Glomus tumor of the duodenum: a rare case report

Abstract

Background Glomus tumors (GTs) are mesenchymal neoplastic lesions arising from the glomus bodies and generally occur in the fingers and toes. Gastrointestinal GTs are rare, and most of them originate from the stomach; however, GT arising from the duodenum is exceedingly rare. Case presentation A 68-year-old man was admitted due to abdominal pain. Endoscopy showed a round, smooth, elevated mass in the second portion of the duodenum with central ulceration. Abdominal contrast computed tomography showed a hypervascular tumor measuring 26 mm in diameter in the second portion of the duodenum, and pancreatic invasion was suspected. Endoscopic ultrasonography of the lesion confirmed a hypoechoic mass arising from the fourth layer of the duodenal wall. A biopsy was performed for central ulceration, and immunochemical studies showed positive results for smooth muscle actin (SMA) and negative results for S100, C-Kit, and CD34. Leiomyoma or gastrointestinal stromal tumor was suspected and pancreatoduodenectomy was performed. The specimen exhibited a vascular-rich tumor, 24 × 24 × 19 mm in size, with deep ulceration in the duodenum. Histological examination showed uniform small round cells with central nuclei and a pale cytoplasm (glomus cell) with perivascular proliferation. Immunochemical studies showed that the tumor was positive for SMA and collagen type IV, and negative for C-Kit, CD34, desmin, and S100. We diagnosed the tumor as a GT of the duodenum. Conclusion GTs of the duodenum are exceedingly rare, but should be considered in the differential diagnoses of duodenal submucosal lesions.

Glomangioma Supply from Profunda Femoris Artery in Peripheral Artery Disease

“…The differential diagnosis for glomangioma includes vascular malformation, which does not have perivascular glomus cell accumulation [ 21 , 22 ]. Other morphophonological entities included in the differential l diagnosis are myopericytoma, angioleiomyoma, and myofibroma.…”

Gastric glomus tumor diagnosed by fine needle aspiration of the stomach: A report of two cases and review of the literature

“…Glomus tumors commonly present in peripheral soft tissues such as the subungual regions of the fingers and toes 8 and arise from the arterial portion of the glomus body 9 . However, in rare occasions, glomus tumors can arise in the gastrointestinal tract, specifically, in the stomach 8 .…”

“…Glomus tumors commonly present in peripheral soft tissues such as the subungual regions of the fingers and toes 8 and arise from the arterial portion of the glomus body 9 . However, in rare occasions, glomus tumors can arise in the gastrointestinal tract, specifically, in the stomach 8 . Gastric glomus tumors are equally as likely to present in men and women with a median age of 56 years old 5 with a range from 18 to 89 years old 6 .…”

“…Gastric glomus tumors are equally as likely to present in men and women with a median age of 56 years old 5 with a range from 18 to 89 years old 6 . Most patients with glomus tumors are asymptomatic, but can present with clinical symptoms such as abdominal pain, dizziness, gastrointestinal bleeding, dark stool, high blood pressure, and ulcerous syndrome 1,8,10–12 . The average size of gastric glomus tumors has been reported to be between 2.0 and 2.5 cm 13 …”

The clinicopathologic and immunohistochemical features of 60 cutaneous glomus tumor: a retrospective case series study

“…It generally occurs in the fingers, especially the nailbeds. 1 GT is often misdiagnosed, leading to pain and delay in treatment. Allodynia, localized tenderness, and cold hypersensitivity are the key to diagnosing GT.…”