Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma

Paul, Debasish; Chanukuppa, Venkatesh; Reddy, Panga Jaipal; Taunk, Khushman; Adhav, Ragini; Srivastava, Sanjeeva; Santra, Manas Kumar; Rapole, Srikanth

doi:10.1016/j.jprot.2016.02.008

Cited by 33 publications

(23 citation statements)

References 33 publications

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“…However, following diagnosis, the life expectancy of patients is usually no longer than 6-12 months (9, 18,25,31). Etoposide, which belongs to the topoisomerase inhibitor family, is appropriate for use in GBM pharmacotherapy while also being an effective medium in GBM therapy (17,19). It is a widely used cancer drug that provides good results in the treatment of various Rosmarinus Officinalis is an aromatic, perennial plant that belongs to the Lamiaceae mint family.…”

Section: █ Introductionmentioning

confidence: 99%

The effect of rosmarinus officinalis and chemotherapeutic etoposide on glioblastoma (u87 mg) cell culture

Özdemir

Göktürk²

2017

Turkish Neurosurgery

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Section: █ Introductionmentioning

confidence: 99%

The effect of rosmarinus officinalis and chemotherapeutic etoposide on glioblastoma (u87 mg) cell culture

Özdemir

Göktürk²

2017

Turkish Neurosurgery

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“…By altering chromatin structure, epigenetic modifiers play an essential role in controlling pluripotency and differentiation in embryonic stem cells (ESCs) . Chemoresistance is among others mediated by SFPQ and BMI1 …”

Section: Resultsmentioning

confidence: 99%

The role of TCF3 as potential master regulator in blastemal Wilms tumors

Kehl

Schneider

Kattler

et al. 2018

Intl Journal of Cancer

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Wilms tumors are the most common type of pediatric kidney tumors. While the overall prognosis for patients is favorable, especially tumors that exhibit a blastemal subtype after preoperative chemotherapy have a poor prognosis. For an improved risk assessment and therapy stratification, it is essential to identify the driving factors that are distinctive for this aggressive subtype. In our study, we compared gene expression profiles of 33 tumor biopsies (17 blastemal and 16 other tumors) after neoadjuvant chemotherapy. The analysis of this dataset using the Regulator Gene Association Enrichment algorithm successfully identified several biomarkers and associated molecular mechanisms that distinguish between blastemal and nonblastemal Wilms tumors. Specifically, regulators involved in embryonic development and epigenetic processes like chromatin remodeling and histone modification play an essential role in blastemal tumors. In this context, we especially identified TCF3 as the central regulatory element. Furthermore, the comparison of ChIP-Seq data of Wilms tumor cell cultures from a blastemal mouse xenograft and a stromal tumor provided further evidence that the chromatin states of blastemal cells share characteristics with embryonic stem cells that are not present in the stromal tumor cell line. These stem-cell like characteristics could potentially add to the increased malignancy and chemoresistance of the blastemal subtype. Along with TCF3, we detected several additional biomarkers that are distinctive for blastemal Wilms tumors after neoadjuvant chemotherapy and that may provide leads for new therapeutic regimens.

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“… 48 , 49 Specific examples of chemotherapeutic agents and increased prohibitin include playtycodin 50 and etoposide. 51 …”

Section: Discussionmentioning

confidence: 99%

Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats

et al. 2018

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To evaluate microbeam radiation therapy (MRT), for brain tumor treatment, the bystander effect in nonirradiated companion animals was investigated. Adult rats were irradiated with 35 or 350 Gy at the European Synchrotron Research Facility using homogenous irradiation (HR) or MRT to the right brain hemisphere. The irradiated rats were housed with nonirradiated rats. After 48 hours, all rats were euthanized and the frontal lobe proteome was analyzed using 2-dimensional electrophoresis and mass spectrometry. Proteome changes were determined by analysis of variance (P < .05). Homogenous irradiation increased serum albumin, heat shock protein 71 (HSP-71), triosephosphate isomerase (TPI), fructose bisphosphate aldolase (FBA), and prohibitin and decreased dihydrolipoyl dehydrogenase (DLD) and pyruvate kinase. Microbeam radiation therapy increased HSP-71, FBA, and prohibitin, and decreased aconitase, dihydropyrimidinase, TPI, tubulin DLD, and pyruvate kinase. Cage mates with HR irradiated rats showed increased HSP-71 and FBA and decreased pyruvate kinase, DLD, and aconitase. Cage mates with MRT irradiated rats showed increased HSP-71, prohibitin, and FBA and decreased aconitase and DLD. Homogenous irradiation proteome changes indicated tumorigenesis, while MRT proteome changes indicated an oxidative stress response. The bystander effect of proteome changes appeared antitumorigenic and inducing radioresistance. This investigation also supports the need for research into prohibitin interaction with HSP-70/71 chaperones and cancer therapy.

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Global proteomic profiling identifies etoposide chemoresistance markers in non-small cell lung carcinoma

Cited by 33 publications

References 33 publications

The effect of rosmarinus officinalis and chemotherapeutic etoposide on glioblastoma (u87 mg) cell culture

The effect of rosmarinus officinalis and chemotherapeutic etoposide on glioblastoma (u87 mg) cell culture

The role of TCF3 as potential master regulator in blastemal Wilms tumors

Homogenous and Microbeam X-Ray Radiation Induces Proteomic Changes in the Brains of Irradiated Rats and in the Brains of Nonirradiated Cage Mate Rats

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