Global trend of antimicrobial resistance in common bacterial pathogens in response to antibiotic consumption

Hou, Jie; Long, Xiang; Wang, Xiaolong; Li, Linyun; Mao, Daqing; Ren, Hongqiang

doi:10.1016/j.jhazmat.2022.130042

Cited by 83 publications

(37 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Desde a descoberta da penicilina em 1928 por Alexander Fleming, os antibióticos vêm sendo utilizados nas mais diversas rotinas médicas. Esse uso constante tem levado ao surgimento de resistência por parte das bactérias, através de um processo de seleção natural, ocasionado pela pressão exercida pelo uso exagerado de antibióticos (HOU et al 2023). A literatura aponta para uma possível era pós-antibióticos, onde os antimicrobianos seriam inúteis para tratar infecções por patógenos multirresistentes (SUGDEN & DAVIES 2016).…”

Section: Resistencia a Antibióticos E A Busca Por Novos Fármacosunclassified

“…De acordo com a Organização Mundial de Saúde (OMS) são estimadas 700.000 mortes anualmente, podendo chegar a um total de 10 milhões em 2050, devido a infecções por microrganismos multirresistentes (HOU et al 2023). Esse cenário se agrava pela não descoberta de novos fármacos, que possam ser utilizados contra microrganismos multirresistentes.…”

Section: Resistencia a Antibióticos E A Busca Por Novos Fármacosunclassified

See 1 more Smart Citation

Tiossemicarbazonas Como Potenciais Agentes Antimicrobianos: Uma Mini Revisão

NASCIMENTO¹,

MARQUES²,

SILVA³

et al. 2022

Ciências Da Saúde: Desafios E Potencialidades Em Pesquisa - Volume 2

View full text Add to dashboard Cite

A resistência microbiana é um problema de saúde pública, que vem crescendo mundialmente, podendo chegar a um total de 10 milhões em 2050, em decorrência de infecções causadas por microrganismos multirresistentes. Neste sentido a busca de novas alternativas no combate a essa resistência microbiana é dos problemas que necessitam de soluções urgente. Nesse contexto as tiossemicarbazonas se apresentam como fragmentos multifuncionais que podem conduzir a novas moléculas potencialmente bioativas como agentes antimicrobianos. Este trabalho apresenta uma mini revisão da literatura sobre a aplicação de moléculas tiossemicarbazonas como antimicrobianos.

show abstract

Section: Resistencia a Antibióticos E A Busca Por Novos Fármacosunclassified

Tiossemicarbazonas Como Potenciais Agentes Antimicrobianos: Uma Mini Revisão

NASCIMENTO¹,

MARQUES²,

SILVA³

et al. 2022

Ciências Da Saúde: Desafios E Potencialidades Em Pesquisa - Volume 2

View full text Add to dashboard Cite

show abstract

“…Antibiotic resistance is a pressing public health issue, and global efforts are required to contain it. In particular, controlling antibiotics in environmental matrices is essential as antibiotic residues entering natural ecosystems due to human activities, such as antibiotic manufacturing production and human and nonhuman antibiotic use, can facilitate rapid resistance, accelerate expansion of the environmental resistome, and increase the probability of recruitment of resistance genes into clinically relevant pathogens. − …”

Section: Introductionmentioning

confidence: 99%

Deglycosylation Inactivation Initiated by a Novel Periplasmic Dehydrogenase Complex Provides a Novel Strategy for Eliminating the Recalcitrant Antibiotic Kanamycin

Chen

Liu

Chen

et al. 2023

Environ. Sci. Technol.

View full text Add to dashboard Cite

Biodegradation using enzyme-based systems is a promising approach to minimize antibiotic loads in the environment. Aminoglycosides are refractory antibiotics that are generally considered non-biodegradable. Here, we provide evidence that kanamycin, a common aminoglycoside antibiotic, can be degraded by an environmental bacterium through deglycosylation of its 4′-amino sugar. The unprecedented deglycosylation inactivation of kanamycin is initiated by a novel periplasmic dehydrogenase complex, which we designated AquKGD, composed of a flavin adenine dinucleotidedependent dehydrogenase (AquKGDα) and a small subunit (AquKGDγ) containing a twin-arginine signal sequence. We demonstrate that the formation of the AquKGDα−AquKGDγ complex is required for both the degradation activity of AquKGD and its translocation into the periplasm. Native AquKGD was successfully expressed in the periplasmic space of Escherichia coli, and physicochemical analysis indicated that AquKGD is a stable enzyme. AquKGD showed excellent degradation performance, and complete elimination of kanamycin from actual kanamycin manufacturing waste was achieved with immobilized AquKGD. Ecotoxicity and cytotoxicity tests suggest that AquKGD-mediated degradation produces less harmful degradation products. Thus, we propose a novel enzymatic antibiotic inactivation strategy for effective and safe treatment of recalcitrant kanamycin residues.

show abstract

“…There are many kinds of antibiotics, and they are used in large quantities. Due to the epidemic situation, the use of antibiotics is growing [ 3 , 4 ]. According to statistics, the global consumption of antibiotics in 2018 was 4.02 billion tons, and the use of antibiotics increased by 46% from 2000 to 2018 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Enhanced Photocatalytic Performances of Composites Consisting of Silver Phosphate and N-Doped Carbon Nanomesh for Oxytetracycline Degradation

Tong

Liu

Lin

et al. 2022

IJERPH

View full text Add to dashboard Cite

Photocatalytic technology based on silver phosphate (Ag3PO4) has excellent potential in removing antibiotic pollutants, but the low separation rate of photogenerated hole-electron pairs restricts the application of the photocatalyst. In this study, it was found that the combination of nitrogen-doped carbon (NDC) with carbon defects and Ag3PO4 can significantly enhance the photocatalytic ability of Ag3PO4. After it was exposed to visible light for 5 min, the photocatalytic degradation efficiency of oxytetracycline (OTC) by the composite photocatalyst Ag3PO4@NDC could reach 100%. In addition, the structure of NDC, Ag3PO4, and Ag3PO4@NDC was systematically characterized by SEM, TEM, XRD, Raman, and EPR. The XPS results revealed intense interface interaction between Ag3PO4 and NDC, and electrons would transfer from Ag3PO4 to the NDC surface. A possible mechanism for enhancing the photocatalytic reaction of the Ag3PO4@NDC composite catalyst was proposed. This study provides a highly efficient visible light catalytic material, which can be a valuable reference for designing and developing a new highly efficient visible light catalyst.

show abstract

Global trend of antimicrobial resistance in common bacterial pathogens in response to antibiotic consumption

Cited by 83 publications

References 73 publications

Tiossemicarbazonas Como Potenciais Agentes Antimicrobianos: Uma Mini Revisão

Tiossemicarbazonas Como Potenciais Agentes Antimicrobianos: Uma Mini Revisão

Deglycosylation Inactivation Initiated by a Novel Periplasmic Dehydrogenase Complex Provides a Novel Strategy for Eliminating the Recalcitrant Antibiotic Kanamycin

Highly Enhanced Photocatalytic Performances of Composites Consisting of Silver Phosphate and N-Doped Carbon Nanomesh for Oxytetracycline Degradation

Contact Info

Product

Resources

About