Global Initiative for Interdisciplinary Approach to Improve Innovative Clinical Research and Treatment Outcomes in Geriatrics: Biological Cell-Based Targeted Drug Delivery Systems for Geriatrics

Abstract

At the intersection of the late 20(th) century and early 21(st) century, a worldwide challenge began to emerge--how can the quality of life be improved for a steadily increasing elderly population. It is well known that elderly patients show increased susceptibility to infections and a higher incidence of co-morbidity rates. Older adults frequently demonstrate pharmacokinetic and pharmacodynamic changes promoting adverse drug reactions and complications. Analysis of world literature and practical observations indicate that new approaches are required in gerontology and geriatric medicine due to recent significant advances in biomedical science. Global interdisciplinary approaches to improve medical science and medical care services for growing elderly population are indicated. This global, interdisciplinary initiative should integrate select, tangible clinical results achieved in leading research centers and universities that are applicable in the field of geriatrics and helpful to geriatricians. Among past scientific and clinically significant study results in the field of biomedicine, one must consider targeted drug delivery systems (DDS), which are designed to minimize drug side effects, increase the efficacy of drugs, and prolong and target drug interactions with particular pathological foci in sick patients. Many review articles focus on various methods of drug encapsulation and pharmacokinetics, but not on developing clinical modalities. This article attempts to further the discussion with researchers and clinicians from various fields, as well as to encourage comprehensive and elderly patient-oriented research focused on clinical implementation of DDS, especially erythrocyte-based DDS.

Drug-loaded erythrocytes: Modern approaches for advanced drug delivery for clinical use

“…A new method for the local treatment of purulent wounds by topical application of autologous pharmacocytes containing antibiotics and cytokines has been developed for use in preclinical studies. The pharmacokinetics and toxicity of these drugs have been studied [ 102 , 103 , [113] , [114] , [115] , [116] , [117] , [118] , [119] ]. Based on extensive experimental and clinical trials, the possibility of using autologous erythrocyte ghosts containing an antibiotic and cytokine to improve the results of surgical infection treatment has been proven.…”

Commentary on Some Recent Theses Relevant to Combating Aging: February 2015

“…A potential stumbling block posed by the receptor's ill-understood pro-inflammatory signaling role remains to be navigated. Fortunately treatments for age-related waste (in contrast to those for congenital LSDs, where accumulation is faster) should not require particularly frequent or intensive administration; as-required low-level background delivery via engineered blood cells 22,23 would be one viable approach.…”