Global interventions in hypertension: new and emerging concepts

Ferdinand, Keith C.; Reddy, Tina K.; Vo, Thanh N.

doi:10.1097/hco.0000000000000866

Cited by 10 publications

(5 citation statements)

References 79 publications

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“…Obesity and hypertension, two major risk factors for CVD, contribute to global health and economic burdens (1,2,5,6,41). Given the dramatic increase in hypertension with the significant rise in obesity, early detection of hypertension using ORI screening could effectively prevent future hypertension and CVD risk.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of 10 obesity-related indices for predicting hypertension based on ROC analysis in Chinese adults

Lee

Gao

Zhang

et al. 2022

Front. Public Health

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ObjectiveTo compare the predictive performance of the percentage body fat (PBF), body mass index (BMI), waist circumference (WC), hip circumference (HC), waist–hip ratio (WHR), waist–height ratio (WHtR), a body shape index (ABSI), body roundness index (BRI), abdominal volume index (AVI), and conicity index (CI) for identifying hypertension.MethodsA cross-sectional study was conducted among 2,801 adults (1,499 men and 1,302 women) aged 18 to 81 in Ningbo, China. The receiver operator characteristic (ROC) analysis and multiple non-parametric Z tests were used to compare the areas under the curve (AUC). The maximum Youden's indices were used to determine the optimal cut-off points of 10 obesity-related indices (ORI) for hypertension risk.ResultsThe AUC of all the indices were statistically significant (P < 0.05). The AUC of all the indices in men and women were 0.67–0.73 and 0.72–0.79, respectively. Further non-parametric Z tests showed that WHR had the highest AUC values in both men [0.73 (95% CI: 0.70, 0.76)] and women (0.79 (95% CI: 0.75, 0.83)], and several central ORI (men: WHR, WC, BRI, AVI, and CI, 0.71–0.73; women: WC, WHR, and AVI, 0.77–0.79) were higher than general ORI (PBF and BMI, 0.68 in men; 0.72–0.75 in women), with adjusted P < 0.05. The optimal cut-off points for identifying hypertension in men and women were as follows: PBF (23.55%, 32.55%), BMI (25.72 kg/m2, 23.46 kg/m2), HC (97.59 cm, 94.82 cm), WC (90.26 cm, 82.78 cm), WHR (0.91, 0.88), WHtR (0.51, 0.55), ABSI (0.08 m7/6/kg2/3, 0.08 m7/6/kg2/3), BRI (4.05, 4.32), AVI (16.31 cm2, 13.83 cm2), and CI (1.23 m2/3/kg1/2, 1.27 m2/3/kg1/2). Multivariate logistic regression models showed that all indices were statistically significant (P < 0.05) with the adjusted ORs (per 1-SD increase) at 1.39–2.06 and ORs (over the optimal cut-off points) at 1.80–2.64.ConclusionsAll 10 ORI (PBF, BMI, HC, WC, WHR, WHtR, ABSI, BRI, AVI, and CI) can effectively predict hypertension, among which WHR should be recommended as the best predictor. Central ORI (WHR, WC, and AVI) had a better predictive performance than general ORIs (PBF and BMI) when predicting the risk of hypertension.

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Section: Discussionmentioning

confidence: 99%

“…Hypertension is a risk factor for cardiovascular diseases (CVD) and death; thus, it is an essential global health threat (1,2). A nationwide epidemiological study involving 451,755 residents from 31 provinces in China showed that the prevalence of hypertension among adults in China was 23.2% (3).…”

Section: Introductionmentioning

confidence: 99%

Comparison of 10 obesity-related indices for predicting hypertension based on ROC analysis in Chinese adults

Lee

Gao

Zhang

et al. 2022

Front. Public Health

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“…Hypertension is a critical risk factor for cardiovascular disease [ 1 ]. The prevalence of hypertension has been increasing worldwide year by year.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of melatonin on myocardial microvascular endothelial cell injury under hypertensive state by regulating Mst1

