Global implementation of PrEP as part of combination HIV prevention - Unsolved challenges

Cáceres, Carlos; Bekker, Linda‐Gail; Godfrey‐Faussett, Peter

doi:10.7448/ias.19.7.21479

Cited by 1 publication

(1 citation statement)

References 245 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[13,18,19] However, despite the documented e cacy of oral PrEP, strategies for optimal scale-up and adherence remain unclear and the best oral PrEP delivery models in generalized epidemics are not known. [20,21,22,23,24,25] Adherence to oral PrEP use and retention in oral PrEP services range from 3.0-35.0% and are especially low in low-and middle-income countries. [26,27,28] With limited studies on the barriers to oral PrEP uptake, adherence, and retention among key populations, it is believed that the same factors impending HIV treatment are to blame for the challenges in oral PrEP use.…”

Section: Introductionmentioning

confidence: 99%

Oral Pre-Exposure Prophylaxis (PrEP) Awareness and Acceptability Among Persons who Inject Drugs (PWID) in Kenya: A Qualitative Investigation

Cosmas¹,

Mbogo

Sinkele³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: People who inject drugs (PWID) are disproportionately affected by HIV despite the availability of multiple efficacious biomedical prevention interventions including oral pre-exposure prophylaxis (PrEP). Little is known about the knowledge, acceptability, and uptake of oral PrEP among this population in Kenya. To inform the development of oral PrEP uptake optimization interventions for PWID in Kenya, we conducted a qualitative assessment to establish oral PrEP awareness and willingness to take PrEP by this group in Nairobi City. Methodology: Guided by the Capability, Opportunity, Motivation, and Behaviour (COM-B) model of health behavior change, we conducted 8 focus group discussions (FGDs) among randomly constituted samples of PWID in four harm reduction drop-in centers (DICs) in Nairobi in January 2022. The domains explored were: perceived risks (behaviour), oral PrEP awareness and knowledge (capability), motivation to use oral PrEP (behaviour), and perceptions on community uptake (motivation and opportunity). Completed FGD transcripts were uploaded to Atlas.ti version 9 and thematic analysis was conducted through an iterative process of review and discussion by two coders. Findings: There was a low level of oral PrEP awareness with only 4 of the 46 PWID having heard of PrEP; only 3 out of 46 participants had ever used oral PrEP and 2 out of 3 were no longer using it, indicating a low capacity to make decisions on oral PrEP. Most study participants were aware of the risk posed by unsafe drug injection and expressed willingness to take oral PrEP. Nearly all participants demonstrated low understanding of the role oral PrEP plays in complementing condoms in HIV prevention, presenting an opportunity for awareness creation. While the PWID were eager to learn more about oral PrEP, they favored DICs as places where they would like to obtain information and oral PrEP if they chose to use it, identifying an opportunity for oral PrEP programming interventions. Conclusion: Creation of oral PrEP awareness among PWID in Kenya is likely to improve uptake since the PWID are receptive. Oral PrEP should be offered as part of combination prevention approaches, and effective messaging through DICs, integrated outreaches, and social networks are recommended to mitigate displacement of other prevention and harm reduction practices by this population. Trial Registration: ClinicalTrials.gov Protocol Record STUDY0001370.

show abstract