Global Left Ventricular Relaxation: A Useful Echocardiographic Marker of Heart Transplant Rejection and Recovery in Children

Hernandez, Lazaro E.; Chrisant, Maryanne; Valdes‐Cruz, Lilliam M.

doi:10.1016/j.echo.2018.11.010

Cited by 10 publications

(2 citation statements)

References 21 publications

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“…By using well-defined TDI criteria to predict non-rejection, a substantial proportion of planned biopsies can be deferred or avoided in pediatric HT recipients. In addition, many recent studies suggested that TDI parameters help discriminate rejection from non-rejection and can be used as noninvasive surveillance alternatives to EMB [16,20,21]. An example of abnormal LV myocardial velocities in pediatric HT recipients with confirmed rejection by EMB (Grade 2R acute cellular rejection) and normal TDI in another HT of the same age patient are shown in Figure 2A-D, respectively.…”

Section: Tissue Doppler Imagingmentioning

confidence: 99%

Multimodality Imaging to Detect Rejection, and Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients—An Illustrative Review

Das

Deshpande

Hussain³

2022

Transplantology

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The three most common modalities of graft surveillance in pediatric heart transplant (HT) recipients include echocardiography, coronary angiography, and endomyocardial biopsy (EMB). The survival outcomes after HT in children have improved considerably in recent years. However, allograft rejection and cardiac allograft vasculopathy remain the leading cause of death or re-transplantation. The routine surveillance by EMB and coronary angiography are invasive and risky. Newer noninvasive echocardiographic techniques, including tissue Doppler imaging (TDI), 2-D speckle tracking echocardiography, CT coronary angiography (CTCA), cardiovascular magnetic resonance (CMR), single-photon emission computed tomography (SPECT), and positron emission tomography (PET) and invasive techniques such as intravascular ultrasound (IVUS), functional flow reserve (CFR) of coronary arteries, optical coherence tomography (OCT), have emerged as powerful tools which may help early recognition of sub-clinical rejection, response to treatment, early detection, and progression of CAV. The multimodality imaging approach, including noninvasive and invasive tests, is the future for the transplanted heart to detect dysfunction, rejections, and early CAV. This review illustrates noninvasive and invasive imaging techniques currently used or could be considered for clinical use in detecting heart transplant rejection, dysfunction, and CAV in children.

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Section: Tissue Doppler Imagingmentioning

confidence: 99%

Multimodality Imaging to Detect Rejection, and Cardiac Allograft Vasculopathy in Pediatric Heart Transplant Recipients—An Illustrative Review

Das

Deshpande

Hussain³

2022

Transplantology

View full text Add to dashboard Cite

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“…A 2019 analysis of all adults who underwent heart transplantation in United States hospitals from 2004 to 2014 included 93 Fontan patients and found their in-hospital post-transplantation mortality to be 5 times that of non-Fontan recipients (26% vs 5%; P < 0.001). 143 Emerging data are pointing toward potential benefit in lymphatic drainage interventions or external ventilation strategies, although further study is required before these options can be more widely applied in clinical practice. 144,145…”

Section: Knowledge Gaps and Future Directionsmentioning

confidence: 99%