Global tuberculosis research and its future prospects

Garrido-Cárdenas, José Antonio; Lamo-Sevilla, C. de; Cabezas-Fernández, M.T.; Manzano‐Agugliaro, Francisco; Martínez-Lirola, Miguel

doi:10.1016/j.tube.2020.101917

Cited by 43 publications

(23 citation statements)

References 16 publications

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“…It is made up of very different countries like some in Africa: Cameroon and Kenya; some of Europe as Denmark, and some from Asia like Nepal. In this sense, most of the research linked to African countries in general and to Cameroon particularly is linked to the most frequent parasitic diseases [79], such as African trypanosomiasis [80], diarrhea [81] or tuberculosis [82]. Finally, the China cluster is made up of nearby areas of influence such as Taiwan, Singapore, Hong Kong, Macau, or Taiwan.…”

Section: Collaboration Network Of Countriesmentioning

confidence: 99%

Worldwide Research Trends on Medicinal Plants

Alcayde

Garrido-Cárdenas

Manzano‐Agugliaro

2020

IJERPH

310

115

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The use of medicinal plants has been done since ancient times and may even be considered the origin of modern medicine. Compounds of plant origin have been and still are an important source of compounds for drugs. In this study a bibliometric study of all the works indexed in the Scopus database until 2019 has been carried out, analyzing more than 100,000 publications. On the one hand, the main countries, institutions and authors researching this topic have been identified, as well as their evolution over time. On the other hand, the links between the authors, the countries and the topics under research have been analyzed through the detection of communities. The last two periods, from 2009 to 2014 and from 2015 to 2019, have been examined in terms of research topics. It has been observed that the areas of study or clusters have been reduced, those of the last period being those engaged in unclassified drug, traditional medicine, cancer, in vivo study—antidiabetic activity, and animals—anti-inflammatory activity. In summary, it has been observed that the trend in global research is focused more on the search for new medicines or active compounds rather than on the cultivation or domestication of plant species with this demonstrated potential.

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Section: Collaboration Network Of Countriesmentioning

confidence: 99%

Worldwide Research Trends on Medicinal Plants

Alcayde

Garrido-Cárdenas

Manzano‐Agugliaro

2020

IJERPH

310

115

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“…Figure 3 shows a map of Spain's international collaboration. There is scarce, or almost no, collaboration with African countries, despite the fact that, as will be seen later, the pharmaceutical industry and the area of medicine are very prominent in the domain of patents, and there are very widespread diseases in these areas, such as malaria [39], AIDS, or tuberculosis [40]. The top 20 Spanish institutions that have contributed mostly with their publications to international patents are shown in Figure 4.…”

Section: Countries Affiliations and Collaborationsmentioning

confidence: 99%

The Contribution of Spanish Science to Patents: Medicine as Case of Study

Cascajares

Alcayde

Garrido-Cárdenas

et al. 2020

IJERPH

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Investments in research and development (R&D) and innovation are expensive, and one wishes to be assured that there is positive feedback and to receive guidance on how to direct investments in the future. The social or economic benefits of investments in R&D are of particular interest to policymakers. In this regard, public expense in research, especially through universities, is sometimes being questioned. This paper establishes a measure of how research in Spain, and specifically in its universities, is involved. In this study, we have analyzed all the literature cited in the period 1998–2018 produced by Spanish institutions and which has been cited in at least one international patent, obtaining more than 40,000 publications from more than 160,000 different authors. The data have been surprisingly positive, showing that practically all public universities contribute to this subject and that there is a great deal of international collaboration, both in terms of the number of countries with which they collaborate and the prestige of the institutions involved. Regarding the specific scientific fields in which this collaboration is most relevant, biochemistry, genetics and molecular biology, and medicine together account for almost 40% of the total works. The topics most used by these publications were those of diseases or medical problems such as: Neoplams, Carcinoma, Alzheimer Disease, or human immunodeficiency virus (HIV-1). Oncology was according to the All Science Journal Classification (ASJC) the leading and central issue. Therefore, although the result of basic research is difficult to quantify, when it is observed that there is a return in fields such as medicine or global health, it can be said that it is well employed. In terms of journals from a purely bibliometric point of view, it has been observed that some journals do not have a great impact or relative position within their categories, but they do have a great relevance in this area of patent support. Therefore, it would be worthwhile to set up a rank for scientific journals based on the citations of patents, so the percentage of articles cited in patents with Field-Weighted Citation Impact (FWCI) >1, and as an indicator of scientific transfer from universities or research centres, the transference index in patents (TIP) is also proposed.

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“…Tuberculosis (TB) is an infectious disease that is a primary cause of ill health. It is one of the top 10 causes of death in the world, in addition to being the number 1 single infectious disease killer (ranking above HIV/AIDS) [1,2]. Tuberculosis (TB) is caused by the pathogen of Mycobacterium tuberculosis (Mtb) and transmitted through inhalation of aerosolized droplets containing bacilli from an infected individual when coughing or sneezing.…”

Section: Introductionmentioning

confidence: 99%

A synergistic bactericidal effect of low-frequency and low-intensity ultrasound combined with levofloxacin-loaded PLGA nanoparticles on M. smegmatis in macrophages

Xie

Hou

et al. 2020

J Nanobiotechnol

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Purpose: Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), which often parasites in macrophages. This study is performed to investigate the bactericidal effect and underlying mechanisms of low-frequency and low-intensity ultrasound (LFLIU) combined with levofloxacin-loaded PLGA nanoparticles (LEV-NPs) on M. smegmatis (a surrogate of Mtb) in macrophages. Methods and results: The LEV-NPs were prepared using a double emulsification method. The average diameter, zeta potential, polydispersity index, morphology, and drug release efficiency in vitro of the LEV-NPs were investigated. M. smegmatis in macrophages was treated using the LEV-NPs combined with 42 kHz ultrasound irradiation at an intensity of 0.13 W/cm 2 for 10 min. The results showed that ultrasound significantly promoted the phagocytosis of nanoparticles by macrophages (P < 0.05). In addition, further ultrasound combined with the LEV-NPs promoted the production of reactive oxygen species (ROS) in macrophage, and the apoptosis rate of the macrophages was significantly higher than that of the control (P < 0.05). The transmission electronic microscope showed that the cell wall of M. smegmatis was ruptured, the cell structure was incomplete, and the bacteria received severe damage in the ultrasound combined with the LEV-NPs group. Activity assays showed that ultrasound combined with the LEV-NPs exhibited a tenfold higher antibacterial activity against M. smegmatis residing inside macrophages compared with the free drug. Conclusion: These data demonstrated that ultrasound combined with LEV-NPs has great potential as a therapeutic agent for TB.

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Global tuberculosis research and its future prospects

Cited by 43 publications

References 16 publications

Worldwide Research Trends on Medicinal Plants

Worldwide Research Trends on Medicinal Plants

The Contribution of Spanish Science to Patents: Medicine as Case of Study

A synergistic bactericidal effect of low-frequency and low-intensity ultrasound combined with levofloxacin-loaded PLGA nanoparticles on M. smegmatis in macrophages

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