Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis

Hagenau, T.; Vest, Ryan; Gissel, Tina; Poulsen, C. S.; Erlandsen, Mogens; Mosekilde, Leif; Vestergaard, Peter

doi:10.1007/s00198-008-0626-y

Cited by 388 publications

(289 citation statements)

References 29 publications

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“…In accordance with our study, the other studies announced that there was no difference vitamin D levels and PDW among groups in terms of sex (16,22). On the contrary, a study reported that female had slightly higher vitamin D levels than in men (23). In addition, we did not observe a seasonal effect on vitamin D levels.…”

Section: Discussionsupporting

confidence: 91%

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Coşkun¹,

Şahin²

2018

Haseki

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Aim:In this study, we aim to investigate whether any the correlation exists between 25-hidroxy vitamin D (vitamin D) and platelet indices in childhood. Methods:We planned a retrospective study. Firstly, we scanned vitamin D and hemogram tests of children, who consulted to pediatric clinic with any simple complaint from January 2014 to December 2016. We finally included 346 children (168 female and 178 male) aged 0-18 years in order to evaluate the correlation between vitamin D, and platelet indices.Results: Significant differences were not observed between the average ages of the study groups (p=0.856) as well as sex (p=0.907). We did not determine any significant difference among seasons in terms of vitamin D level (p=0.512). Finally, we did not also found any correlation between vitamin D level and platelet indices in all groups (p>0.05). Conclusion:Vitamin D level was not related to platelet indices in healthy children. On the other hand, we consider that there is a need further studies to validate our findings. Sonuç: Sağlıklı çocuklarda vitamin D düzeyi trombosit indeksleri ile ilişkili değildi. Bununla birlikte, bulgularımızı doğrulayacak daha ileri çalışmalara ihtiyaç olduğu düşüncesindeyiz.

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Section: Discussionsupporting

confidence: 91%

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Coşkun¹,

Şahin²

2018

Haseki

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“…In these countries (for a review, see Pierrot-Deseilligny and Souberbielle [PierrotDeseilligny and Souberbielle, 2010]), 25-OH-D serum levels in 'normal' adults are between 40 and 70 nmol/liter on average, with generally only slight differences depending upon the season and consequently, at least for a large part of the year, 75% of people are in a state of insufficiency with a 25-OH-D serum level cut-off of 75 nmol/liter and still almost half of the population is in a state of insufficiency if one considers that the cutoff should be 50 nmol/liter. In tropical or subtropical countries, vitamin D serum levels are generally higher, at least for people not systematically avoiding sun exposure, and a correlation exists between latitude and vitamin D serum levels in white people at the world scale [Hagenau et al 2009]. Such a correlation has also been observed in France, a relatively small country [Chapuy et al 1996].…”

Section: Vitamin D Requirements and Insufficiencymentioning

confidence: 99%

Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis

Pierrot‐Deseilligny

Souberbielle

2013

Ther Adv Neurol Disord

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Abstract:The contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis (MS) is reviewed. Among the multiple recently discovered actions of vitamin D, an immunomodulatory role has been documented in experimental autoimmune encephalomyelitis and in humans. This action in the peripheral immune system is currently the main known mechanism through which vitamin D might influence MS, but other types of actions could be involved within the central nervous system. Furthermore, vitamin D insufficiency is widespread in temperate countries and in patients with MS at the earliest stages of the disease, suggesting that the deleterious effects related to vitamin D insufficiency may be exerted in these patients. In fact, many genetic and environmental risk factors appear to interact and contribute to MS. In genetics, several human leukocyte antigen (HLA) alleles (more particularly HLA-DRB1*1501) could favour the disease whereas some others could be protective. Some of the genes involved in vitamin D metabolism (e.g. CYP27B1) also play a significant role. Furthermore, three environmental risk factors have been identified: past Epstein-Barr virus infection, vitamin D insufficiency and cigarette smoking. Interactions between genetic and environmental risk or protective factors may occur during the mother's pregnancy and could continue during childhood and adolescence and until the disease is triggered in adulthood, therefore possibly modulating the MS risk throughout the first decades of life. Furthermore, some clinical findings already strongly suggest that vitamin D status influences the relapse rate and radiological lesions in patients with MS, although the results of adequately powered randomized clinical trials using vitamin D supplementation have not yet been reported. While awaiting these incontrovertible results, which might be long in coming, patients with MS who are currently in vitamin D insufficiency should be supplemented, at least for their general health status, using moderate doses of the vitamin.

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“…Serum 25(OH)D levels I adopted a value of 54 nmol/l for all regions of the world for use in this study on the basis of a meta-analysis of crosssectional studies on global serum 25(OH)D status (Hagenau et al, 2009). The minimal variation with latitude found in that study is counterintuitive, but variations in skin pigmentation, time spent out of doors and clothing and oral intake of vitamin D may explain it.…”

Section: Multiple Sclerosismentioning

confidence: 99%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

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Background/Objectives: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. Subjects/Methods: This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. Results: The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Conclusions: Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.

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Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis

Abstract: There was no overall influence of latitude on 25(OH)D. However, in separate analyses 25(OH)D decreased with latitude in Caucasians but not in non-Caucasians. A widespread global vitamin D insufficiency was present compared with proposed threshold levels.

Cited by 388 publications

References 29 publications

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Correlation Between Vitamin D Level and Platelet Indices in Children Aged 0-18 Years

Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis

An estimate of the global reduction in mortality rates through doubling vitamin D levels

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