Glomerular-Specific Imprinting of the Mouse Gsα Gene: How Does This Relate to Hormone Resistance in Albright Hereditary Osteodystrophy?

Williamson, Christine M.; Schofield, Julian; Dutton, Elizabeth R.; Seymour, Adele; Beechey, C.V.; Edwards, Yvonne H.; Peters, Josephine

doi:10.1006/geno.1996.0463

Cited by 56 publications

(37 citation statements)

References 3 publications

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“…A List of Known Imprinted Genes and a Search for Antisense Transcripts of Known Imprinted Genes Symbols used as known imprinted gene references are as follows; Ata3 (Mizuno et al 2002), Copg2 (Lee et al 2000), Dcn (Mizuno et al 2002), Dlk (Takada et al 2000), Frat3 (Chai J-H et al 2001), Gabra5 (Knoll et al 1993), Gabrb3 (Wagstaff et al 1991), Gabrg3 (Greger et al 1995), Gnas (Williamson et al 1996), Gnasxl (Peters et al 1999), H19 (Leighton et al 1995), Htr2a (Kato et al 1998), Igf2 (De Chiara et al 1991, Igf2as (Moore et al 1997), Igf2r (Barlow et al 1991), Impact (Hagiwara et al 1997), Ins1 (Giddings et al 1994), Ins2 (Leighton et al 1995), Ipl/Tssc3 (Qian et al 1997), Ipw (Wevrick and Francke 1997), Kvlqt1 (Gould andPfeifer 1998), Kvlqt1-as (Smilinich et al 1999), Magel2 (Boccaccio et al 1999), Mas1 (Villar and Pedersen 1994), Mash2 (Guillemot et al 1995), Meg1/ Grb10 (Miyoshi et al 1998), Meg3/Gtl2 (Miyoshi et al 2000), Mit1/lb9 (Lee et al 2000), Mkrn3/ Zfp127 (Jong et al 1999a), Msuit (Onyango et al 2000), Nap1l4 (Paulsen et al 1998), Ndn (MacDonald and Wevrick 1997), Nespas (Wroe et al 2000), Nnat (Kagitani et al 1997), Obph1 , p57KIP2/Cdkn1c (Hatada and Mukai 1995), p73 (Kaghad et al 1997), Peg1/Mest (Kaneko-Ishino et al 1995), Peg3/Pw1 …”

Section: A List Of Known Sense Transcripts With Antisense Transcriptsmentioning

confidence: 99%

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

Kiyosawa¹,

Yamanaka²,

Osato³

et al. 2003

Genome Res.

235

199

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We have used the FANTOM2 mouse cDNA set (60,770 clones), public mRNA data, and mouse genome sequence data to identify 2481 pairs of sense-antisense transcripts and 899 further pairs of nonantisense bidirectional transcription based upon genomic mapping. The analysis greatly expands the number of known examples of sense-antisense transcript and nonantisense bidirectional transcription pairs in mammals. The FANTOM2 cDNA set appears to contain substantially large numbers of noncoding transcripts suitable for antisense transcript analysis. The average proportion of loci encoding sense-antisense transcript and nonantisense bidirectional transcription pairs on autosomes was 15.1 and 5.4%, respectively. Those on the X chromosome were 6.3 and 4.2%, respectively. Sense-antisense transcript pairs, rather than nonantisense bidirectional transcription pairs, may be less prevalent on the X chromosome, possibly due to X chromosome inactivation. Sense and antisense transcripts tended to be isolated from the same libraries, where nonantisense bidirectional transcription pairs were not apparently coregulated. The existence of large numbers of natural antisense transcripts implies that the regulation of gene expression by antisense transcripts is more common that previously recognized. The viewer showing mapping patterns of sense-antisense transcript pairs and nonantisense bidirectional transcription pairs on the genome and other related statistical data is available on our Web site.

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Section: A List Of Known Sense Transcripts With Antisense Transcriptsmentioning

confidence: 99%

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

Kiyosawa¹,

Yamanaka²,

Osato³

et al. 2003

Genome Res.

