Global patterns and trends in colorectal cancer incidence and mortality

Arnold, Melina; Sierra, Mónica S.; Laversanne, Mathieu; Soerjomataram, Isabelle; Jemal, Ahmedin; Bray, Freddie

doi:10.1136/gutjnl-2015-310912

Cited by 3,994 publications

(3,200 citation statements)

References 50 publications

(41 reference statements)

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“…The trend of increasing incidence and decreasing mortality of CRC patients is in line with trends in other Western countries (e.g., Canada, Sweden and the United Kingdom). The rising incidence rates may be accounted for by major risk factors such as lifestyle, obesity and dietary habits 23. Interestingly, the incidence of CRC patients has been declining in other Western countries such as the US, France and Australia.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the incidence of CRC patients has been declining in other Western countries such as the US, France and Australia. Even though this difference is often attributed to the adoption of a western lifestyle and the long‐term effects of screening for CRC, no concluding explanation exists 23, 24. In the United States, a rise in younger individuals being diagnosed with CRC has been shown, whereas the total incidence of CRC is declining 24.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients

Brouwer

Bos

Lemmens

et al. 2018

Intl Journal of Cancer

241

193

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Regarding the continuous changes in the diagnostic process and treatment of colorectal cancer (CRC), it is important to evaluate long‐term trends which are relevant in giving direction for further research and innovations in cancer patient care. The aim of this study was to analyze developments in incidence, treatment and survival for patients diagnosed with CRC in the Netherlands. For this population‐based retrospective cohort study, all patients diagnosed with CRC between 1989 and 2014 in the Netherlands were identified using data of the nationwide population‐based Netherlands Cancer Registry (n = 267,765), with follow‐up until January 1, 2016. Analyses were performed for trends in incidence, mortality, stage distribution, treatment and relative survival measured from the time of diagnosis. The incidence of both colon and rectal cancer has risen. The use of postoperative chemotherapy for Stage III colon cancer increased (14–60%), as well as the use of preoperative (chemo)radiotherapy for rectal cancer (2–66%). The administration of systemic therapy and metastasectomy increased for Stage IV disease patients. The 5‐year relative survival increased significantly from 53 to 62% for colon cancer and from 51 to 65% for rectal cancer. Ongoing advancements in treatment, and also improvement in other factors in the care of CRC patients—such as diagnostics, dedicated surgery and pre‐ and postoperative care—lead to a continuous improvement in the relative survival of CRC patients. The increasing incidence of CRC favors the implementation of the screening program, of which the effects should be monitored closely.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients

Brouwer

Bos

Lemmens

et al. 2018

Intl Journal of Cancer

241

193

View full text Add to dashboard Cite

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“…CRC is the third-most commonly diagnosed malignancy and the fourth leading cause of cancer death in the world [1]. In the Inuit population, the incidence of CRC has increased rapidly over the last decades, possibly reflecting a change towards a more sedentary lifestyle and energy-dense diet [2].…”

Section: Introductionmentioning

confidence: 99%

Oncological treatment and outcome of colorectal cancer in Greenland

Odgaard

Lohse

Petersen

et al. 2018

International Journal of Circumpolar Health

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Oncological treatment of colorectal cancer (CRC) has been available in Greenland since 2004. Treatment is provided by Queen Ingrid´s Hospital (QIH), under supervision from the Department of Oncology, Rigshospitalet, Denmark. The study describes patient characteristics, oncological treatment and survival for the first 8 years of treatment. The study was a registry-based observational study of all patients in Greenland diagnosed with histologically verified CRC from August 2004 to August 2012. Analyses were stratified according to stage and discussed in relation to reported data from patients with CRC in Denmark. 180 patients were included. . Stage I, II, III, and IV comprised 15, 34, 23, and 23%, respectively. 5% presented with unknown stage. A total of 51% received oncological treatment. 79% of patients with Stage III disease received adjuvant chemotherapy, 61% of patients with metastatic CRC received palliative chemotherapy. Five-year survival was 48 and 53% for colon and rectum cancer, respectively. An insignificant trend towards higher survival in men than in women was seen; adjusted hazard ratio for death (women vs men) = 1.46 (95% CI = 0.97–2.19). In conclusion; Stage distribution, provision of oncological treatment and 5-year survival were comparable to patients diagnosed and treated in Denmark.

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“…Colorectal cancer (CRC) is the third most frequent cancer worldwide and ranks as the fourth leading cause of death from cancer (1). The risk of developing CRC in industrialized countries is between 5% and 6% and the mean age at diagnosis is 66 years.…”

Section: Introductionmentioning

confidence: 99%