides; e.g., Garcia-Reyero et al, 2008), European flounder (Platichthys flesus; e.g., Williams et al, 2006), three-spined stickleback (Gasterosteus aculeatus; e.g., Geohegan et al, 2008), and Gobiocypris rarus (Wei et al, 2008).…”
Section: The Practice Of Ecotoxicogenomics: Transcriptomicsmentioning
confidence: 99%
“…For example, a number of studies have examined transcriptional responses to heavy metals, including copper, cadmium, zinc, arsenic, mercury, and chromium (Hook et al, 2006;Jamers et al, 2006;Klaper et al, 2006;Lam et al, 2006;Williams et al, 2006;Poynton et al, 2007;Watanabe et al, 2007;Bundy et al, 2008;Connon et al, 2008). Endocrine disrupting chemicals have also received considerable attention Helbing et al, 2007a;Benninghoff and Williams, 2008;Hoffmann et al, 2008;Kausch et al, 2008;Leon et al, 2008;Villeneuve et al, 2008). The prototypical estrogenic contaminant, ethynyl estradiol (EE2), alone has been investigated in at least eight independent transcriptomic experiments (Hoffmann et al, 2006;Hook et al, 2006;Martyniuk et al, 2006Martyniuk et al, , 2007Moens et al, 2006;Finne et al, 2007;Santos et al, 2007).…”
Section: The Practice Of Ecotoxicogenomics: Transcriptomicsmentioning
confidence: 99%
“…Ein ähnliches Verfahren gibt es für den Zebrabärbling (Danio rerio) (Martyniuk et al 2007). Auch Medaka (Oryzias latipes) wurde mit Hilfe von Microarrays auf androgene Substanzen untersucht, wobei insgesamt 1815 Gene von 9379 untersuchten Genen hoch-oder herunterreguliert wurden und 50 diagnostische Gene identifiziert werden, die charakteristische Genexpressionsprofile unter Androgeneinfluss aufweisen (Leon et al 2008). Genexpressionsanalysen haben den Vorteil, dass diverse endokrine (östrogen, androgen, thyroidal usw.)…”
Section: Ebenso Gibt Es Microarray-verfahren Mitunclassified