235

199

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“…The reciprocal translocation T(2;8)26H was used as described previously (Williamson et al 1996). MatDp(dist2), PatDp(dist2), and wild-type embryos were identified at 15.5 dpc by typing for the marker D2Mit226 (Williamson et al 1995).…”

Section: Distal Chr 2-duplication/deficient Micementioning

confidence: 99%

“…In contrast, mice with two paternal copies but no maternal copies [PatDp(dist2)] are hyperactive, edematous, and usually die within a few days of birth. In recent years, the Gnas complex locus has been shown to lie within the region (Williamson et al 1996) and to be imprinted Peters et al 1999). Some features of the PatDp(dist2) and MatDp(dist2) mice are recapitulated in mice with maternal and paternal inheritance, respectively, of a targeted deletion of Gnas exon 2 (Yu et al 1998), and also in Oed mice (Cattanach et al 2000), which have a missense mutation in Gnas exon 6 .…”

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confidence: 99%

A Comprehensive Transcript Map of the Mouse Gnas Imprinted Complex

Holmes

Williamson²,

Peters³

et al. 2003

Genome Res.

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The recent publication of the FANTOM mouse transcriptome has provided a unique opportunity to study the diversity of transcripts arising from a single gene locus. We have focused on the Gnas complex, as imprinting loci themselves provide unique insights into transcriptional regulation. Thirteen full-length cDNAs from the FANTOM2 set were mapped to the Gnas locus. These represented one previously described transcript and 12 putative new transcripts. Of these, eight were found to be differentially expressed from either the maternal or paternal allele. Two clones extended Nespas in the 3Ј direction, providing evidence of antisense transcription spanning a 30-kb genomic region from a single allele. The transcripts were summarized into six transcriptional units, Nespas, Nesp, Gnasxl, F7, exon 1A, and Gnas. The resolution of the Gnas transcript map by the FANTOM2 clones revealed a pattern of alternate splicing. In addition to the transcripts described previously as splicing onto exon 2 of Gnas, each new sense transcript had an alternate short 3ЈUTR independent of Gnas. Both spliced and unspliced variants of the new imprinted sense transcripts were found. Whereas the functional significance of these alternate transcripts is not known, the availability of the FANTOM clones has provided remarkable insights into the repertoire of transcripts in the Gnas complex locus.

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“…Ga s mRNA is widely expressed throughout the renal cells in the nephron and blood vessels. Ga s mRNA was detected in isolated rat nephron segments, including medullary thick ascending limbs and collecting ducts using reverse-transcription polymerase chain reaction (RT-PCR) (Senkfor et al, 1993), and mouse glomeruli and proximal tubules using in situ hybridization (Williamson et al, 1996;Yu et al, 1998). At the protein level, Ga s was detected in the glomeruli (Brunskill et al, 1991;Yanagisawa et al, 1993Yanagisawa et al, , 1994Nitta et al, 1994), proximal convoluted tubules (Brunskill et al, 1991;Stow et al, 1991), thick ascending limbs of Henle (Stow et al, 1991), collecting ducts (Stow et al, 1991), and preglomerular vessels from rats (Ruan et al, 1999).…”

Section: G Protein Subunit Localization In the Kidneymentioning

confidence: 99%

Activators of G Protein Signaling in the Kidney

Park

2015

J Pharmacol Exp Ther

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Heterotrimeric G proteins play a crucial role in regulating signal processing to maintain normal cellular homeostasis, and subtle perturbations in its activity can potentially lead to the pathogenesis of renal disorders or diseases. Cell-surface receptors and accessory proteins, which normally modify and organize the coupling of individual G protein subunits, contribute to the regulation of heterotrimeric G protein activity and their convergence and/or divergence of downstream signaling initiated by effector systems. Activators of G protein signaling (AGS) are a family of accessory proteins that intervene at multiple distinct points during the activation-inactivation cycle of G proteins, even in the absence of receptor stimulation. Perturbations in the expression of individual AGS proteins have been reported to modulate signal transduction pathways in a wide array of diseases and disorders within the brain, heart, immune system, and more recently, the kidney. This review will provide an overview of the expression profile, localization, and putative biologic role of the AGS family in the context of normal and diseased states of the kidney.

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Glomerular-Specific Imprinting of the Mouse Gsα Gene: How Does This Relate to Hormone Resistance in Albright Hereditary Osteodystrophy?

Cited by 56 publications

References 3 publications

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

A Comprehensive Transcript Map of the Mouse Gnas Imprinted Complex

Activators of G Protein Signaling in the Kidney

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