Glomerulitis During Acute Cellular Rejection May Be a Surrogate Marker of Vasculitis in Renal Allografts—Better Index for Diagnosis of Vasculitis

Desai, H.; Parasuraman, Ravi; Samarpungavan, D.; Rooney, Michelle Nayahamui; Cohn, Steven; Reddy, Gopal; Rocher, Leslie L.; Dumler, Francis; Zhang, P.L.

doi:10.1016/j.transproceed.2011.01.187

Cited by 6 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,4,27,30 CD15þ neutrophils comprised 27.8% of arterial immunocytes within v3 lesions in explanted C4d ptc -positive AMR kidneys. 30 Although CD68þ glomerulitis and peritubular capillaritis constitute indirect evidence of microcirculation AMR, [31][32][33][34] CD3þ/CD68þ arterial VR ratios failed to distinguish C4d ptc . 32 We regard dominant lymphocytic infiltration without C4d, MVI, or DSA as diagnostic of TCM-VR.…”

Section: Discussionmentioning

confidence: 97%

The Clinical and Pathologic Phenotype of Antibody-Mediated Vascular Rejection Diagnosed Using Arterial C4d Immunoperoxidase

Nankivell

Shingde

P’ng

et al. 2022

Kidney International Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

The Clinical and Pathologic Phenotype of Antibody-Mediated Vascular Rejection Diagnosed Using Arterial C4d Immunoperoxidase

Nankivell

Shingde

P’ng

et al. 2022

Kidney International Reports

View full text Add to dashboard Cite

“…However, in our experience, these biopsies often contain abundant T-cell infiltrates and readily demonstrable tubulitis, yet the possibility that these can primarily reflect T-cell mediated rejection (TCMR) is not often considered [7]. T-cell infiltrates have been specifically described in the setting of transplant mediated glomerulitis [8][9][10][11]. Therefore, the possibility that T-cells can recognize endothelial antigens and directly cause MVI deserves more frequent consideration.…”

Section: Introductionmentioning

confidence: 99%

T‐cell Mediated Rejection Associated Microvascular Inflammation in the Allograft Kidney: RNAseq Analysis Using the Banff Human Organ Transplant Gene Panel

Barwad,

Huang,

Randhawa

2024

Clinical Transplantation

View full text Add to dashboard Cite

BackgroundMicrovascular inflammation (MVI) can occur in biopsies showing T‐cell mediated rejection (TCMR), but it is not well established that T‐cells can directly mediate microvascular injury (TCMR‐MVI).MethodsThis was a cross sectional RNAseq based Banff Human Organ Transplant (BHOT) gene expression (GE) analysis. The objective of this study was to probe the molecular signature of TCMR‐MVI in comparison with C4d+, DSA+ antibody mediated rejection (ABMR), stable renal function (STA), and TCMR without MVI. Transcriptome analysis utilized CLC genomic workbench and R‐studio software.ResultsNo gene set was specific for any diagnostic category, and all were expressed at low levels in STA biopsies. BHOT gene set scores could differentiate ABMR from TCMR and TCMR‐MVI, but not TCMR from TCMR‐MVI. TCMR‐MVI underexpressed several genes associated with ABMR including DSATs, ENDAT, immunoglobulin genes, ADAMDEC1, PECAM1 and NK cell transcripts (MYBL1, GNLY), but overexpressed C3, NKBBIZ, and LTF. On the other hand, there was no significant difference in the expression of these genes in TCMR‐MVI versus TCMR. This indicates that the GE profile of TCMR MVI aligns more closely with TCMR than ABMR. The limitations of classifying biopsies using the binary ABMR‐TCMR algorithm, and the occurrence of common pathogenesis mechanisms amongst different rejection phenotype was highlighted by the frequent presence of molecular mixed rejection.ConclusionsT‐cell mediated mechanisms play a significant role in the pathogenesis of MVI. GE was broadly different between rejection phenotypes, but molecular scores varied substantially between biopsies with the same Banff grade. It was not always possible to achieve precise molecular score‐based diagnostic categorization of individual patients.

show abstract

Glomerulitis in T cell-mediated renal allograft rejection and antibody-mediated rejection histology in the absence of donor-specific antibodies heralds a similar clinico-morphologic pattern of injury to an antibody-mediated rejection: A systematic review

Bajaj,

Kashif,

Singh

et al. 2024

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Glomerulitis During Acute Cellular Rejection May Be a Surrogate Marker of Vasculitis in Renal Allografts—Better Index for Diagnosis of Vasculitis

Cited by 6 publications

References 8 publications

The Clinical and Pathologic Phenotype of Antibody-Mediated Vascular Rejection Diagnosed Using Arterial C4d Immunoperoxidase

The Clinical and Pathologic Phenotype of Antibody-Mediated Vascular Rejection Diagnosed Using Arterial C4d Immunoperoxidase

T‐cell Mediated Rejection Associated Microvascular Inflammation in the Allograft Kidney: RNAseq Analysis Using the Banff Human Organ Transplant Gene Panel

Glomerulitis in T cell-mediated renal allograft rejection and antibody-mediated rejection histology in the absence of donor-specific antibodies heralds a similar clinico-morphologic pattern of injury to an antibody-mediated rejection: A systematic review

Contact Info

Product

Resources

About