Global Longitudinal Strain and Strain Rate in Type Two Diabetes Patients with Chronic Heart Failure: Relevance to Osteoprotegerin

Kružliak, Peter; Berezin, Alexander E.; Kremzer, Alexander A.; Samura, Tatyana A.; Benacka, R; Mozoş, Ioana; Egom, Emmanuel E.; Rodrigo, Luís

doi:10.1515/folmed-2016-0021

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…For example, renal dysfunction is a common consequence of diabetes and may contribute to the enhanced risk of heart failure (although baseline creatinine was similar in patients with and without diabetes). 21,22 Interestingly, heart rate was higher in patients with diabetes despite a similar prevalence of atrial fibrillation and similar use of beta-blockers and digoxin in patients with and without diabetes. It is possible that autonomic neuropathy might also contribute to the HF risk related to diabetes and this finding is also of interest in light of the benefit of heart rate-lowering therapy in patients with heart failure and reduced ejection fraction.…”

Section: Discussionmentioning

confidence: 99%

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

et al. 2018

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“…Although we discussed the advantages of GLS as a quantitative indicator in identifying early left ventricular dysfunction, previous studies suggested that the measurement of GLS in diabetes with chronic heart failure was also affected by inflammatory activity and biomechanical stress indicators, such as NT-proBNP, high sensitivity C reactive protein and osteoprotegerin, which could affect the tension and flexibility of the myocardial wall. 29 Using these biomarkers as predictors or risk stratification tools is also critical for comprehensive evaluation of left ventricular function in patients in the future.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Masked Hypertension Measured by Ambulatory Blood Pressure Monitoring and Left Ventricular Global Longitudinal Strain: A Retrospective Study

Fu¹,

Hu²,

Sun³

et al. 2021

IJGM

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Masked hypertension (MHT), as an independent clinical entity, the cardiac dysfunction caused by it can be early detected through left ventricular global longitudinal strain (GLS), yet the quantitative relation between MHT and GLS is still unclear. Therefore, we tried to conduct a community-based retrospective study to define this relationship. Patients and Methods: A total of 308 enrolled participants from Dongguan, China, were divided into non-hypertension (NHT) and MHT groups. Baseline characteristics were recorded, and echocardiography and 24-hour ambulatory blood pressure monitoring were performed. Linear regression analysis and receiver-operating characteristic (ROC) curve analysis were used to assess the associations between MHT and GLS in univariate and multivariate models, and the dose-response curve was plotted to demonstrate their relationship. Results: The mean age of the NHT and MHT groups was 57 and 60 years, respectively. Signs of left ventricular diastolic function, E/A was reduced and E/e' was increased in the MHT group while those of the NHT group were nearly normal. The MHT group also showed a significantly lower ("worse") GLS than NHT (−15.2% vs −19.9%, P < 0.001) while left ventricular ejection fraction (LVEF) did not differ between the groups. Worse GLS was independently and significantly associated with MHT both in univariate (odds ratio [OR]: 1.97, P < 0.001) and stepwise multivariate regression analysis (OR: 1.99, P < 0.001). Comparison of ROC curve results showed that area under curve of GLS was larger than that of E/e' both in unadjusted (0.8673 vs 0.6831) and adjusted model (0.9178 vs 0.8284). Further analysis showed adjusted nonlinear correlation between MHT and GLS. Conclusion:Based on the relationship between MHT and GLS, in clinical practice, GLS measurement could facilitate diagnosis for suspected MHT patients and could define the extent of left ventricular dysfunction for diagnosed MHT patients.

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“…Two recent studies have shown an association of OPG with global longitudinal strain, a marker of subclinical LV dysfunction in diabetic hypertensive patients [ 34 ] and diabetic patients with heart failure [ 35 ]. Global longitudinal strain is a well validated and reproducible technique for the measurement of ventricular longitudinal deformation with predictive value regarding all-cause mortality, as well as a composite of cardiac death, malignant arrhythmia, hospitalization due to heart failure, urgent valve surgery or heart transplantation, and acute coronary ischemia [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, we show for the first time an association between OPG levels and cardiac dysfunction in ESRD. It is tempting to speculate that the relationship between OPG and mortality in hemodialysis patients may be related, at least in part, to its putative association with the uremic cardiomyopathy, as has been proposed for the diabetic cardiomyopathy [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function

et al. 2017

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BackgroundTo assess whether serum osteoprotegerin (OPG) and/or fetuin-A predict mortality and cardiovascular (CV) morbidity and mortality in hemodialysis patients.MethodsMulticenter, observational, prospective study that included 220 hemodialysis patients followed up for up to 6 years. Serum OPG and fetuin-A levels were measured at baseline and their possible association with clinical characteristics, CV risk biomarkers, carotid ultrasonographic findings, as well as their association with overall and CV mortality and CV events were assessed.ResultsDuring a mean follow-up of 3.22 ± 1.91 years, there were 74 deaths (33.6%) and 86 new cardiovascular events. In the Kaplan-Meier survival analysis, the highest tertile of OPG levels was associated with higher overall mortality (p = 0.005), as well as a higher, although non-significant, incidence of CV events and CV mortality. In contrast, fetuin-A levels did not predict any of these events. OPG levels were directly associated with age, the Charlson comorbidity index (CCI), prevalent cardiovascular disease, carotid intima-media thickness, adiponectin, troponin-I and brain natriuretic peptide (BNP). OPG showed a negative correlation with left ventricular ejection fraction (LVEF) and phosphate levels. In the multivariate Cox proportional hazard analysis, all-cause mortality was associated with the highest tertile of OPG (HR:1.957, p = 0.018), age (HR:1.031, p = 0.036), smoking history (HR:2.122, p = 0.005), the CCI (HR:1.254, p = 0.004), troponin-I (HR:3.894, p = 0.042), IL-18 (HR:1.061, p < 0.001) and albumin levels (HR:0.886, p < 0.001). In the bootstrapping Cox regression analysis, the best cut-off value of OPG associated with mortality was 17.69 pmol/L (95%CI: 5.1–18.02).ConclusionsOPG, but not fetuin-A levels, are independently associated with overall mortality, as well as clinical and subclinical atherosclerosis and cardiac function, in prevalent hemodialysis patients.Electronic supplementary materialThe online version of this article (10.1186/s12882-017-0701-8) contains supplementary material, which is available to authorized users.

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Global Longitudinal Strain and Strain Rate in Type Two Diabetes Patients with Chronic Heart Failure: Relevance to Osteoprotegerin

Abstract: We suggest that osteoprotegerin may be useful in improving the NT-proBNP based model as predictor of decreased global contractility function in diabetic patients with CHF.

Cited by 6 publications

References 33 publications

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

Relationship Between Masked Hypertension Measured by Ambulatory Blood Pressure Monitoring and Left Ventricular Global Longitudinal Strain: A Retrospective Study

Serum osteoprotegerin in prevalent hemodialysis patients: associations with mortality, atherosclerosis and cardiac function

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