Glomerular filtration rate equations: a comprehensive review

Musso, Carlos G.; Álvarez-Gregori, Joaquín; Jáuregui, José Ricardo; Macías-Núñez, Juan F.

doi:10.1007/s11255-016-1276-1

Cited by 46 publications

(42 citation statements)

References 16 publications

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“…A global assessment of renal function is often ascertained by the glomerular filtration rate (GFR) [14]. GFR is calculated based on serum creatinine, age, body weight, and gender, and is used clinically to evaluate the level of kidney function and disease progression [15]. Chronic kidney disease can be separated into five stages based on GFR.…”

Section: Introductionmentioning

confidence: 99%

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Hartogh

Tsiani

2019

Nutrients

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Different diseases and disorders that affect the kidneys include, but are not limited to, glomerulonephritis, diabetic nephropathy, polycystic kidney disease, kidney stones, renal fibrosis, sepsis, and renal cell carcinoma. Kidney disease tends to develop over many years, making it difficult to identify until much later when kidney function is severely impaired and undergoing kidney failure. Although conservative care, symptom management, medication, dialysis, transplantation, and aggressive renal cancer therapy are some of the current strategies/approaches to kidney disease treatment, new preventative targeted therapies are needed. Epidemiological studies have suggested that a diet rich in fruits and vegetables is associated with health benefits including protection against kidney disease and renal cancer. Resveratrol, a polyphenol found in grapes and berries, has been reported to have antioxidant, anti-inflammatory, antidiabetic, hepatoprotective, neuroprotective, and anti-cancer properties. The current review summarizes the existing in vitro and in vivo animal and human studies examining the nephroprotective effects of resveratrol.

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Section: Introductionmentioning

confidence: 99%

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Hartogh

Tsiani

2019

Nutrients

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“…Stage 3 is a 3-fold rise in sCr and more than 24 hours with decreased urine output. The estimated glomerular filtration rate (eGFR) was determined using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation [13]. Chronic kidney disease was defined by an eGFR ≤ 60 mL/min/1.73 m 2 based on past medical records.…”

Section: Methodsmentioning

confidence: 99%

NGAL in trans-catheter aortic valve implantation on and off RenalGuard

2021

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Introduction: Acute kidney injury (AKI) is a well-known complication post invasive cardiac procedures. RenalGuard system has been shown to reduce the risk of AKI in high-risk patients by evacuating iodine-based contrast material rapidly. Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein stored in granules of mature neutrophils and is released to the blood stream due to acute tubular damage. This report examined the biomarker as a sub study of the randomized sham control study REDUCE-AKI in the setting of Trans-Aortic Valve Implantation (TAVI). Methods: Venous blood was drawn from 27 patients. Blood was drawn at designated time intervals: before the procedure, after 12 hours and after 24 hours. Patients were randomly allocated to active versus sham RenalGuard activity. Results: There was no difference between baseline and 24 hours levels in NGAL values (ng/mL) in the sham group (median 70.3 IQ 21.5, 176.6) versus the active group (median 46.9, IQR 1.3, 127.7) (P = 0.259). There was also no association between NGAL and clinical complications. Conclusion: Forced diuresis with matched hydration does not prevent AKI in patients undergoing TAVI and measuring NGAL correlates with these findings.

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“…Subjects were diagnosed using the American Diabetic Association Criteria [18]. DKD was defined as the presence of micro—or macro-albuminuria and/or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m 2 [19]. Of this group, eGFR values were obtained for 1325 of 1640 T2D subjects, and 367 of these 1325 T2D subjects were diagnosed with DKD.…”

Section: Methodsmentioning

confidence: 99%

Cholesteryl Ester Transfer Protein Genetic Variants Associated with Risk for Type 2 Diabetes and Diabetic Kidney Disease in Taiwanese Population

Huang

Chen

Liu

et al. 2019

Genes

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Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism. Low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of type 2 diabetes (T2D). This study investigated CETP gene variants to assess the risk of T2D and specific complications of diabetic kidney disease (DKD) and diabetic retinopathy. Towards this, a total of 3023 Taiwanese individuals (1383 without T2D, 1640 with T2D) were enrolled in this study. T2D mice (+Leprdb/+Leprdb, db/db) were used to determine CETP expression in tissues. The A-alleles of rs3764261, rs4783961, and rs1800775 variants were found to be independently associated with 2.86, 1.71, and 0.91 mg/dL increase in HDL-C per allele, respectively. In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71–0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64–0.96). CETP expression was significantly decreased in the T2D mice kidney compared to that in the control mice (T2D mice, 0.16 ± 0.01 vs. control mice, 0.21 ± 0.02; p = 0.02). These collective findings indicate that CETP variants in the promoter region may affect HDL-C levels. Taiwanese individuals possessing an allele associated with higher HDL-C levels had a lower risk of T2D and DKD.

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Glomerular filtration rate equations: a comprehensive review

Cited by 46 publications

References 16 publications

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

Health Benefits of Resveratrol in Kidney Disease: Evidence from In Vitro and In Vivo Studies

NGAL in trans-catheter aortic valve implantation on and off RenalGuard

Cholesteryl Ester Transfer Protein Genetic Variants Associated with Risk for Type 2 Diabetes and Diabetic Kidney Disease in Taiwanese Population

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