2021
DOI: 10.1016/s2666-5247(21)00055-0
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Global patterns of submicroscopic Plasmodium falciparum malaria infection: insights from a systematic review and meta-analysis of population surveys

Abstract: Background Adoption of molecular techniques to detect Plasmodium falciparum infection has revealed many previously undetected (by microscopy) yet transmissible low-density infections. The proportion of these infections is typically highest in low transmission settings, but drivers of submicroscopic infection remain unclear. Here, we updated a previous systematic review of asexual P falciparum prevalence by microscopy PCR in the same population. We aimed to explore potential drivers of submicroscopic infection … Show more

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Cited by 40 publications
(55 citation statements)
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“…Submicroscopic malaria parasites among febrile patients have been enumerated; however, due to overlapping symptoms between malaria and other febrile diseases, highly sensitive POC diagnostic tests must be used for diagnosis [ 40 ]. Although submicroscopic malaria infections rarely cause clinical disease, in some cases severe and acute symptoms, such as mild anaemia, coughing, vomiting and jaundice, may develop as the disease progresses without appropriate treatment [ 41 ]. Early detection of submicroscopic malaria parasites is very important as it ensures appropriate treatment and the accurate determination of the malaria reservoir size [ 42 , 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…Submicroscopic malaria parasites among febrile patients have been enumerated; however, due to overlapping symptoms between malaria and other febrile diseases, highly sensitive POC diagnostic tests must be used for diagnosis [ 40 ]. Although submicroscopic malaria infections rarely cause clinical disease, in some cases severe and acute symptoms, such as mild anaemia, coughing, vomiting and jaundice, may develop as the disease progresses without appropriate treatment [ 41 ]. Early detection of submicroscopic malaria parasites is very important as it ensures appropriate treatment and the accurate determination of the malaria reservoir size [ 42 , 43 ].…”
Section: Discussionmentioning
confidence: 99%
“…P. falciparum, en raison de son tropisme pour les érythrocytes, donne essentiellement une symptomatologie fébrile, souvent mortelle surtout chez l'enfant, les femmes enceintes et les sujets non immuns qui arrivent en zone d'endémie (1)(2). La grande létalité associée à certaines formes comme l'anémie sévère et le neuropaludisme amène à envisager devant tout patient avec fièvre un diagnostic du paludisme quels que soient les signes cliniques qui accompagnent cette fièvre surtout si le patient vit en zone endémique (1).…”
Section: Introductionunclassified
“…Further, molecular approaches such as PCR are more sensitive than antigen testing, including the recently introduced "ultrasensitive rapid diagnostic tests" [9,10]. Apart from the diagnostic needs in resource-rich non-endemic settings, the suitability of highly sensitive real-time PCR assays has also been suggested for malaria eradication programs [11][12][13][14][15][16].…”
Section: Introductionmentioning
confidence: 99%
“…• Plasmodium falciparum mono-infections were detected by SybrGreen-based screening PCR with low cycle threshold values(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) and, thus, mixed plasmodial infections with severely dysbalanced parasitemia could not be excluded by melting curve analysis alone (n = 165).…”
mentioning
confidence: 99%