Wang

Han

et al. 2023

BMC Cardiovasc Disord

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Background This study explored the protective effects of melatonin on the hypertensive model in myocardial microvascular endothelial cells. Methods Mouse myocardial microvascular endothelial cells were intervened with angiotensin II to establish hypertensive cell model and divided into control, hypertension (HP), hypertension + adenovirus negative control (HP + Ad-NC), hypertension + adenovirus carrying Mst1 (HP + Ad-Mst1), hypertension + melatonin (HP + MT), hypertension + adenovirus negative control + melatonin (HP + Ad-NC + MT), and hypertension + adenovirus carrying Mst1 + melatonin (HP + Ad-Mst1 + MT) groups. Autophagosomes were observed by transmission electron microscope. Mitochondrial membrane potential was detected by JC-1 staining. Apoptosis was detected by flow cytometry. Oxidative stress markers of MDA, SOD and GSH-PX were measured. The expression of LC3 and p62 was detected by immunofluorescence. Expression levels of Mst1, p-Mst1, Beclin1, LC3, and P62 were detected with Western blot. Results Compared with the control group, the autophagosomes in HP, HP + Ad-Mst1, and HP + Ad-NC groups were significantly reduced. Compared with HP group, the autophagosomes in HP + Ad-Mst1 group were significantly reduced. The apoptosis of HP + MT group was significantly lower than HP group. Compared with HP + Ad-Mst1 group, the apoptosis of HP + Ad-Mst1 + MT group was significantly reduced. The ratio of JC-1 monomer in HP + MT group was significantly lower than HP group. Compared with HP + Ad-Mst1 group, the mitochondrial membrane potential of HP + Ad-Mst1 + MT group was also significantly reduced. MDA content in HP + MT group was significantly reduced, but SOD and GSH-PX activities were significantly increased. Compared with HP + Ad-Mst1 group, MDA content in HP + Ad-Mst1 + MT group was significantly reduced, whereas SOD and GSH-PX activities were increased significantly. Mst1 and p-Mst1 proteins in HP + MT group were significantly reduced. Compared with HP + Ad-Mst1 group, Mst1 and p-Mst1 in HP + Ad-Mst1 + MT group were reduced. P62 level was significantly decreased, while Beclin1 and LC3II levels were significantly increased. P62 in HP + MT group was significantly reduced, while Beclin1 and LC3II were significantly increased. Compared with HP + Ad-Mst1 group, P62 in HP + Ad-Mst1 + MT group was significantly reduced, but Beclin1 and LC3II were significantly increased. Conclusion Melatonin may inhibit apoptosis, increase mitochondrial membrane potential, and increase autophagy of myocardial microvascular endothelial cells under hypertensive state via inhibiting Mst1 expression, thereby exerting myocardial protective effect.

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“…Ten million people in the world will have died of cancer in 2020 [ 4 ]. Hypertension is the main risk factor for cardio-cerebrovascular disease [ 5 ]. Globally, more than a quarter of the population is hypertensive [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study Reveals the Genetic Basis of Total Flavonoid Content in Brown Rice

Xia,

Pu,

Zhu

et al. 2023

Genes

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Flavonoids have anti-inflammatory, antioxidative, and anticarcinogenic effects. Breeding rice varieties rich in flavonoids can prevent chronic diseases such as cancer and cardio-cerebrovascular diseases. However, most of the genes reported are known to regulate flavonoid content in leaves or seedlings. To further elucidate the genetic basis of flavonoid content in rice grains and identify germplasm rich in flavonoids in grains, a set of rice core collections containing 633 accessions from 32 countries was used to determine total flavonoid content (TFC) in brown rice. We identified ten excellent germplasms with TFC exceeding 300 mg/100 g. Using a compressed mixed linear model, a total of 53 quantitative trait loci (QTLs) were detected through a genome-wide association study (GWAS). By combining linkage disequilibrium (LD) analysis, location of significant single nucleotide polymorphisms (SNPs), gene expression, and haplotype analysis, eight candidate genes were identified from two important QTLs (qTFC1-6 and qTFC9-7), among which LOC_Os01g59440 and LOC_Os09g24260 are the most likely candidate genes. We also analyzed the geographic distribution and breeding utilization of favorable haplotypes of the two genes. Our findings provide insights into the genetic basis of TFC in brown rice and could facilitate the breeding of flavonoid-rich varieties, which may be a prevention and adjuvant treatment for cancer and cardio-cerebrovascular diseases.

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Global interventions in hypertension: new and emerging concepts

Cited by 10 publications

References 79 publications

Comparison of 10 obesity-related indices for predicting hypertension based on ROC analysis in Chinese adults

Comparison of 10 obesity-related indices for predicting hypertension based on ROC analysis in Chinese adults

Protective effects of melatonin on myocardial microvascular endothelial cell injury under hypertensive state by regulating Mst1

Genome-Wide Association Study Reveals the Genetic Basis of Total Flavonoid Content in Brown Rice

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